Paul Coen
@coenpm.bsky.social
Dad | Husband | Aging, Diabetes and Exercise Researcher | Liverpool FC | Weekend Warrior
Sharing the result of a collaboration with Kristin Stanford and team @OhioStateDHLRI: The brown fat–derived lipokine 12,13-diHOME combats age-related heart decline by inhibiting CaMKII and reducing ER stress.
doi.org/10.1038/s414...
@AdventHealthMD
doi.org/10.1038/s414...
@AdventHealthMD
12,13-diHOME protects against the age-related decline in cardiovascular function via attenuation of CaMKII - Nature Communications
Cardiovascular function declines with age. In this study, the authors show that the BAT-derived lipokine 12,13-diHOME preserves cardiac function in aged mice by attenuating pathological CaMKII activit...
doi.org
August 2, 2025 at 11:01 PM
Sharing the result of a collaboration with Kristin Stanford and team @OhioStateDHLRI: The brown fat–derived lipokine 12,13-diHOME combats age-related heart decline by inhibiting CaMKII and reducing ER stress.
doi.org/10.1038/s414...
@AdventHealthMD
doi.org/10.1038/s414...
@AdventHealthMD
The Study of Muscle Mobility and Aging (SOMMA) is open for enrollment!!
SOMMA is a prospective, longitudinal cohort study designed to examine the biological properties of skeletal muscle that predict onset of disability or dementia in older adults.
Learn more about SOMMA:
sommaonline.ucsf.edu
SOMMA is a prospective, longitudinal cohort study designed to examine the biological properties of skeletal muscle that predict onset of disability or dementia in older adults.
Learn more about SOMMA:
sommaonline.ucsf.edu
July 22, 2025 at 10:00 PM
The Study of Muscle Mobility and Aging (SOMMA) is open for enrollment!!
SOMMA is a prospective, longitudinal cohort study designed to examine the biological properties of skeletal muscle that predict onset of disability or dementia in older adults.
Learn more about SOMMA:
sommaonline.ucsf.edu
SOMMA is a prospective, longitudinal cohort study designed to examine the biological properties of skeletal muscle that predict onset of disability or dementia in older adults.
Learn more about SOMMA:
sommaonline.ucsf.edu
Delighted to share a recent publication from a long standing collaboration with @siobhanmalany.bsky.social, Maddalena Parafati, and their outstanding team at University of Florida.
www.cell.com/stem-cell-re...
@spacex.extwitter.link
@stemcellreports.bsky.social
@adventhealth.bsky.social
www.cell.com/stem-cell-re...
@spacex.extwitter.link
@stemcellreports.bsky.social
@adventhealth.bsky.social
Microgravity accelerates skeletal muscle degeneration: Functional and transcriptomic insights from an ISS muscle lab-on-chip model
In this article, Parafati, Malany, and colleagues show that microgravity altered contractile
response and slow-twitch protein levels in a lab-on-chip muscle model on the ISS.
Electrical stimulation en...
www.cell.com
July 19, 2025 at 12:53 AM
Delighted to share a recent publication from a long standing collaboration with @siobhanmalany.bsky.social, Maddalena Parafati, and their outstanding team at University of Florida.
www.cell.com/stem-cell-re...
@spacex.extwitter.link
@stemcellreports.bsky.social
@adventhealth.bsky.social
www.cell.com/stem-cell-re...
@spacex.extwitter.link
@stemcellreports.bsky.social
@adventhealth.bsky.social
We are recruiting! We have an open position for a Postdoctoral Fellow with the Aging, Exercise and Bioenergetics group at the Translational Research Institute in Orlando, Florida. If you know of an any trainees who might be interested, please let them know!
jobs.adventhealth.com/orlando-fl/r...
jobs.adventhealth.com/orlando-fl/r...
Jobs | AdventHealth
jobs.adventhealth.com
May 20, 2025 at 11:48 PM
We are recruiting! We have an open position for a Postdoctoral Fellow with the Aging, Exercise and Bioenergetics group at the Translational Research Institute in Orlando, Florida. If you know of an any trainees who might be interested, please let them know!
jobs.adventhealth.com/orlando-fl/r...
jobs.adventhealth.com/orlando-fl/r...
Reposted by Paul Coen
Acute myeloid leukemia mitochondria hydrolyze ATP to support oxidative metabolism and resist chemotherapy
Acute myeloid leukemia mitochondria hydrolyze ATP to support oxidative metabolism and resist chemotherapy
Unlike healthy blood cells, AML cells reverse the ATP synthase reaction to support oxidative metabolism and resist chemotherapy.
www.science.org
April 24, 2025 at 10:35 PM
Acute myeloid leukemia mitochondria hydrolyze ATP to support oxidative metabolism and resist chemotherapy
WTF! Leadership of the National Institute on Aging was apparently “decimated,” with deputy director Amy Kelly and scientific director Luigi Ferrucci— “one of the brightest luminaries in the world in gerontology,” per a source — among those fired.
www.splinter.com/bloodbath-at...
www.splinter.com/bloodbath-at...
'Bloodbath' at NIH and Elsewhere at HHS Begins
Splinter is your home for news and opinions that challenge power in our political and economic system that's becoming more unhinged each and every day.
www.splinter.com
April 1, 2025 at 8:59 PM
WTF! Leadership of the National Institute on Aging was apparently “decimated,” with deputy director Amy Kelly and scientific director Luigi Ferrucci— “one of the brightest luminaries in the world in gerontology,” per a source — among those fired.
www.splinter.com/bloodbath-at...
www.splinter.com/bloodbath-at...
Reposted by Paul Coen
Clinical and humans physiology to the fore. Think about submitting your work to The Journal of Physiology.
doi.org/10.1113/jp28...
doi.org/10.1113/jp28...
Here comes the sun: the central role of human and clinical physiology in the era of multi‐omics and inter‐organ crosstalk
Click on the article title to read more.
doi.org
March 31, 2025 at 9:22 AM
Clinical and humans physiology to the fore. Think about submitting your work to The Journal of Physiology.
doi.org/10.1113/jp28...
doi.org/10.1113/jp28...