Alvin Xu
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biobriefing.substack.com
Alvin Xu
@biobriefing.substack.com
Biology student thinking about statistics, mathematics, and science.
https://biobriefing.substack.com/
https://statmethods.substack.com/
Imagine a computer that can translate thought to speech in under 1 second.

Groundbreaking work from UC Berkeley & UCSF uses AI to restore naturalistic, real-time voice for those with severe paralysis, bypassing previous latency hurdles.

#SciSky #MedSky #BCI #Neuroscience #NeuroTech #AI #MedTech
Brain-to-voice neuroprosthesis restores naturalistic speech
Marking a breakthrough, an AI-based model streams intelligible speech from the brain in real-time.
www.universityofcalifornia.edu
February 1, 2026 at 10:57 PM
Research posts on Bluesky are more original — and get better engagement www.nature.com/articles/d41...

#SciSky #AcademicSky #OpenScience #SciComm #SocialMediaAnalysis
Research posts on Bluesky are more original — and get better engagement
Bluesky posts about science garner more likes and reposts than similar ones on X.
www.nature.com
January 31, 2026 at 6:16 AM
Pancreatic cancer is the third deadliest cancer. Treatment often fail due to resistance.

A new study in PNAS led by Mariano Barbacid tackles this with a triple combination therapy that induces robust tumor regression and prevents the onset of tumor resistance in mice.

#SciSky #MedSky #Oncology
A targeted combination therapy achieves effective pancreatic cancer regression and prevents tumor resistance | PNAS
Pancreatic ductal adenocarcinoma (PDAC) has one of the lowest cancer survival rates. Recent studies using RAS inhibitors have opened the door to mo...
www.pnas.org
January 31, 2026 at 2:50 AM
Why did life explode in complexity 538.8 million years ago?

Inspired by a friend's question, I wrote my first Substack deep-dive on the factors that ignited the Cambrian explosion.

Read here: open.substack.com/pub/biobrief...

#ScienceSky #Biology #Evolution #SciComm
January 28, 2026 at 4:24 AM
Mathematical oncology aims to model cancer to improve the delivery and efficacy of therapies. Broadly, models fall into two classes: mechanistic and AI-driven. Mechanistic models can be further divided into continuous and discrete/stochastic approaches.

www.nature.com/articles/s41...
Using mathematical modelling and AI to improve delivery and efficacy of therapies in cancer - Nature Reviews Cancer
Here Harkos et al. review the role of continuous models and discrete models in predicting and understanding therapy delivery and efficacy in solid tumours. They propose ways to integrate mechanistic a...
www.nature.com
January 21, 2026 at 5:41 PM