@brianfclarke.bsky.social
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brianfclarke.bsky.social
We're hiring!

Want use deep learning to discover genetic disease mechanisms and therapeutic targets? Like the sound of applying Bayesian deep learning, DNA language models and federated learning to this exciting problem? Then this position in our group is for you!
PhD Student in Deep Learning for Rare Variant Genetics
jobs.dkfz.de
Reposted
manusaraswat.bsky.social
Excited to be at #ASHG2025 in Boston next week. On Thursday, I will be presenting a poster (1007T) on our latest work on Personalised sequence to expression modelling. Looking forward to meeting new folks and reconnecting with old friends and colleagues.
Reposted
steglelab.bsky.social
Don’t miss Manu’s poster on DeepGenoXcan, our new personalized and interpretable sequence-to-expression model, at #ASHG2025!

📅 October 16, 2:30pm-4:30pm
📍 Poster 1007T
manusaraswat.bsky.social
Excited to be at #ASHG2025 in Boston next week. On Thursday, I will be presenting a poster (1007T) on our latest work on Personalised sequence to expression modelling. Looking forward to meeting new folks and reconnecting with old friends and colleagues.
Reposted
steglelab.bsky.social
Do you want to link genomic variants to functional gene expression - cell by cell?
SDR-seq makes it possible; an experimental method connecting coding and non-coding variants to expression in single cells.
Proud to have contributed a custom FASTQ-processing tool to this great collaborative project.
embl.org
EMBL @embl.org · 5d
EMBL scientists have created a more sensitive single-cell sequencing tool for genomic variants and RNA in the same single cell.

Known as SDR-seq, the tool has unprecedented scale, precision, and speed to characterise variants and link them to functions and disease.

www.embl.org/news/science...
New tool offers single-cell study of specific genetic variants | EMBL
Scientists developed a more sensitive single-cell sequencing tool linking genomic variants & RNA in the same cell uncover links to disease.
www.embl.org
brianfclarke.bsky.social
Grateful to have been included in this interesting and sure to be very impactful work!
yun-s-song.bsky.social
We are excited to share GPN-Star, a cost-effective, biologically grounded genomic language modeling framework that achieves state-of-the-art performance across a wide range of variant effect prediction tasks relevant to human genetics.
www.biorxiv.org/content/10.1...
(1/n)
Reposted
embl.org
EMBL @embl.org · Sep 1
📢 Recruitment for the EMBL International PhD Programme is officially open!

At EMBL, we train young scientists to become skilled and creative future leaders in academia and other sectors. Join us and get a head start on your career in life sciences!

bit.ly/47mmiFF
Reposted
steglelab.bsky.social
Deadline in 9 days - apply now!
oliverstegle.bsky.social
Job alert: Join us for a postdoc in AI in genetics at @EMBL Heidelberg! Great collaboration with @Adrian Cortes @GSK, aiming to develop new tools to elucidate genetic effects using population-scale cohorts and single-cell readouts. Please share!

embl.wd103.myworkdayjobs.com/de-DE/EMBL/d...
Postdoctoral Researcher in Computational Genetics
The research group of Oliver Stegle looks for a postdoctoral researcher to join a collaborative project with GSK with the goal to apply computational methods to investigate the effects of rare variant...
embl.wd103.myworkdayjobs.com
Reposted
oliverstegle.bsky.social
Job alert: Join us for a postdoc in AI in genetics at @EMBL Heidelberg! Great collaboration with @Adrian Cortes @GSK, aiming to develop new tools to elucidate genetic effects using population-scale cohorts and single-cell readouts. Please share!

embl.wd103.myworkdayjobs.com/de-DE/EMBL/d...
Postdoctoral Researcher in Computational Genetics
The research group of Oliver Stegle looks for a postdoctoral researcher to join a collaborative project with GSK with the goal to apply computational methods to investigate the effects of rare variant...
embl.wd103.myworkdayjobs.com
brianfclarke.bsky.social
We're hiring!

Want use deep learning to discover genetic disease mechanisms and therapeutic targets? Like the sound of applying Bayesian deep learning, DNA language models and federated learning to this exciting problem? Then this position in our group is for you!
PhD Student in Deep Learning for Rare Variant Genetics
jobs.dkfz.de
Reposted
moritzmall.bsky.social
An insightful thread for the second study by the one and only @manusaraswat.bsky.social that spearheaded this superstar team effort together with @lauraruedag.bsky.social and Elisa Heinzelmann in the labs of @oliverstegle.bsky.social and me:
bsky.app/profile/manu...
manusaraswat.bsky.social
🧠 Excited to share my main PhD project! We mapped the regulatory rules governing Glioblastoma plasticity using single-cell multi-omics and deep learning. This work is part of a two-paper series with @bayraktarlab.bsky.social @oliverstegle.bsky.social and @moritzmall.bsky.social, Preprint at end🧵👇
Reposted
bayraktarlab.bsky.social
How does tumour heterogeneity arise? How can we predict cancer cell plasticity? In 2 new studies, we trace #glioblastoma heterogeneity to a spatial cancer cell trajectory w. multimodal cell atlassing bit.ly/4mkrWgs & predict plasticity w. snRNA/ATAC+deep learning bit.ly/3FbI6Ic 🧵
Reposted
manusaraswat.bsky.social
🧠 Excited to share my main PhD project! We mapped the regulatory rules governing Glioblastoma plasticity using single-cell multi-omics and deep learning. This work is part of a two-paper series with @bayraktarlab.bsky.social @oliverstegle.bsky.social and @moritzmall.bsky.social, Preprint at end🧵👇
brianfclarke.bsky.social
The next selection round for the DKFZ International PhD Program has started. Please consider applying to this really excellent program! I'll be proposing projects, as will many other outstanding PIs.
PHD POSITIONS IN
COMPUTATIONAL RESEARCH, DATA SCIENCE
AND ARTIFICIAL INTELLIGENCE

Are you interested in solving fascinating biological or medical questions computationally?
At the German Cancer Research Center (DKFZ), Germany’s largest biomedical research institute with
its core site in Heidelberg, computational scientists work at the forefront of artificial intelligence
and cancer research. They combine inter­ disciplinary approaches from computer science, medical
informatics, physics, biology, bioinformatics and statistics to analyze and understand complex
biological and medical data.

Main activities at the DKFZ involving big data:
•
Development and application of machine
learning and computa­ tional methods for
multi-modal data integration, including
integrative analysis of genomic, epigenomic,
transcriptomic, proteomic, meta­ bolomic and
radiomic imaging data
•
Development of methods for modeling and
simulation of biological and medical processes
•
Medical Informatics

•
•
•
•
DNA mutation analysis and machine learning to
decipher cancer genome variation
Application and development of state-of-the-art
technologies for single-cell omics and life cell
imaging
Computer-assisted radiology and surgery
Biostatistical evaluation of experimental and
clinical data
More information at www.dkfz.de/datascience. Full funding is provided for the duration of the PhD.

To apply online to the International PhD Program visit
To apply online to the International PhD Program visit
www.dkfz.de/phd
Application deadline
24 April 2025

We support and value diversity and encourage applications from individuals
from underrepresented groups. If you require assistance during the application
process, please contact phd@dkfz.de.
Reposted
steglelab.bsky.social
1/ New preprint! 🍳

@elihei.bsky.social and our team at @embl.org , @dkfz.bsky.social, and @mskcancercenter.bsky.social built #segger - a fast, accurate cell segmentation tool for spatial transcriptomics that assigns transcripts to their cell origins!

doi.org/10.1101/2025...
Segger logo Message passing intuition behind the segger’s link-prediction model and the network architecture
Reposted
vitaliikl.bsky.social
Cell2fate learns which genes have co-regulated transcription rates => spatially mapping velocity modules & improved robustness. Bayesian modelling => easier to add biological realism.

Exciting collab with Alexander Aivasidis in Bayraktar & @steglelab.bsky.social

www.nature.com/articles/s41...
Fig 4.
brianfclarke.bsky.social
Exciting job opportunity!👇
A great chance to work on an application of machine learning in human genetics which will make an impact on our understanding of disease and has real potential for future translation to the clinic.
steglelab.bsky.social
📢 Bring your computational expertise to our cutting-edge research team at @embl.org! Join us together with experts from GSK to explore the effects of rare variants using population-scale cohorts and single-cell readouts.
Please share 🙏
🔗 Apply now: embl.wd103.myworkdayjobs.com/de-DE/EMBL/d...
Postdoctoral Researcher in Computational Genetics
The research group of Oliver Stegle looks for a postdoctoral researcher to join a collaborative project with GSK with the goal to apply computational methods to investigate the effects of rare variant...
embl.wd103.myworkdayjobs.com