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Pilhofer Lab 🦠❄️🔬

@pilhoferlab.bsky.social

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Pilhofer Lab 🦠❄️🔬 @pilhoferlab.bsky.social · Mar 21

Asgard archaea have actin - but what about microtubules? Where do they come from? 🧐 Our new paper www.cell.com/cell/fulltex... by @xujwet.bsky.social & @florianwollweber.bsky.social, in collaboration with the Schleper & Wieczorek labs, describes tiny Asgard microtubules! #TeamTomo #ArchaeaSky 1/6

Credit: Margot Riggi (@margotriggi.bsky.social), Max-Planck Institute of Biochemistry (@mpibiochem.bsky.social)

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Reposted by Pilhofer Lab 🦠❄️🔬

Wieczorek Lab @mike-wieczorek.bsky.social · 3d

Huge congratulations to Wieczorek Lab PhD student Bin Cai and now-PI Jingwei Xu @xujwet.bsky.social on figuring out the surprisingly complex structure of the A-C linker crosslinking microtubule triplets in Tetrahymena basal body centrioles! www.science.org/doi/10.1126/...

Structure and assembly of the A-C linker connecting microtubule triplets in centrioles

Multiscale cryo-EM of centrioles reveals the structure and polymorphism of the A-C linker connecting microtubule triplets.

www.science.org

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Reposted by Pilhofer Lab 🦠❄️🔬

Cascales Lab @cascaleslab.bsky.social · 4d

Open position to work on Type IX secretion (#T9SS) in our lab, in collaboration withe the group of Eric Reynolds at the Dental School of the University of Melbourne. Please spread the word, and forward to anyone potentially interested ! Apply here:
emploi.cnrs.fr/Offres/Docto...

Portail Emploi CNRS - Offre d'emploi - Thèse en Microbiologie-Biochimie (H/F)

emploi.cnrs.fr

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Reposted by Pilhofer Lab 🦠❄️🔬

Jörg Vogel @jorg-vogel-lab.bsky.social · 5d

Two group leader positions available in the broader areas of RNA science, RNA technologies, and RNA medicine. Attractive packages and a great environment. Come and join us at Helmholtz RNA Würzburg, Bavaria.

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Reposted by Pilhofer Lab 🦠❄️🔬

Milan Gerovac @gerovac.bsky.social · Sep 11

No Genetics? Try ASOs – A non-genetic approach to silence genes at the phage-host interface. We use it to study jumbo phage biology and anti-phage defence.
@jorg-vogel-lab.bsky.social @helmholtz-hiri.bsky.social
@uni-wuerzburg.de @helmholtzhzi.bsky.social
published now in @nature.com

Programmable antisense oligomers for phage functional genomics - Nature

Establishing antisense oligomers as versatile, non-genetic tools to silence phage mRNAs opens applications in basic research and biotechnology, as shown by identifying essential factors for propagatio...

www.nature.com

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Pilhofer Lab 🦠❄️🔬 @pilhoferlab.bsky.social · 5d

🧐Checkout our preprint revealing the stepwise firing💥 mechanism of a Contractile Injection System @xujwet.bsky.social [email protected] trapped the complex by structure-guided engineering🧪 in multiple intermediate states and imaged them by multimodal #cryoEM❄️🔬
www.biorxiv.org/content/10.1...

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Pilhofer Lab 🦠❄️🔬 @pilhoferlab.bsky.social · 5d

Congrats🥳 to @mike-wieczorek.bsky.social, Bin Cai, and our former lab member Jingwei Xu @xujwet.bsky.social to their multiscale imaging 🔬 story of the centriolar AC linker #teamtomo
www.science.org/doi/10.1126/...

Structure and assembly of the A-C linker connecting microtubule triplets in centrioles

Multiscale cryo-EM of centrioles reveals the structure and polymorphism of the A-C linker connecting microtubule triplets.

www.science.org

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Reposted by Pilhofer Lab 🦠❄️🔬

EMBO @embo.org · 6d

Learn all things #cytoskeleton #research in an interdisciplinary environment at EMBO Workshop "Structure and Function of the Cytoskeleton" in Paris, FR, 7–10 April 2026.

Deadline: 20 December 2025

https://meetings.embo.org/event/26-cytoskeleton
#EMBOCytoskeletalFunction #EMBOevents #conference 🧪

Structure and Function of the Cytoskeleton

The cytoskeleton, a dynamic and intricate network of protein filaments, is found within the cytoplasm of all cells, from bacteria and archaea to complex eukaryotes. This essential cellular component …

meetings.embo.org

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Reposted by Pilhofer Lab 🦠❄️🔬

The Daum Lab @daumlab.bsky.social · 8d

Out in Science Advances: Our #cryoEM structure of HFTV1, a virus infecting the halophile #archaea. *First full atomic structure (containing all structural proteins) of any tailed virus!* Congrats and thanks to all co-authors and our fantastic collaborators! www.science.org/doi/10.1126/...

Cryo-EM resolves the structure of the archaeal dsDNA virus HFTV1 from head to tail

This structure of an archaeal tailed virus (arTV) provides detailed insights into arTV assembly and infection mechanisms.

www.science.org

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Reposted by Pilhofer Lab 🦠❄️🔬

qiangguo.bsky.social @qiangguo.bsky.social · 9d

What's the role of stress granules in translation? Here we provide a clue: we characterized the distribution of ribosomal complexes within SGs and reproduced this landscape with a phase-field model, pointing to a new regulatory mechanism. #TEAMTOMO www.science.org/doi/10.1126/...

Translation landscape of stress granules

Cryo–electron tomography visualizes stress granules in situ, revealing their spatial interplay with translation machinery.

www.science.org

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Reposted by Pilhofer Lab 🦠❄️🔬

Erin Green @erinrgreen.bsky.social · 9d

Job alert ‼️ UChicago Micro is hiring! Open to tenured/tenure track faculty at all levels in any area of microbiology. Come join our amazing and growing department. apply.interfolio.com/174404

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Reposted by Pilhofer Lab 🦠❄️🔬

cryoEM papers @cryoempapers.bsky.social · 25d

Correlative MS Imaging for cellular identification and analysis of in situ cryo-ET www.biorxiv.org/content/10.1101/2025.09.16.676641v1 #cryoem

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Reposted by Pilhofer Lab 🦠❄️🔬

Cameron Thrash @jcamthrash.bsky.social · 11d

A new paradigm for outer membrane protein biogenesis in the Bacteroidota www.nature.com/articles/s41... #jcampubs

A new paradigm for outer membrane protein biogenesis in the Bacteroidota - Nature

Structural and biochemical studies of the β-barrel-assembly machinery from Flavobacterium johnsoniae reveal a subunit composition and assembly that are distinct from those of the canonical Escherichia coli complex.

www.nature.com

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Reposted by Pilhofer Lab 🦠❄️🔬

Ben Engel @cellarchlab.com · 14d

EXCITING NEWS!! We're searching for a new professor colleague at the Biozentrum🇨🇭. Ideal candidates are exploring novel biological questions with structure, biophysics, or high-resolution imaging. 🧪 🧶🧬 🔬

The call closes Nov 3. Please get in touch if you would like more information. Come join us! 👩‍🔬🤓

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Reposted by Pilhofer Lab 🦠❄️🔬

Samara Reck-Peterson @samreckpeterson.bsky.social · 14d

We are hiring an Assistant Professor of Biochemistry and Biophysics at Weill Cornell Medicine. Come join our collaborative research environment with state-of-the-art facilities in NYC! Application review starts Oct 22.
biochem.weill.cornell.edu/join-our-fac...

Join our Faculty | Department of Biochemistry & Biophysics

Call for applications:We invite applications for a tenure-track Assistant Professor position in the newly established Department of Biochemistry and Biophysics. We are conducting an open search for ou...

biochem.weill.cornell.edu

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Biozentrum, University of Basel @biozentrum.unibas.ch · 14d

Assistant/Associate Professor in Structural Biology, Biophysics or Biological Imaging

www.biozentrum.unibas.ch/open-positio...

#biozentrum #University #Basel #Professor #Structural #Biology #Biophysics #Biological #Imaging

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Géraldine Laloux @lalouxlab.bsky.social · 19d

📝New preprint! #MicroSky

🕰️We chart the full, synchronized lifecycle of a predatory bacterium using Hi-C, RNA-seq, ChIP-seq & microscopy.

🧬We uncover dramatic shifts in nucleoid architecture & transcription, tightly coordinated with predation.

www.biorxiv.org/content/10.1...

Dynamics and interplay of gene expression and chromosome organization across a predatory lifecycle

The obligate predatory bacterium Bdellovibrio bacteriovorus alternates between a motile attack phase and a growth phase inside another bacterium, during which it undergoes multiple rounds of DNA repli...

www.biorxiv.org

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Pilhofer Lab 🦠❄️🔬 @pilhoferlab.bsky.social · 19d

Huuge congrats 🥳🍸 to our friends, collaborators and former colleagues in the Matos Lab
www.maxperutzlabs.ac.at/news/latest-...

Max Perutz Labs Vienna @maxperutzlabs.ac.at · 19d

Paper alert! 📢 How do cells strike the perfect balance during meiosis? ⚖️ A new study from the Matos lab in @natureportfolio.nature.com uncovers how Holliday junctions and the synaptonemal complex safeguard crossovers ➡️ tinyurl.com/2k4mmpzu

@univie.ac.at
@meduniwien.ac.at

Reposted by Pilhofer Lab 🦠❄️🔬

Guenter Resch @nexperion.net · 21d

Happy to announce "Technical Innovations Using #SerialEM: A Community Meeting", a new format of hybrid meeting David Mastronarde and I are organizing in April 2026. For more info, a preliminary list of speakers, pre-registration etc. visit
www.nexperion.net/semcm2026

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Reposted by Pilhofer Lab 🦠❄️🔬

Enninga Lab @enningalab.bsky.social · 25d

🦠 Mycobacteria aren't just tough, they're interior designers! 🦠 Check out our latest #preprint 🚨, led by our PhD student @camimille.bsky.social , where we show that #Mycobacterium tuberculosis builds secret cytoplasmic membranes to adapt its metabolism and sneak past immunity 🤫

Thread coming soon!

bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 26d

Nitrate-responsive Mycobacterial Intracytoplasmic Membranes dampen Inflammation during Mycobacterium tuberculosis Infection https://www.biorxiv.org/content/10.1101/2025.09.17.676823v1

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Reposted by Pilhofer Lab 🦠❄️🔬

Ben Engel @cellarchlab.com · 21d

Huntingtin protein bound to actin filaments. I didn’t know it could do that! Nice one @schurlab.bsky.social and friends! 🧪🧶🧬 #TeamTomo

Institute of Science and Technology Austria (ISTA) @istaresearch.bsky.social · 21d

Cryo-ET visualization of HTT bound to F-actin, highlighted in the yellow square on the left.
On the right, a detailed zoom-in view of the molecular model of the HTT/F-actin complex is shown.

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Reposted by Pilhofer Lab 🦠❄️🔬

Misha Kudryashev @mishakudryashev.bsky.social · 21d

We have a preprint of a book chapter for you: Structural Analysis of Membrane Proteins in Cell-Derived Microvesicles.

We describe how to image membrane proteins in mid-sized vesicles using cryo-electron tomography

zenodo.org/records/1717...

Structural Analysis of Membrane Proteins in Cell-Derived Microvesicles

zenodo.org

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Reposted by Pilhofer Lab 🦠❄️🔬

Ben Engel @cellarchlab.com · 23d

A molecular-resolution look into the near-native architecture of the spinach chloroplast🌱. This one was a long time in the oven, but we're happy to finally share our "version of record". What long-standing debates did we settle? Check back for a short thread🧵 on Monday. #TeamTomo #PlantScience 🧪🧶🧬🔬🌾

eLife @elife.bsky.social · 23d

🌱 Using ‘compelling’ methods, including #CryoET, researchers mapped spinach thylakoid membranes at single-molecule precision, revealing how photosynthetic complexes are organised and settling long-standing debates on chloroplast architecture.
buff.ly/j3TSIkn