Richard Benninger
@bennyscience.bsky.social
Bioengineering to cure diabetes. Father of 2. Ski and hike in remaining time. Colorado. 🇺🇦
Benningerlab.com
Benningerlab.com
Nice work Scott!
Type 2 diabetes is often considered a protein misfolding disease. But where are these toxic proteins found? 🤔
🚨In new work out today in @natmetabolism.nature.com, we show that mitochondrial protein misfolding (yes mitos🤯) leads to beta cell damage in T2D. 🚨 nature.com/articles/s42... 1/n
🚨In new work out today in @natmetabolism.nature.com, we show that mitochondrial protein misfolding (yes mitos🤯) leads to beta cell damage in T2D. 🚨 nature.com/articles/s42... 1/n
LONP1 regulation of mitochondrial protein folding provides insight into beta cell failure in type 2 diabetes - Nature Metabolism
LONP1, whose expression is downregulated in islets from donors with type 2 diabetes, is vital to mediate efficient mitochondrial protein folding, thus preventing proteotoxicity and promoting islet β c...
nature.com
July 21, 2025 at 1:10 PM
Nice work Scott!
Check out this pre-print from Vira Kravets, Andraz Stozer and myself, for the influence of alpha cells on heterogenous islet Ca2+ responses, including first-responders and first phase timing/amplitude. Was great to be part of this!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Role of GLP1-receptor-mediated α-β-cell communication in functional β-cell heterogeneity.
While the islet β-cells were traditionally viewed as a singular functional entity, findings of 1970s and up until recent years, reveal that individual β-cells differ in their calcium dynamics and insu...
www.biorxiv.org
April 29, 2025 at 8:59 PM
Check out this pre-print from Vira Kravets, Andraz Stozer and myself, for the influence of alpha cells on heterogenous islet Ca2+ responses, including first-responders and first phase timing/amplitude. Was great to be part of this!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Apparently NIH is seeking to impose a standard 15% indirect cost rate going forward. That will be disruptive to say the least:
grants.nih.gov/grants/guide...
grants.nih.gov/grants/guide...
NOT-OD-25-068: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates NOT-OD-25-068. OD
grants.nih.gov
February 8, 2025 at 12:02 AM
Apparently NIH is seeking to impose a standard 15% indirect cost rate going forward. That will be disruptive to say the least:
grants.nih.gov/grants/guide...
grants.nih.gov/grants/guide...
Check out our ‘Paper of the Month’, led by Anne Gresch. Also coming to a Diabetes podcast soon!
diabetesjournals.org/diabetes/art...
diabetesjournals.org/diabetes/art...
Resolving spatiotemporal electrical signaling within the islet via CMOS microelectrode arrays
Glucose-stimulated beta-cells exhibit synchronized calcium dynamics across the islet that recruit beta-cells to enhance insulin secretion. Compared to calc
diabetesjournals.org
January 29, 2025 at 3:04 AM
Check out our ‘Paper of the Month’, led by Anne Gresch. Also coming to a Diabetes podcast soon!
diabetesjournals.org/diabetes/art...
diabetesjournals.org/diabetes/art...
Hello everyone- I work in diabetes research and will post about our research, but also like to follow and comment on English football (soccer) and American football (football).
November 13, 2024 at 3:38 AM
Hello everyone- I work in diabetes research and will post about our research, but also like to follow and comment on English football (soccer) and American football (football).