Christina McBride
@cmayemcbride.bsky.social
chemical biologist & natural products researcher! 🧬🧫🧪 | haverford college '23 | umich chem bio '28 | NSF Fellow | she/her
Thrilled to share my recent work from the Pereira and Sherman Labs at @umlifesciences.bsky.social, out now in Communications Chemistry! We applied metabolic engineering, semi-synthesis, and biocatalysis to expand access to the antimalarial natural product premarineosin A. I suggest you check it out!
Metabolic engineering and late-stage functionalization expand the chemical space of the antimalarial premarineosin A - Communications Chemistry
Premarineosin A, a potent and selective antimalarial natural product, is a promising yet underexplored scaffold due to its limited availability and synthetic complexity. Here, the authors employ metab...
doi.org
December 6, 2025 at 6:21 PM
Thrilled to share my recent work from the Pereira and Sherman Labs at @umlifesciences.bsky.social, out now in Communications Chemistry! We applied metabolic engineering, semi-synthesis, and biocatalysis to expand access to the antimalarial natural product premarineosin A. I suggest you check it out!
Preprint alert!! 🎉 Ever struggle to activate a carrier protein? Led by Kenneth Hsu (Haverford '25), the Charkoudian Lab unearthed a novel PPTase from Dictyobacter vulcani 🌋 with remarkable promiscuity (in our case, better than Sfp & AcpS)!
Grateful to be an alum of this phenomenal research team 💗
Grateful to be an alum of this phenomenal research team 💗
A Phosphopantetheinyl Transferase from Dictyobacter vulcani sp. W12 Expands the Combinatorial Biosynthetic Toolkit
The value of microbial natural product pathways extends beyond the chemicals they produce, as the enzymes they encode can be harnessed as biocatalysts. Microbial type II polyketide synthases (PKSs) ar...
www.biorxiv.org
March 28, 2025 at 8:45 PM
Preprint alert!! 🎉 Ever struggle to activate a carrier protein? Led by Kenneth Hsu (Haverford '25), the Charkoudian Lab unearthed a novel PPTase from Dictyobacter vulcani 🌋 with remarkable promiscuity (in our case, better than Sfp & AcpS)!
Grateful to be an alum of this phenomenal research team 💗
Grateful to be an alum of this phenomenal research team 💗
New preprint 🥳 the first of my PhD! We applied metabolic engineering🦠, semi-synthesis👩🔬, and biocatalysis🧪 to access & improve the potency of the antimalarial natural product (-)-premarineosin A.
I'm so lucky to work with such a creative, interdisciplinary, and fun team that made this all possible!
I'm so lucky to work with such a creative, interdisciplinary, and fun team that made this all possible!
Advancing (-)-Premarineosin A as a Potent Antimalarial Therapeutic via Metabolic Engineering and Late-Stage Derivatization
Despite modern preventative and curative efforts, malaria has remained a major global health crisis. In 2023 alone, malaria was responsible for an estimated 263 million cases and 597,000 deaths. To co...
www.biorxiv.org
February 6, 2025 at 2:25 PM
New preprint 🥳 the first of my PhD! We applied metabolic engineering🦠, semi-synthesis👩🔬, and biocatalysis🧪 to access & improve the potency of the antimalarial natural product (-)-premarineosin A.
I'm so lucky to work with such a creative, interdisciplinary, and fun team that made this all possible!
I'm so lucky to work with such a creative, interdisciplinary, and fun team that made this all possible!
Reposted by Christina McBride
Are you working on natural products? We’ve just released version 4.0 of the MIBiG data standard and repository! It now includes 3059 biosynthetic gene clusters, thanks to the combined efforts of 288 expert contributors. A thread: (1/8) academic.oup.com/nar/advance-...
MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration
Abstract. Specialized or secondary metabolites are small molecules of biological origin, often showing potent biological activities with applications in ag
academic.oup.com
December 10, 2024 at 8:05 AM
Are you working on natural products? We’ve just released version 4.0 of the MIBiG data standard and repository! It now includes 3059 biosynthetic gene clusters, thanks to the combined efforts of 288 expert contributors. A thread: (1/8) academic.oup.com/nar/advance-...