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microbiotech : The Tischler Lab @tischlerlab.bsky.social · 14d

Congrats Pravin et al! well done !!!

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microbiotech : The Tischler Lab @tischlerlab.bsky.social · 14d

news.rub.de/english/pres...

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Reposted by microbiotech : The Tischler Lab

Dirk Tischler @dirktischler.bsky.social · 15d

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Giftiges Styroloxid in attraktive Verbindung umwandeln

Die Styroloxid-Isomerase entpuppt sich als multifunktioneller Helfer für die Biotechnologie.

news.rub.de

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microbiotech : The Tischler Lab @tischlerlab.bsky.social · 14d

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Converting toxic styrene oxide into attractive compounds

Styrene oxide isomerase is proving to be a multifunctional helper for biotechnology.

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microbiotech : The Tischler Lab @tischlerlab.bsky.social · Sep 16

Just before the next semester starts our MBT team got together to plan teaching and group activities for the comming month! Such a great team of young innovative people!

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microbiotech : The Tischler Lab @tischlerlab.bsky.social · Sep 11

Characterization of the N‐Hydroxylating Monooxygenase TheA from Thermocrispum agreste Reveals a Broad Substrate Spectrum - Maier - ChemBioChem - Wiley Online Library chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...

Characterization of the N‐Hydroxylating Monooxygenase TheA from Thermocrispum agreste Reveals a Broad Substrate Spectrum

TheA is a moderate thermostable flavin-dependent monooxygenase which accepts, besides l-ornithine a number of related molecules for the regio-selective N-hydroxylation. The combination with a NADP+-r...

chemistry-europe.onlinelibrary.wiley.com

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Dirk Tischler @dirktischler.bsky.social · Sep 2

#epoxidation by means of #enzymes provides a plethora of interesting #molecules! still many questions remain to be solved, here we provide a perspective on potential #biotransformations and open questions: Cell Reports Physical Science www.cell.com/cell-reports...

Enzymatic epoxidation strategies for the stereoselective synthesis of chiral epoxides

Chiral epoxides are essential building blocks in the pharmaceutical and chemical industries. This perspective examines both established and emerging enzymatic pathways, highlights recent advancements,...

www.cell.com

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microbiotech : The Tischler Lab @tischlerlab.bsky.social · Aug 29

With co-authorship from our lab - @annarchist08.bsky.social and @dirktischler.bsky.social:

#biotransforamtion #enzymology #biotechnology #C1 #C1metabolism #CO2 #synbio

rdcu.be/eC3Es

Industrial applicability of enzymatic and whole-cell processes for the utilization of C1 building blocks

Nature Communications - Significant process has been made in using one carbon sources toward biomanufacturing. Here, the authors explore how to strength its competitiveness, and highlight latest...

rdcu.be

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Dirk Tischler @dirktischler.bsky.social · Aug 29

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Müll zu Wertstoffen umbauen

Statt fossilen Rohstoffen wollen Forschende Abfälle aufwerten, um den CO2-Ausstoß einzudämmen.

news.rub.de

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microbiotech : The Tischler Lab @tischlerlab.bsky.social · Jul 22

The promiscuous N-hydroxylating monooxygenase GorA and its application in cascades: Cell Reports Physical Science www.cell.com/cell-reports...

The promiscuous N-hydroxylating monooxygenase GorA and its application in cascades

Artur Maier et al. demonstrate the selective hydroxylation of N moieties of various compounds by means of enzymatic cascades. The so formed N-hydroxy compounds can be isolated and applied in synthesis...

www.cell.com

microbiotech : The Tischler Lab @tischlerlab.bsky.social · Jul 8

A real team work; amazing !!! congrats to our team members and the collaboration partners ;-)

Dirk Tischler @dirktischler.bsky.social · Jul 7

Just moved online:

Glutathione S-Transferase Mediated Epoxide Conversion: Functional and Structural Properties of an Enantioselective Catalyst | ACS Catalysis pubs.acs.org/doi/10.1021/...

Glutathione S-Transferase Mediated Epoxide Conversion: Functional and Structural Properties of an Enantioselective Catalyst

Styrene is a naturally occurring but mainly anthropogenically produced aromatic compound. It is degraded via different routes in nature but often activated to styrene oxide, predominantly to its (S)-e...

pubs.acs.org

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microbiotech : The Tischler Lab @tischlerlab.bsky.social · Jun 25

amazing event ... the group is proud and parties ;-)

Dirk Tischler @dirktischler.bsky.social · Jun 25

congrats Dr. Selvapravin Kumaran, it was a long journey with an excellent 👌 disputation at the end! well done 👏🎉

the biochemistry of membrane proteins which can act in degradation or biocatalysis can be complex, you mastered it.

looking forward to the next impact

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microbiotech : The Tischler Lab @tischlerlab.bsky.social · May 27

Big congrats to @danieleggerichs.bsky.social !!! Amazing 😱 You deserve it and we are looking forward to celebrate it together !!!

Dirk Tischler @dirktischler.bsky.social · May 26

Proud PI 🎉 congrats @danieleggerichs.bsky.social, enthusiasm and hard work pays off 👏🎊😉

Gesellschaft Deutscher Chemiker (GDCh) @gdch.de · May 22

Gratulation: Auf dem Science Forum Chemisty (SFC) zeichnet die GDCh Siegfried R. Waldvogel mit dem Wöhler-Preis für Nachhaltige Chemie und Daniel Eggerichs mit dem Preis für Biokonversion nachwachsender Rohstoffe aus. gdch.app/article/scie...

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Dirk Tischler @dirktischler.bsky.social · May 12

Press Release for our latest publication in @pubs.acs.org ACS Catalysis

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New Agents with Genome Mining and Mutagenesis

A German-Dutch research group has expanded the toolkit for potential medications.

news.rub.de

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Dirk Tischler @dirktischler.bsky.social · May 12

Access to Nitrogen–nitrogen Bond-Containing Heterocycles Through Substrate Promiscuity of Piperazate Synthases | ACS Catalysis pubs.acs.org/doi/10.1021/...

Access to Nitrogen–nitrogen Bond-Containing Heterocycles Through Substrate Promiscuity of Piperazate Synthases

The nitrogen–nitrogen (N–N) bond motif comprises an important class of compounds for drug discovery. Synthetic methods are primarily based on the modification of N–N or N═N precursors, whereas selecti...

pubs.acs.org

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microbiotech : The Tischler Lab @tischlerlab.bsky.social · May 13

Congrats on this new story:

Access to Nitrogen–nitrogen Bond-Containing Heterocycles Through Substrate Promiscuity of Piperazate Synthases | ACS Catalysis pubs.acs.org/doi/10.1021/...

Access to Nitrogen–nitrogen Bond-Containing Heterocycles Through Substrate Promiscuity of Piperazate Synthases

The nitrogen–nitrogen (N–N) bond motif comprises an important class of compounds for drug discovery. Synthetic methods are primarily based on the modification of N–N or N═N precursors, whereas selecti...

pubs.acs.org

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Reposted by microbiotech : The Tischler Lab

Dirk Tischler @dirktischler.bsky.social · Apr 9

Spoiler, there will soon be a new book on the shelf with focus on #enzymology #enzyme #application #biocatalysis ... stay tuned as more details I will share on short notice 😊

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Lennart Schada von Borzyskowski @lennartschada.bsky.social · Mar 23

@dirktischler.bsky.social is opening the @vaam-microbes.bsky.social conference 2025 at @ruhr-uni-bochum.de. Looking forward to three days of presentations, posters, and networking!

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microbiotech : The Tischler Lab @tischlerlab.bsky.social · Jan 27

Wonderful to see it now in printed version! @danieleggerichs.bsky.social started and we will continue to understand this #enzyme in more detail (more #enzymology to come) as well as to apply it (more #biocatalysis to come)

Dirk Tischler @dirktischler.bsky.social · Jan 25

The last research article of @danieleggerichs.bsky.social PhD thesis was just published, supported by wonderful collaboration with the @mattevilab.bsky.social it's part of a special collection for #flavins and #flavoproteins, and we report on a #flavin #oxidase
www.sciencedirect.com/science/arti...

Kinetic and structural investigation of the 4-allyl syringol oxidase from Streptomyces cavernae

4-Phenol oxidases are proposed to be involved in the utilization of lignin-derived aromatic compounds. While enzymes with selectivity towards 4-hydrox…

www.sciencedirect.com

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microbiotech : The Tischler Lab @tischlerlab.bsky.social · Jan 27

Congrats from the team!

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microbiotech : The Tischler Lab @tischlerlab.bsky.social · Jan 23

Are you a #youngresearcher working in #biocatalysis? Do you want to share your work with #internationalscientists? Come to the #nextgenbiocat 8-9 of May in Milan!
nextgenbiocat.org

NextGenBiocat

Visit the post for more.

nextgenbiocat.org

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microbiotech : The Tischler Lab @tischlerlab.bsky.social · Jan 22

a book chapter by @carmg.bsky.social from our team moved online; congrats! Cytochrome P450 monooxygenases in whole-cell format: Application notes... www.sciencedirect.com/science/arti...

Cytochrome P450 monooxygenases in whole-cell format: Application notes from a biotechnological perspective

Cytochrome P450 monooxygenases (CYPs) are versatile heme-containing enzymes found across a diverse range of organisms. They play essential roles in hy…

www.sciencedirect.com

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microbiotech : The Tischler Lab @tischlerlab.bsky.social · Jan 20

A book chapter from our team was just published; it is about #enzymes #oxidases #screening #phylogeny #predictivebiotechnology #enzymeengineering ... congrats Nils @ et al ;-)

www.sciencedirect.com/science/arti...

Sequence-function relation for the prediction of enzyme properties: A case study on flavin-dependent oxidases

The discovery of enzymes (biocatalysts) can sometimes be challenging. Herein, we describe an approach for connecting phylogenetic information and mult…

www.sciencedirect.com

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Reposted by microbiotech : The Tischler Lab

Johannes Eckert @futureasapresent.org · May 28

" 'Diese [Alkohole] wiederum nutzen wir dann für Bakterien oder isolierte Enzyme als Substrat für die Herstellung verschiedener Zielprodukte, die für Kosmetika oder Kunststoffe genutzt werden können', so Carolin Mügge" news.rub.de/presseinform...

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microbiotech : The Tischler Lab @tischlerlab.bsky.social · Jan 14

Great to see this online, were @danieleggerichs.bsky.social and @dirktischler.bsky.social contributed !!! #enzymology #biocatalysis for @acs.org catalysis

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