Christmas quiet times while setting up data collections! Also a bit of @paperkites playing flat out! #cryoem

Excited to share our first foray in ML-guided protein design. With the @gavinjknott lab we designed protein binders as that block heme piracy by pathogenic E. coli and potently inhibit CRISPR-Cas13. www.biorxiv.org/content/10.1..., www.biorxiv.org/content/10.1...

A long-waited refinement tool for cofactors with metal-coordination, MetalCoord. By Garib Murshudov group @mrclmb.bsky.social
Compiles distances & angles from CCP4 monomer library and classifies the metal-coordination geometry. The updated dictionaries and restraints then used for refinement.

My bandmates got me the coooooolest custom mug of all time!

So 999999937 is the last prime number before 10^9....

very cool 😎

#primes

There is much talk about how #peerreview is broken and needs some type of peristroika. However, I just reviewed a manuscript where in the initial review I pointed out what I saw as a bit of flaw. The authors took this very seriously and they resubmission was absolutely fantastic..... 1/2

Join us next Thursday on December 5th @ Stata Center to hear from the main authors behind Boltz-1, Jeremy Wohlwend and @gcorso.bsky.social, about best practices for Boltz-1 and a vision for the exponential progress of AI in life sciences.
🎟️ Register: jclinic.mit.edu/events/boltz...

There are parts of the University of Melbourne campus that definitely feel like they could be from somewhere in England!

Faster and more accurate protein modeling with CryFold. By focusing on nearby points (Local Attention) and employing map masking, CryFold excels in generating models from challenging maps regions. It enables a more cost-efficient model building. 🧵
💾 github.com/SBQ-1999/Cry...

I'm at the #qtml conference. So many Hamiltonians and Unitary transformers! Very, very interesting though. It does however seem like #quantumcomputing is a long way off from helping with #cryoEM calculations.