RASopathies Network
@rasnet.bsky.social
340 followers
580 following
190 posts
Nonprofit research advocacy org for conditions caused by dysfunctional RAS/MAPK signaling. #rasopathies #raredisease
by Stronach in Pittsburgh
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A high-fidelity protocol for #hiPSC-derived Fibrosa vs Spongiosa #ValvularIntersistialCell
Endocardial state +FGF2/BMP4/TGFB2➡️
Fibrosa subset: PRRX2 TIMP3 ITGA2 (most discriminative marker)
Endocardial state +FGF2➡️
Spongiosa subset: LUM APOE
bioRxiv 2025
www.biorxiv.org/content/10.1...
Endocardial state +FGF2/BMP4/TGFB2➡️
Fibrosa subset: PRRX2 TIMP3 ITGA2 (most discriminative marker)
Endocardial state +FGF2➡️
Spongiosa subset: LUM APOE
bioRxiv 2025
www.biorxiv.org/content/10.1...
Reposted by RASopathies Network
A high-fidelity protocol for #hiPSC-derived Fibrosa vs Spongiosa #ValvularIntersistialCell
Endocardial state +FGF2/BMP4/TGFB2➡️
Fibrosa subset: PRRX2 TIMP3 ITGA2 (most discriminative marker)
Endocardial state +FGF2➡️
Spongiosa subset: LUM APOE
bioRxiv 2025
www.biorxiv.org/content/10.1...
Endocardial state +FGF2/BMP4/TGFB2➡️
Fibrosa subset: PRRX2 TIMP3 ITGA2 (most discriminative marker)
Endocardial state +FGF2➡️
Spongiosa subset: LUM APOE
bioRxiv 2025
www.biorxiv.org/content/10.1...
Reposted by RASopathies Network
Reposted by RASopathies Network
my latest investigation for @consumerreports.org is based on months of reporting and 60+ lab tests of leading protein supplements
we found that most protein powders and shakes have more lead in one serving than our experts say is safe to have in a day (🧵)
www.consumerreports.org/lead/protein...
we found that most protein powders and shakes have more lead in one serving than our experts say is safe to have in a day (🧵)
www.consumerreports.org/lead/protein...
Protein Powders and Shakes Contain High Levels of Lead - Consumer Reports
CR tests of 23 popular protein powders and shakes found that most contain high levels of lead.
www.consumerreports.org
The Department of Energy has listed the Philadelphia and Pittsburgh area hydrogen hubs as projects targeted for termination. Together, they could lose $1.7 billion dollars in federal funding.
Trump administration could pull funding for Philadelphia, Pittsburgh hydrogen hubs
The Philly region’s MACH2 hydrogen hub promises to produce hydrogen fuel using renewable sources. The ARCH2, based in western Pennsylvania, would use fossil fuels.
buff.ly
Reposted by RASopathies Network
Reposted by RASopathies Network
Reposted by RASopathies Network
Reposted by RASopathies Network
Study reveals perineurial hyperplasia, lipid-associated nerve macrophages in 33 PNP patients vs. 4 controls using 365,708 nuclei for deeper PNP insights. PMID:40849297, Nat Commun 2025, @NatureComms https://doi.org/10.1038/s41467-025-62964-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
Multi-omic identification of perineurial hyperplasia and lipid-associated nerve macrophages in human polyneuropathies | Nature Communications
Diseases affecting multiple peripheral nerves, termed polyneuropathies (PNPs), are common, mechanistically heterogeneous, and their causes are challenging to identify. Here, we integrated single-nucleus transcriptomics of peripheral nerves from 33 human PNP patients and four controls (365,708 nuclei) with subcellular spatial transcriptomics. We identified nerve cell type markers and uncovered unexpected heterogeneity of perineurial cells. PNPs shared a loss of myelinating and an increase in repair Schwann cells and endoneurial lipid-phagocytizing macrophages. Transcriptional changes affected multiple cells outside of the endoneurium across PNPs, suggesting PNPs as ‘pan-nerve diseases’. Spatially, PNPs—particularly those mediated by autoimmunity—exhibited focal perineurial hyperplasia and increased expression of CXCL14, identified as perineurial cell marker. Multi-omic characterization of human nerve biopsies thus identified novel mechanisms in PNPs with diagnostic potential. Polyneurop
doi.org
Reposted by RASopathies Network
Very saddened to hear of John Gurdon’s passing. I’ve been lucky enough to interact with him at multiple points through my career - from undergrad lectures, through his position as former Chair of @biologists.bsky.social’s Board of Directors, and as an author at @dev-journal.bsky.social.
Nobel Laureate Professor Sir John Gurdon dies aged 92
It is with great sadness that the University shares the news of the death of Professor Sir John Gurdon, founder of the Gurdon Institute.
www.cam.ac.uk
Reposted by RASopathies Network
Reposted by RASopathies Network
Reposted by RASopathies Network
Reposted by RASopathies Network
Reposted by RASopathies Network