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Richard Benninger

@bennyscience.bsky.social

200 followers 160 following 10 posts

Bioengineering to cure diabetes. Father of 2. Ski and hike in remaining time. Colorado. 🇺🇦 Benningerlab.com

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Richard Benninger @bennyscience.bsky.social · Sep 17

Great work Mark, Mohammad and co. Nice to see this out- congratulations!

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Richard Benninger @bennyscience.bsky.social · Jul 21

Nice work Scott!

Scott Soleimanpour @soleimanpourlab.bsky.social · Jul 21

Type 2 diabetes is often considered a protein misfolding disease. But where are these toxic proteins found? 🤔

🚨In new work out today in @natmetabolism.nature.com, we show that mitochondrial protein misfolding (yes mitos🤯) leads to beta cell damage in T2D. 🚨 nature.com/articles/s42... 1/n

LONP1 regulation of mitochondrial protein folding provides insight into beta cell failure in type 2 diabetes - Nature Metabolism

LONP1, whose expression is downregulated in islets from donors with type 2 diabetes, is vital to mediate efficient mitochondrial protein folding, thus preventing proteotoxicity and promoting islet β c...

nature.com

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Richard Benninger @bennyscience.bsky.social · Apr 29

Check out this pre-print from Vira Kravets, Andraz Stozer and myself, for the influence of alpha cells on heterogenous islet Ca2+ responses, including first-responders and first phase timing/amplitude. Was great to be part of this!

www.biorxiv.org/content/10.1...

Role of GLP1-receptor-mediated α-β-cell communication in functional β-cell heterogeneity.

While the islet β-cells were traditionally viewed as a singular functional entity, findings of 1970s and up until recent years, reveal that individual β-cells differ in their calcium dynamics and insu...

www.biorxiv.org

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Richard Benninger @bennyscience.bsky.social · Apr 21

For sure- all the feasible alternatives keep dropping!

Richard Benninger @bennyscience.bsky.social · Feb 8

Apparently NIH is seeking to impose a standard 15% indirect cost rate going forward. That will be disruptive to say the least:
grants.nih.gov/grants/guide...

NOT-OD-25-068: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates

NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates NOT-OD-25-068. OD

grants.nih.gov

Richard Benninger @bennyscience.bsky.social · Jan 29

Check out our ‘Paper of the Month’, led by Anne Gresch. Also coming to a Diabetes podcast soon!
diabetesjournals.org/diabetes/art...

Resolving spatiotemporal electrical signaling within the islet via CMOS microelectrode arrays

Glucose-stimulated beta-cells exhibit synchronized calcium dynamics across the islet that recruit beta-cells to enhance insulin secretion. Compared to calc

diabetesjournals.org

Richard Benninger @bennyscience.bsky.social · Nov 14

Mainly type1 diabetes, but there are a few things relevant type2 as well. But lots of exciting things going on in type1 research at the moment!

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Richard Benninger @bennyscience.bsky.social · Nov 13

Particularly passionate about Colorado, islet biology and microscopy!

Richard Benninger @bennyscience.bsky.social · Nov 13

Hello everyone- I work in diabetes research and will post about our research, but also like to follow and comment on English football (soccer) and American football (football).

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Richard Benninger @bennyscience.bsky.social · Nov 13

Do you miss writing about finance and the railways?