Background Although radiofrequency ablation is effective for treating left ventricular papillary muscle (PM) arrhythmias, procedural complications like catheter entrapment and risk of PM injury are .....

Background Abdominal aortic aneurysm (AAA) is an abnormal dilation of the abdominal aorta that carries up to a 90% mortality rate when ruptured. Although male patients experience AAA at a higher rate ...

BACKGROUND: Familial hypercholesterolemia (FH) is an autosomal dominant genetic disorder that increases risk for premature coronary artery disease and has accessible and effective interventions. The D...

There is a fundamental knowledge gap regarding the effects of neonatal hyperoxia-exposure on the systemic vasculature and its repercussions on the cardio-pulmonary system. Neonatal hyperoxia exposure ...

Mitochondrial transplantation has emerged as a promising cardioprotective strategy for ischemia–reperfusion injury, aiming to restore bioenergetic fun…

Abstract. Computational fluid dynamics (CFD) is commonly used to investigate hemodynamics in the cardiovascular system, particularly in regions prone to cardiovascular disease such as the carotid arte...

Photoacoustic imaging (PAI) is an emerging imaging modality that provides high-resolution, spatiotemporal insights into anatomical structures, functional parameters and molecular characteristics of t...

Clozapine is an effective antipsychotic medication for the management of treatment-resistant schizophrenia. However, the use of clozapine is limited due to severe and sometimes fatal adverse events, i...

In situ vascular tissue engineering aims to create living blood vessel replacements from biodegradable scaffolds. The functionality of these tissue-engineered vascular grafts (TEVGs) has often been li...

Scientific Reports - Aortic calcification is associated with decreased abdominal aortic aneurysm growth

Purpose Borderline left ventricle (BLV) presents a dilemma between pursuing a biventricular repair (BiVR) and a Stage 1 palliation (S1P) because a discordant pursuit of BiVR increases mortality risk. ...

The mechanical impact of the gravid uterus on the vasculature is well known, but its role in hypertensive disorders of pregnancy (HDP) is incompletely understood. Prior studies have demonstrated an...

The cardiovascular system adapts to meet rising physiological demands throughout pregnancy. Notably, the left ventricle grows to support this increased workload, which is thought to reverse after deli...

Novel approaches employing various polymer architectures and synthetic biomaterials are readily utilized for therapeutic angiogenesis. In this study, water-soluble glucose-based poly(1-O-methacryloyl-D-glucose) (PGl), maltose-based poly(1-O-methacryloyl-D-maltose) (PMa) homopolymers, and their corre …

Abstract figure legend Traditional planar imaging approaches of the left atrium do not capture complex geometry. Four-dimensional imaging allows the acquisition of 3D data + time to visualize left at....

During wound healing, fibroblasts undergo radical processes that impact their phenotype and behavior. They are activated, recruited to the injury site…

We have developed a unique method for pre-clinical heart valve prostheses evaluation of calcification propensity. Results from the test can directly be translated into improvements of prostheses desi...

Scanning multiphoton imaging of an intracranial aneurysm revealed a vasa vasorum plexus with both positive and deleterious roles.

Abstract. Endothelial to mesenchymal transition (EndMT) is a process whereby endothelial cells transition to adopt a mesenchymal-like fate, e.g. to become

Purpose of Review To provide an overview of human induced pluripotent stem cell (hiPSC)-derived cardiovascular lineages and describe their impact on drug testing in vitro. Recent Findings hiPSCs have ...

Treatment IC7Fc targets hepatic regulation of lipid metabolism and inflammation, ameliorating atherosclerosis in mice.

The advancement of electrophysiological mapping for cardiac arrhythmias relies critically on overcoming key interface challenges: long-term biocompatibility, spatial resolution limitations, and mechanical mismatch with dynamic cardiac tissue. To address these, we developed a rapid encapsulation method for liquid metal electrode arrays at the 10-μm scale, enabling the fabrication of ultrahigh-density and flexible sensor arrays (∼28570 sensors/cm2) within 30 min. It constructs a fully foldable, high-density heart–machine interface deployable via minimally invasive access (<3 mm folded diameter). The interface achieves high-resolution imaging (in rat, rabbit, and dog models) of microscale electrical heterogeneity (e.g., 0.2 mm2 reentrant pattern in ventricular fibrillation) while maintaining long-term reliability (100% electrode functionality over 98 days). This technology holds promise for advancing diverse human–machine interfaces for other organs and tissues, enabling the integration of multiple organs and even the whole body for comprehensive health management.

Tricuspid regurgitation (TR), once seen as benign, is now recognized as a serious and increasingly prevalent condition linked to aging and better imaging. Its association with greater morbidity and m....