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Karen 金継ぎ et al

@shaytalis.bsky.social

190 followers 280 following 990 posts

Not On X TPIIFAAVDIA.Not for work.Verb account.Plural,trans female,furry,80/90s kids,She/Her/They(sys),18+UBI and rent controlled housing.No fear that you must mask to live.End war. WE use Poetic Alt Text! System:金継ぎ et al Pacman pops power pills g2k🏳️‍⚧️🏳️‍🌈42xp

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Karen 金継ぎ et al @shaytalis.bsky.social · 15d

Update:

Things got hot for a bit, but we seem to have turned the temperature down in our local area somewhat. Not frosty, but pretty cool.

Karen 金継ぎ et al @shaytalis.bsky.social · 1h

You are always so solid with your reporting thank you.

Reposted by Karen 金継ぎ et al

Chise @sailorrooscout.bsky.social · 2d

The study has been published in Nature. YES, it is PEER-REVIEWED.
• www.nature.com/articles/s41...

🧪🧵⬇️

Summary
A groundbreaking study reveals that cancer patients who received a COVID-19 mRNA vaccine within 100 days of starting immunotherapy lived dramatically longer than those who didn't. Researchers from the University of Florida and MD Anderson Cancer Center discovered that the vaccine's immune-activating properties may boost cancer-fighting responses, acting like a nonspecific "flare" that reawakens the immune system.
The work was funded by the National Cancer Institute and foundations. Sayour, Grippin and Mitchell are listed as inventors of patents related to UF-developed mRNA vaccines licensed to iOncologi Inc., a university spinout company.

Abstract
Immune checkpoint inhibitors (ICIs) extend survival in many patients with cancer but are ineffective in patients without pre-existing immunity.
Although personalized mRNA cancer vaccines sensitize tumours to Cls by directing immune attacks against preselected antigens, personalized vaccines are limited by complex and time-intensive manufacturing processes.
Here we show that mRNA vaccines targeting SARS-CoV-2 also sensitize tumours to ICIs. In preclinical models, SARS-CoV-2 mRNA vaccines led to a substantial increase in type I interferon, enabling innate immune cells to prime CD&+ T cells that target tumour-associated antigens. Concomitant ICI treatment is required for maximal efficacy in immunologically cold tumours, which respond by increasing PD-L1 expression.
Similar correlates of vaccination response are found in humans, including increases in type I interferon, myeloid-lymphoid activation in healthy volunteers and PD-L1 expression on tumours. Moreover, receipt of SARS-CoV-2 mRNA vaccines within 100 days of initiating ICI is associated with significantly improved median and three-year overall survival in multiple large retrospective cohorts. This benefit is similar among patients with immunologically cold tumours.
Together, these results demonstrate that clinically available mRNA vaccines targeting non-tumour-related antigens are potent immune modulators capable of sensitizing tumours to ICIs.

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Karen 金継ぎ et al @shaytalis.bsky.social · 1h

HOW?

Reposted by Karen 金継ぎ et al

Chise @sailorrooscout.bsky.social · 2d

GOOD NEWS! A groundbreaking study of MORE THAN 1,000 people reveals that cancer patients who received a COVID-19 mRNA vaccine within 100 days of starting immunotherapy lived dramatically longer than those who didn’t. In some cases, their survival rate was DOUBLED.

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Reposted by Karen 金継ぎ et al

Chiitan🌈ちぃたん☆ @chiitan.love · 28d

Everyone has the right to love and be loved, regardless of gender.
No one can infringe on the ability to express love
Something so simple has become complicated in our world
Let's all raise our voices to solve this problem and create a world where we can express love freely and openly.
we have love♡

71 2.1K 7.1K

Reposted by Karen 金継ぎ et al

emperor of furry edelgards @mousegard.bsky.social · 6h

this halloween is the 10 year anniversary of the day i started publishing fic on ao3. what should i do to celebrate it on that day

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Karen 金継ぎ et al @shaytalis.bsky.social · 6h

Publish fic on ao3 obviously, but it should be something with tons of callbacks and Halloween themed. Make a Halloween episode.

Karen 金継ぎ et al @shaytalis.bsky.social · 6h

ko-fi.com/adalore/goal... If you can chip in at all, @adalore.bsky.social has been there for us for a long time and treated us with the utmost respect. Wonderful person, wonderful art, storytelling, has a fantastic universe for the Manatear comics, please check him out!