Author | Lightnews

Reposted by Sarah Gorey

NEJM.org @nejm.org · 19d

For a student with strep throat and an unconfirmed penicillin allergy, would you prescribe a nonpenicillin antibiotic or give penicillin under doctor supervision? Read the case vignette and essays on both treatment options and cast your vote: nej.md/48eHjm9

#MedSky #MedEd

An illustration of a patient with strep throat, a box of penicillin, and the patient's medical record

3 5

Reposted by Sarah Gorey

CORE IM @coreimpodcast.bsky.social · 21d

1/ 🚨 NEW #BeyondJournalClub w/ @NEJMGroup: The Bolland study

Question: Does infrequent zoledronate therapy in patients without osteoporosis prevent fractures?

Answer: ⤵️

www.coreimpodcast.com/2025/10/01/b...

1 3 6

Sarah Gorey @sarahgorey.bsky.social · Sep 4

Well done @cpkotanidis.bsky.social ! Also check out our manuscript in @annalsofim.bsky.social url.us.m.mimecastprotect.com/s/kNYpCDkAO2...

1 2

Reposted by Sarah Gorey

Peer Review Congress #PRC10 @peerreviewcongress.bsky.social · Sep 4

2.2.1
In an RCT comparing 'uselessly elongated' vs shorter #PeerReview of @neuripsconf.bsky.social 2022 submissions, the longer reviews received higher quality scores, suggesting a length bias among reviewers, w implications for #LLM-generated reviews
journals.plos.org/pl...
@scsatcmu.bsky.social

Evaluators exhibited a significant elongated review bias (P < .001). Elongated reviews received a mean score of
4.29 vs. 3.73 for original reviews. Each individual criterion also showed length bias (P < .05).

3 9

Reposted by Sarah Gorey

Peer Review Congress #PRC10 @peerreviewcongress.bsky.social · Sep 4

In the med literature, statements like “to our knowledge [TOK], this is the FIRST...” often replace a proper systematic search. Among 4488 PMC articles in 6 leading medical journals published 2020-2024, TOK prevalence was 21.7%, w @PLOSMedicine highest (48.4%) and @NEJM lowest (1.3%) #CornellVet

In 2 journals, Journal of Small Animal Practice (JSAP) and Journal of Exotic Pet Medicine (JEPM), an intervention to advise authors against use of these phrases and in favor of a scoping search of the literature was implemented in 2020, w decreases from 37.4% to 7.6% after the intervention.

1 3 7

Reposted by Sarah Gorey

Chris Kotanidis @cpkotanidis.bsky.social · Jul 31

The win ratio method is gaining traction in #RCTs. Is it just a trend or a smarter way to look at composite hierarchical outcomes? We break it down in our latest Stats, STAT!📊 in NEJM Evidence. youtube.com/watch?v=jKtF... #stats @nejm.org @sarahgorey.bsky.social @chardin.bsky.social @ai.nejm.org

How Win Ratios Work | NEJM Evidence

YouTube video by NEJM Group

youtube.com

4 4 15

Reposted by Sarah Gorey

Blue Planet Society @blueplanetsociety.bsky.social · Jun 2

Irish whale watching business closes after 25 years. 🐳

“There are only a few whales left - the water is overfished.”

The owner was previously a commercial fisher but gave up when fish stocks crashed. “It wasn’t something I wanted to be a part of.” 🎣❌
www.irishtimes.com/ireland/2025...

‘It’s an empty, lifeless sea’: Whales leave Cork waters, putting watchers out of business

Stocks of sprat have crashed, forcing whales away, says businessman whose livelihood has been ruined

www.irishtimes.com

2 20 41

Sarah Gorey @sarahgorey.bsky.social · May 28

🐈🐕📈📉👩‍💻🛋️

NEJM.org @nejm.org · May 28

The latest Stats, STAT! animated video from NEJM Evidence describes the use of restricted mean survival time in survival analysis when the proportional hazards assumption is not met.

📺 Full video and transcript: eviden.cc/42YS8FQ

#StatsSky #Statistics

3

Reposted by Sarah Gorey

NEJM.org @nejm.org · May 19

In the BATURA trial, as-needed albuterol–budesonide resulted in a lower risk of severe asthma exacerbation than as-needed albuterol among participants with disease that was uncontrolled despite treatment for mild asthma. Full trial results: nej.md/43uVpwK

#ATS2025 @atscommunity.bsky.social

A graph showing the first severe asthma exacerbation, assessed in a time-to-event analysis, in the on-treatment efficacy population (primary end point)

2 10

Reposted by Sarah Gorey

NEJM.org @nejm.org · May 21

BRIDGE-TNK trial: Among 550 patients with stroke due to large-vessel occlusion who had presented within 4.5 hours after onset, 90-day functional outcomes were better with intravenous tenecteplase before thrombectomy than with thrombectomy alone. nej.md/3GTVKAk

#ESOC2025 @esostroke.bsky.social

A figure showing the distribution of scores on the modified Rankin scale at 90 days in the intention-to-treat population

2 11

Sarah Gorey @sarahgorey.bsky.social · May 6

Really enjoying @cpkotanidis.bsky.social’s fascinating presentation on his interesting work at @brighamandwomens.bsky.social on identifying risk markers of CVD in patients with IMIDs 🤩👏👏👏

1 1 3

Reposted by Sarah Gorey

NEJM.org @nejm.org · May 2

For a woman with device-detected atrial fibrillation, would you initiate anticoagulant therapy or recommend continuation of antiplatelet therapy? Read the case vignette and essays on both treatment options and cast your vote: nej.md/4lQzxTA

#MedSky #CardioSky #Afib

CLINICAL DECISIONS
Anticoagulation or Antiplatelet Therapy for Device-Detected Atrial Fibrillation

An illustration of a smartwatch monitoring ECG and two bottles, one containing an anticoagulant, and the other containing aspirin

3 6 9

Reposted by Sarah Gorey

NEJM.org @nejm.org · Apr 27

Both clonal hematopoiesis of indeterminate potential (CHIP) and cancer are more common with age. When they coexist in the same patient, CHIP cells may migrate to the tumor and have an adverse effect on overall survival. Full study results: nej.md/3EnzMVu

#MedSky #Hematology

A schematic representation of clonal hematopoiesis of indeterminate potential (CHIP) and tumor-infiltrating clonal hematopoiesis (TI-CH) in a patient with lung cancer.

1 9 24

Reposted by Sarah Gorey

NEJM.org @nejm.org · Apr 22

Our partnership with @glaucomflecken.bsky.social continues as he summarizes new research into fracture prevention with infrequent zoledronate in women 50 to 60 years of age. Access the article for free: nej.md/DrG15

#MedSky

11 27

Reposted by Sarah Gorey

NEJM.org @nejm.org · Apr 22

A 56-year-old man was transferred to a burn center for management of pavement burns on his feet that had occurred during a heat wave. Read the full case details: nej.md/3Rh2XfR

@uwsph.bsky.social #MedSky #ClimateChange

Images in Clinical Medicine
Climate Change
Pavement Burns

Photo of burns on the patient's feet

1 2 13

Reposted by Sarah Gorey

Chris Kotanidis @cpkotanidis.bsky.social · Apr 22

New research alert: Our latest report highlights a significant reduction in coronary #inflammation and residual inflammatory risk as captured by #CCTA imaging using CaRi-Heart AI in women with #BreastCancer 2 years post-RT
#AI #CardioOncology #CardioEd #EHJ
@escardio.bsky.social

Coronary inflammation and cardiovascular risk in breast cancer after radiotherapy

Radiotherapy (RT) is known to reduce the rate of disease recurrence following breast-conserving surgery in patients with breast cancer, but also entails ir

academic.oup.com

3 2

Reposted by Sarah Gorey

CORE IM @coreimpodcast.bsky.social · Apr 16

1/ 🚨 NEW #BeyondJournalClub w/ @NEJMGroup: PURPOSE Trials

Both PURPOSE 1 & 2 used a new long acting medication: Lenacapavir!

Let’s learn what we can takeaway from these trials ⤵️

🖥️: coreimpodcast.com/2025/04/16/a-r…

1 2 4

Reposted by Sarah Gorey

Shreya P. Trivedi MD, MHPE @shreyatrivedimd.bsky.social · Apr 2

An outstanding episode - learned a ton 🥂

CORE IM @coreimpodcast.bsky.social · Apr 2

1/ 🚨 NEW #5Pearls: Lp(a) and ASCVD Risk

Lp(a) is a lipoprotein similar to LDL but a different entity!

Lp(a) has important implications for cardiovascular disease ‼️

🖥️: coreimpodcast.com/2025/04/02/lpa…
Sponsor: Freed AI

2 2

Reposted by Sarah Gorey

NEJM.org @nejm.org · Mar 29

Editorial: Cancer-Associated Venous Thromboembolism — Beyond 6 Months nej.md/4iB6wcA

1 4

Reposted by Sarah Gorey

Chris Kotanidis @cpkotanidis.bsky.social · Mar 26

Ever wondered how interim analyses work in #RCTs? 📊 Check out our Stats, STAT! video at NEJM Evidence: @nejm.org @ai.nejm.org @sarahgorey.bsky.social evidence.nejm.org/doi/full/10.... #MedStats #ClinicalTrials

How Interim Analyses Work

This Stats, STAT! animated video explores interim analyses in clinical trials. During these evaluations of the data, researchers may assess safety, efficacy, and verify sample size assumptions, but...

evidence.nejm.org

1 3 3

Reposted by Sarah Gorey

NEJM.org @nejm.org · Mar 18

What is the impact of microplastics on human health? The latest episode of Beyond Journal Club, a collaboration between @coreimpodcast.bsky.social and NEJM Group, takes a deep dive into the APAChE study on microplastics and cardiovascular disease. 🎧 Listen here: nej.md/4igpJQy

#MedSky

An illustration of the APAChE study results

2 12 26

Reposted by Sarah Gorey

NEJM.org @nejm.org · Mar 14

The SCALE Kids trial, summarized here by NEJM Editorial Fellow Harleen Marwah, MD, assessed the efficacy and safety of liraglutide, as compared with placebo, as an adjunct treatment to lifestyle interventions, for the treatment of obesity in children 6 to 12 years of age. Full trial: nej.md/3MBP1uc

2 4 6

Sarah Gorey @sarahgorey.bsky.social · Mar 5

A great listen from the coreIM team on potential health effects of microplastics and a nuanced discussion on causality and limitations of observational studies ❤️👏🐥

CORE IM @coreimpodcast.bsky.social · Mar 5

1/ 🚨 NEW #BeyondJournalClub w/ @NEJMGroup: The APACHE Study ⤵️

We gave a sneak peak the other day, but now let’s dive into it 🌊

🖥️: coreimpodcast.com/2025/03/05/mic…

2 4

Reposted by Sarah Gorey

Irish Doctors for the Environment @irishdocsenv.bsky.social · Feb 25

A truly beautiful piece by Dr Lisa McNamee (@lisadangermcnamee.bsky.social)!

Everyone should read this!

Turning despair into action - Medical Independent

In January, climate action advocate and Dundalk GP Dr Seán Owens was seriously injured while cycling home from work...

www.medicalindependent.ie

1 9 29

Reposted by Sarah Gorey

The Lancet @thelancet.com · Feb 25

"By staying true to its mission and embracing necessary reforms, PEPFAR can...continue to be a beacon of hope in the fight against HIV/AIDS."

Comment—PEPFAR under review: what's at stake for PEPFAR's future tinyurl.com/28ahdmv8 #MedSky

PEPFAR under review: what's at stake for PEPFAR's future

The US President's Emergency Plan for AIDS Relief (PEPFAR) faces a pivotal moment, confronting one of its most challenging periods since its launch in 2003. The new policy priorities of the administra...

tinyurl.com

6 8