Joint multi-omics profiling of brain and body health in aging https://www.biorxiv.org/content/10.1101/2025.10.09.681483v1

Huge thanks to Sanjay Kalra and the CALSNIC team, J Hansen, @vincebaz.bsky.social @goliashf.bsky.social L Collins @dadarmahsa.bsky.social @alaindagher.bsky.social !!

code: github.com/netneurolab/...

Network spreading and local biological vulnerability in amyotrophic lateral sclerosis |
doi.org/10.1038/s420...

How do brain network structure and local biological features shape the spatial patterning of atrophy in ALS? @asafarahani.bsky.social investigates ⤵️

The effect of spherical projections on spin tests for brain maps | doi.org/10.1162/IMAG...

Spin tests are the de facto null model for map-to-map comparisons in brain imaging. Why don't they perfectly control false positives? @vincebaz.bsky.social explores ⤵️

🧠Brain network structure and local biology jointly shape ALS atrophy. Disease epicenters show transcriptomic enrichment for mitochondrial function, endothelial cells and pericytes. Individual variation in epicenters aligns with clinical symptoms.

doi.org/10.1038/s420...

Mapping cerebral blood perfusion and its links to multi-scale brain organization across the human lifespan | doi.org/10.1371/jour...

How does blood perfusion map onto canonical features of brain structure and function? @asafarahani.bsky.social investigates @plosbiology.org ⤵️

How does cerebral #BloodPerfusion map onto micro-, meso- & macro-scale brain structure? @asafarahani.bsky.social @misicbata.bsky.social &co characterize blood perfusion in the #HumanBrain, revealing how it changes with age & in #NeurodegenerativeDisease @plosbiology.org 🧪 plos.io/46AEURS

Take a look at the preprint, specifically, if you like one of the followings:

Frontal cortex
Face/social processing
Individual variability
Sulci depth
And movies !!! 🎥

Subtyping subjects can be an intermediate step that fills the gap between generalized and idiosyncratic organization of brain maps.

FFPs are interconnected to mSTS, are very much face responsive, and love social cues! 👽

We identify two groups of subjects who showed a remarkable difference in the topographical organization of FFPs! 👥

“A network of face patches in human prefrontal cortex for social processing of faces”

www.biorxiv.org/content/10.1...

Let us characterize a novel network of four frontal face patches (FFPs) arranged dorsoventrally in the human lateral prefrontal cortex! 🔢

New: Energy use shapes brain organization and development. We use gene expression maps from the @alleninstitute.bsky.social Human Brain Atlas to map the main energy metabolism pathways in the brain. Led by @moohebatpe.bsky.social @misicbata.bsky.social @goliashf.bsky.social and Justine Hansen 🧵

I am excited to share that my undergraduate research has now been accepted to #ICLR2025.
📎: openreview.net/pdf?id=wMgr7...
🧑‍💻: github.com/BashivanLab/...

Tweeprint🧵⬇️

Cerebral blood perfusion across biological systems and the human lifespan | doi.org/10.1101/2025...

How does blood perfusion map onto canonical features of brain structure and function? @asafarahani.bsky.social investigates ⤵️