Sam Brown
@brownlab.bsky.social
Evolutionary microbiologist. Bacterial social life, virulence, drug resistance.
Reposted by Sam Brown
Very happy to see this piece out in @plosbiology.org, on the bacterial immune systems and microbial communities. It was a great team effort with Rafael Custodio, @brockhurstlab.bsky.social , @brownlab.bsky.social, and Edze Westra! 🦠🧫 #phagesky #mevosky
journals.plos.org/plosbiology/...
journals.plos.org/plosbiology/...
Bacterial immune systems as causes and consequences of microbiome structure
Bacterial immune systems have evolved in response to diverse molecular "parasites", yet their ecological roles remain poorly understood. This Essay explores how interactions between mobile genetic ele...
journals.plos.org
November 19, 2025 at 6:35 PM
Very happy to see this piece out in @plosbiology.org, on the bacterial immune systems and microbial communities. It was a great team effort with Rafael Custodio, @brockhurstlab.bsky.social , @brownlab.bsky.social, and Edze Westra! 🦠🧫 #phagesky #mevosky
journals.plos.org/plosbiology/...
journals.plos.org/plosbiology/...
Reposted by Sam Brown
The ecological roles of bacterial #immune systems are poorly understood. Rafael Custodio @ellinoralseth.bsky.social @brockhurstlab.bsky.social @brownlab.bsky.social & Edze Westra explore how mobile genetic elements and bacterial defenses shape #microbiome structure and function 🧪
Bacterial immune systems as causes and consequences of microbiome structure
Bacterial immune systems have evolved in response to diverse molecular "parasites", yet their ecological roles remain poorly understood. This Essay explores how interactions between mobile genetic…
plos.io
November 20, 2025 at 1:55 PM
The ecological roles of bacterial #immune systems are poorly understood. Rafael Custodio @ellinoralseth.bsky.social @brockhurstlab.bsky.social @brownlab.bsky.social & Edze Westra explore how mobile genetic elements and bacterial defenses shape #microbiome structure and function 🧪
Thanks Andrew, @jrchandler.bsky.social and @ajaidandekar.bsky.social for great commentary! I totally agree, so much more to do. One exciting prospect is using regulatory wiring knowledge to improve our abilities to predict bug behaviors 'in the wild'. Our fig 7B is encouraging start, IMO.
Andrew Frando, @jrchandler.bsky.social, and I wrote a primer about excellent work done in Sam Brown's group @brownlab.bsky.social
journals.plos.org/plosbiology/...
journals.plos.org/plosbiology/...
Better together: Reciprocal activation of quorum sensing circuits enhances bacterial communication
Many bacteria use quorum sensing to control gene transcription based on population density. This primer explores a recent study in PLOS Biology which found that in Pseudomonas aeruginosa, two quorum-s...
journals.plos.org
September 17, 2025 at 5:37 PM
Thanks Andrew, @jrchandler.bsky.social and @ajaidandekar.bsky.social for great commentary! I totally agree, so much more to do. One exciting prospect is using regulatory wiring knowledge to improve our abilities to predict bug behaviors 'in the wild'. Our fig 7B is encouraging start, IMO.
Reposted by Sam Brown
Bacterial #QuorumSensing is often assumed to follow a strict hierarchy. @brownlab.bsky.social &co find that #Pseudomonas aeruginosa instead uses a reciprocal, cooperative system that enhances responsiveness to population density & environmental changes @plosbiology.org 🧪 plos.io/3I7DhRG
September 8, 2025 at 7:55 AM
Bacterial #QuorumSensing is often assumed to follow a strict hierarchy. @brownlab.bsky.social &co find that #Pseudomonas aeruginosa instead uses a reciprocal, cooperative system that enhances responsiveness to population density & environmental changes @plosbiology.org 🧪 plos.io/3I7DhRG
Reposted by Sam Brown
Latest Microbial Primer on 'polymicrobial infections' from @jenniferfarrell.bsky.social @brownlab.bsky.social and published by the @microbiologysociety.org. Check out all Primers which are useful introductions to topics and they are good for teaching. www.microbiologyresearch.org/content/micr...
Microbial Primers | Microbiology Society
In the constantly evolving world of microbiology, new research and discoveries can often be overwhelming. ‘Microbial Primers’ is a series of short articles designed to simplify and illuminate intricat...
www.microbiologyresearch.org
June 20, 2025 at 4:00 PM
Latest Microbial Primer on 'polymicrobial infections' from @jenniferfarrell.bsky.social @brownlab.bsky.social and published by the @microbiologysociety.org. Check out all Primers which are useful introductions to topics and they are good for teaching. www.microbiologyresearch.org/content/micr...
Reposted by Sam Brown
I *finally* get to share our work on plasmid competition– super proud to now have this on bioRxiv:
CRISPR-Cas is beneficial in plasmid competition, but limited by competitor toxin-antitoxin activity when horizontally transferred
www.biorxiv.org/content/10.1...
1/6 👇
CRISPR-Cas is beneficial in plasmid competition, but limited by competitor toxin-antitoxin activity when horizontally transferred
www.biorxiv.org/content/10.1...
1/6 👇
May 12, 2025 at 5:11 AM
I *finally* get to share our work on plasmid competition– super proud to now have this on bioRxiv:
CRISPR-Cas is beneficial in plasmid competition, but limited by competitor toxin-antitoxin activity when horizontally transferred
www.biorxiv.org/content/10.1...
1/6 👇
CRISPR-Cas is beneficial in plasmid competition, but limited by competitor toxin-antitoxin activity when horizontally transferred
www.biorxiv.org/content/10.1...
1/6 👇
Hello world! I'm starting out on bluesky with a job posting - we're looking for lab research tech who shares our love of bugs. More info here brownlab.biology.gatech.edu/opportunities/
Opportunities
brownlab.biology.gatech.edu
January 17, 2025 at 6:35 PM
Hello world! I'm starting out on bluesky with a job posting - we're looking for lab research tech who shares our love of bugs. More info here brownlab.biology.gatech.edu/opportunities/