Auclair Lab
@auclairlab.bsky.social
We explore many fields of chemistry and biology (many of them concerning enzymes).
Located at McGill University, Montreal.
Student-ran account: posts not by Dr. Auclair unless indicated.
RP/follow ≠ endorsement.
https://www.auclair-group.mcgill.ca
Located at McGill University, Montreal.
Student-ran account: posts not by Dr. Auclair unless indicated.
RP/follow ≠ endorsement.
https://www.auclair-group.mcgill.ca
Pinned
Auclair Lab
@auclairlab.bsky.social
· Oct 30
NEW PREPRINT:
An extensive structure-activity relationship investigation of pantetheinamides and their ability to inhibit Salmonella typhimurium.
We investigate the mechanisms of action of these compounds and their use with in vivo mouse models.
doi.org/10.1101/2025...
An extensive structure-activity relationship investigation of pantetheinamides and their ability to inhibit Salmonella typhimurium.
We investigate the mechanisms of action of these compounds and their use with in vivo mouse models.
doi.org/10.1101/2025...
Check out some of the great work being done by our collaborators in the Schmeing lab in Biochemistry!
In partnership with the Canadian Light Source's beamline, they're examining the structure and workings of itaconate-degrading enzymes.
#chemsky #biochemsky
www.linkedin.com/posts/canlig...
In partnership with the Canadian Light Source's beamline, they're examining the structure and workings of itaconate-degrading enzymes.
#chemsky #biochemsky
www.linkedin.com/posts/canlig...
#onthebeamlines #bacteria #salmonella #legionella #pseudomonas #yersinia #tuberculosis | Canadian Light Source Inc. / Centre canadien de rayonnement synchrotron
#OnTheBeamlines: Itaconate is a small molecule our immune cells make when fighting bacteria. Some #bacteria, however, fight back: they use a three-step enzyme pathway to break down itaconate so it’s n...
www.linkedin.com
November 29, 2025 at 2:39 PM
Check out some of the great work being done by our collaborators in the Schmeing lab in Biochemistry!
In partnership with the Canadian Light Source's beamline, they're examining the structure and workings of itaconate-degrading enzymes.
#chemsky #biochemsky
www.linkedin.com/posts/canlig...
In partnership with the Canadian Light Source's beamline, they're examining the structure and workings of itaconate-degrading enzymes.
#chemsky #biochemsky
www.linkedin.com/posts/canlig...
Prof. Auclair presented at the McGill Interdisciplinary Initiative in Infection and Immunity (MI4) annual symposium last week!
November 26, 2025 at 2:52 PM
Prof. Auclair presented at the McGill Interdisciplinary Initiative in Infection and Immunity (MI4) annual symposium last week!
Come find us at @concordia.ca Loyola campus for CBGRC this Friday!
November 17, 2025 at 3:16 PM
Come find us at @concordia.ca Loyola campus for CBGRC this Friday!
Reposted by Auclair Lab
NEW PREPRINT:
An extensive structure-activity relationship investigation of pantetheinamides and their ability to inhibit Salmonella typhimurium.
We investigate the mechanisms of action of these compounds and their use with in vivo mouse models.
doi.org/10.1101/2025...
An extensive structure-activity relationship investigation of pantetheinamides and their ability to inhibit Salmonella typhimurium.
We investigate the mechanisms of action of these compounds and their use with in vivo mouse models.
doi.org/10.1101/2025...
October 30, 2025 at 7:54 PM
NEW PREPRINT:
An extensive structure-activity relationship investigation of pantetheinamides and their ability to inhibit Salmonella typhimurium.
We investigate the mechanisms of action of these compounds and their use with in vivo mouse models.
doi.org/10.1101/2025...
An extensive structure-activity relationship investigation of pantetheinamides and their ability to inhibit Salmonella typhimurium.
We investigate the mechanisms of action of these compounds and their use with in vivo mouse models.
doi.org/10.1101/2025...
NEW PREPRINT:
An extensive structure-activity relationship investigation of pantetheinamides and their ability to inhibit Salmonella typhimurium.
We investigate the mechanisms of action of these compounds and their use with in vivo mouse models.
doi.org/10.1101/2025...
An extensive structure-activity relationship investigation of pantetheinamides and their ability to inhibit Salmonella typhimurium.
We investigate the mechanisms of action of these compounds and their use with in vivo mouse models.
doi.org/10.1101/2025...
October 30, 2025 at 7:54 PM
NEW PREPRINT:
An extensive structure-activity relationship investigation of pantetheinamides and their ability to inhibit Salmonella typhimurium.
We investigate the mechanisms of action of these compounds and their use with in vivo mouse models.
doi.org/10.1101/2025...
An extensive structure-activity relationship investigation of pantetheinamides and their ability to inhibit Salmonella typhimurium.
We investigate the mechanisms of action of these compounds and their use with in vivo mouse models.
doi.org/10.1101/2025...
We're incredibly proud to announce Dr. Jacob Pierscianowski has officially defended his PhD thesis!
Congratulations to Dr. Jake on the amazing work.
Congratulations to Dr. Jake on the amazing work.
October 10, 2025 at 6:40 PM
We're incredibly proud to announce Dr. Jacob Pierscianowski has officially defended his PhD thesis!
Congratulations to Dr. Jake on the amazing work.
Congratulations to Dr. Jake on the amazing work.
Good Wordle yesterday.
October 8, 2025 at 3:38 PM
Good Wordle yesterday.
Update: purified it anyways. Fraction looks reasonably pure. Now let's see the activity tests. #chemsky
Admin got up yesterday at 7 in the morning to perform a transformation that probably didn't work. One (1) colony on the plates. This is the #chembiosky life.
October 4, 2025 at 10:12 PM
Update: purified it anyways. Fraction looks reasonably pure. Now let's see the activity tests. #chemsky
The Auclair Lab welcomes two new members!
Maya Gaylor, co-supervised by Prof. Lupien in Microbiology and Immunology, will be working on our antimicrobial projects.
Dr. Alana Rangaswamy is a recent graduate from the Keillor lab @uottawa.ca and will focus on enzyme and depolymerization efforts.
Maya Gaylor, co-supervised by Prof. Lupien in Microbiology and Immunology, will be working on our antimicrobial projects.
Dr. Alana Rangaswamy is a recent graduate from the Keillor lab @uottawa.ca and will focus on enzyme and depolymerization efforts.
October 3, 2025 at 6:10 PM
The Auclair Lab welcomes two new members!
Maya Gaylor, co-supervised by Prof. Lupien in Microbiology and Immunology, will be working on our antimicrobial projects.
Dr. Alana Rangaswamy is a recent graduate from the Keillor lab @uottawa.ca and will focus on enzyme and depolymerization efforts.
Maya Gaylor, co-supervised by Prof. Lupien in Microbiology and Immunology, will be working on our antimicrobial projects.
Dr. Alana Rangaswamy is a recent graduate from the Keillor lab @uottawa.ca and will focus on enzyme and depolymerization efforts.
Admin got up yesterday at 7 in the morning to perform a transformation that probably didn't work. One (1) colony on the plates. This is the #chembiosky life.
September 23, 2025 at 3:08 PM
Admin got up yesterday at 7 in the morning to perform a transformation that probably didn't work. One (1) colony on the plates. This is the #chembiosky life.
Fun fact: we scheduled our lab cleanup day a few weeks ago, and the second we finished up, we got a notification that we were having a safety inspection the very next Monday.
Talk about good timing #chemsky
Talk about good timing #chemsky
September 19, 2025 at 10:11 PM
Fun fact: we scheduled our lab cleanup day a few weeks ago, and the second we finished up, we got a notification that we were having a safety inspection the very next Monday.
Talk about good timing #chemsky
Talk about good timing #chemsky
Doing a little setup for our new baby 👀
September 4, 2025 at 1:23 PM
Doing a little setup for our new baby 👀
New instrument 🔜🔜🔜
September 3, 2025 at 4:23 PM
New instrument 🔜🔜🔜
Sign up for McGill Chemistry's Careers After Chemistry 2025 conference! Registration ends September 5.
cacmcgill.wixsite.com/cac2025/regi...
cacmcgill.wixsite.com/cac2025/regi...
Register | CAC 2025
cacmcgill.wixsite.com
August 29, 2025 at 5:58 PM
Sign up for McGill Chemistry's Careers After Chemistry 2025 conference! Registration ends September 5.
cacmcgill.wixsite.com/cac2025/regi...
cacmcgill.wixsite.com/cac2025/regi...
The Auclair lab went tree trekking recently! Super fun teambuilding exercise.
August 28, 2025 at 2:34 PM
The Auclair lab went tree trekking recently! Super fun teambuilding exercise.
Very happy to meet 2020 Nobel Prize laureate @e-charpentier.bsky.social at @ircm.bsky.social!
August 20, 2025 at 2:48 PM
Very happy to meet 2020 Nobel Prize laureate @e-charpentier.bsky.social at @ircm.bsky.social!
Reposted by Auclair Lab
‼️NEW PAPER ALERT
In Antimicrobial Agents and Chemotherapy, we replace an enzyme-vulnerable amide bond with a thiazole to produce potent antiplasmodial and antimalarial pantothenamide mimics. A collaboration between the Auclair lab @mcgill.ca and the Saliba lab at ANU.
doi.org/10.1128/aac....
🧵
In Antimicrobial Agents and Chemotherapy, we replace an enzyme-vulnerable amide bond with a thiazole to produce potent antiplasmodial and antimalarial pantothenamide mimics. A collaboration between the Auclair lab @mcgill.ca and the Saliba lab at ANU.
doi.org/10.1128/aac....
🧵
August 13, 2025 at 5:10 PM
‼️NEW PAPER ALERT
In Antimicrobial Agents and Chemotherapy, we replace an enzyme-vulnerable amide bond with a thiazole to produce potent antiplasmodial and antimalarial pantothenamide mimics. A collaboration between the Auclair lab @mcgill.ca and the Saliba lab at ANU.
doi.org/10.1128/aac....
🧵
In Antimicrobial Agents and Chemotherapy, we replace an enzyme-vulnerable amide bond with a thiazole to produce potent antiplasmodial and antimalarial pantothenamide mimics. A collaboration between the Auclair lab @mcgill.ca and the Saliba lab at ANU.
doi.org/10.1128/aac....
🧵
Reposted by Auclair Lab
Another day, another paper 😌
‼️NEW PAPER ALERT
In Antimicrobial Agents and Chemotherapy, we replace an enzyme-vulnerable amide bond with a thiazole to produce potent antiplasmodial and antimalarial pantothenamide mimics. A collaboration between the Auclair lab @mcgill.ca and the Saliba lab at ANU.
doi.org/10.1128/aac....
🧵
In Antimicrobial Agents and Chemotherapy, we replace an enzyme-vulnerable amide bond with a thiazole to produce potent antiplasmodial and antimalarial pantothenamide mimics. A collaboration between the Auclair lab @mcgill.ca and the Saliba lab at ANU.
doi.org/10.1128/aac....
🧵
August 13, 2025 at 5:13 PM
Another day, another paper 😌
‼️NEW PAPER ALERT
In Antimicrobial Agents and Chemotherapy, we replace an enzyme-vulnerable amide bond with a thiazole to produce potent antiplasmodial and antimalarial pantothenamide mimics. A collaboration between the Auclair lab @mcgill.ca and the Saliba lab at ANU.
doi.org/10.1128/aac....
🧵
In Antimicrobial Agents and Chemotherapy, we replace an enzyme-vulnerable amide bond with a thiazole to produce potent antiplasmodial and antimalarial pantothenamide mimics. A collaboration between the Auclair lab @mcgill.ca and the Saliba lab at ANU.
doi.org/10.1128/aac....
🧵
August 13, 2025 at 5:10 PM
‼️NEW PAPER ALERT
In Antimicrobial Agents and Chemotherapy, we replace an enzyme-vulnerable amide bond with a thiazole to produce potent antiplasmodial and antimalarial pantothenamide mimics. A collaboration between the Auclair lab @mcgill.ca and the Saliba lab at ANU.
doi.org/10.1128/aac....
🧵
In Antimicrobial Agents and Chemotherapy, we replace an enzyme-vulnerable amide bond with a thiazole to produce potent antiplasmodial and antimalarial pantothenamide mimics. A collaboration between the Auclair lab @mcgill.ca and the Saliba lab at ANU.
doi.org/10.1128/aac....
🧵
