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NEJM.org @nejm.org · 3m

In a trial involving participants with systemic lupus erythematosus, the incidence of a clinical response was higher with telitacicept than with placebo, although infections and reduced immunoglobulin levels were more common. Full 18C010 phase 3 trial results: nej.md/42EmA7I

#MedSky #Rheumatology

A graph showing the response on the modified SRI-4 over time (full analysis population).

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NEJM.org @nejm.org · 33m

Editorial: Sentinel Lymphadenectomy for Early-Stage Cervical Cancer — the New Standard? nej.md/3KNhQXe

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NEJM.org @nejm.org · 33m

In early-stage cervical cancer, sentinel-lymph-node biopsy alone was noninferior to lymphadenectomy with respect to disease-free survival and reduced surgical complications such as lymphedema, pain, and paresthesia. Full PHENIX phase 3 trial: nej.md/4oaZled

#MedSky #Oncology

Original Article | Oct. 16, 2025
Sentinel-Lymph-Node Biopsy Alone or with Lymphadenectomy in Cervical Cancer (PHENIX)
Figure 1A. Disease-free Survival

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NEJM.org @nejm.org · 2h

BaxHTN phase 3 trial: Aldosterone dysregulation is considered a key driver of hard-to-control hypertension. Research findings on baxdrostat, a highly selective, potent aldosterone synthase inhibitor, in hard-to-control hypertension are summarized in a new Quick Take video. nej.md/3KCsQGJ

A visual representation of the BaxHTN phase 3 trial, which evaluated baxdrostat, a highly selective, potent aldosterone synthase inhibitor, in patients with hard-to-control hypertension.

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NEJM.org @nejm.org · 5h

Review Article by Jonathan C. Horton, MD, PhD: Idiopathic Intracranial Hypertension nej.md/3KJlVvk

#MedSky #NeuroSky #Ophthalmology

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Reposted by NEJM.org

NEJM AI @ai.nejm.org · 8h

In the latest episode of the NEJM AI Grand Rounds podcast, Dr. Jonathan Chen discusses his path from teenage programmer to Stanford physician-informatician and why machine learning has both thrilled and unnerved him. Listen to the full episode: nejm.ai/ep35

#AI #MedSky

AI GRAND ROUNDS

EPISODE 35
Medicine, Machines, and Magic: Dr. Jonathan Chen on Medical AI

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NEJM.org @nejm.org · 8h

In a double-blind, randomized, placebo-controlled trial conducted in Uganda, the use of permethrin-treated baby wraps significantly reduced the incidence of clinical malaria among young children. Full trial results and Research Summary: nej.md/4msFwwX

#MedSky #PedSky #IDSky

The New England Journal of Medicine
Permethrin-Treated Baby Wraps for the Prevention of Malaria
A Research Summary based on Boyce RM et al. | 10.1056/NEJMoa2501628 | Published on September 24, 2025

Visual representations of the patients in the trial and the treatments they were assigned.

Read the full Research Summary at NEJM.org.

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NEJM.org @nejm.org · 9h

Decisions about critical care are almost always made without access to genetic information. Wojcik and colleagues report the application of a new method of DNA sequencing in infants in a neonatal intensive care unit. Read more: nej.md/4qg4KlE

#ASHG25 | @geneticssociety.bsky.social

Stacked bars indicating the durations of the laboratory, Xpandomer synthesis, sequencing and primary-analysis steps, and secondary-analysis steps, with the start time normalized to hour 0.

Radial plot bars indicating the wall-clock timing for each of the prospective cases, including transport time, laboratory processing and sequencing, and time for tertiary analysis and report generation.

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NEJM.org @nejm.org · 1d

A 22-year-old woman presented with a 3-month history of bumps on the right ventral surface of her tongue. On physical examination, the bumps were observed to be pink papillomatous lesions measuring 3 to 8 mm in diameter. Read the full case details: nej.md/4mH8U2I

#MedSky #DermSky

Images in Clinical Medicine
Oral Verruciform Xanthomas

Panel A: A photo of the pink papillomatous lesions measuring 3 to 8 mm in diameter.
Panel B and inset: Histopathological analysis of an excised lesion revealing acanthotic, papillary, and parakeratinized epithelium with an accumulation of large cells with foamy cytoplasm in the connective tissue.

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NEJM.org @nejm.org · 1d

𝘈𝘦𝘥𝘦𝘴 𝘢𝘦𝘨𝘺𝘱𝘵𝘪 mosquitoes spread chikungunya, dengue, and Zika. In a trial in Mexico, targeted indoor residual spraying led to lower mosquito levels but not lower disease risk. Full trial results and Research Summary: nej.md/46J4e7O

#MedSky #IDSky

The New England Journal of Medicine
Targeted Indoor Spraying to Prevent Aedes-Borne Diseases
A Research Summary based on Dean NE et al. | 10.1056/NEJMoa2501069 | Published on October 9, 2025

Visual representations of the patients in the trial and the treatments they were assigned.

Read the full Research Summary at NEJM.org.

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NEJM.org @nejm.org · 2d

An AI system and a physician were given a case presentation describing a patient who was admitted to the hospital because of fever, hypoxemia, and bacteremia. Their differential diagnoses are shown in videos of slide-based presentations. Learn more: nej.md/3KYBaAE

#MedSky

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NEJM.org @nejm.org · 2d

A new review explores current ideas about the disease, with emphasis on the importance of dural venous sinus stenosis and new treatment options. Read the full review: nej.md/3KJlVvk

#MedSky #NeuroSky #Ophthalmology

Key points from the Review Article "Idiopathic Intracranial Hypertension"

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NEJM.org @nejm.org · 2d

In the BaxHTN phase 3 trial involving patients with uncontrolled or resistant hypertension, baxdrostat added to background therapy led to a lower seated systolic blood pressure than placebo at 12 weeks. Full trial results and Research Summary: nej.md/4my7xUZ

#MedSky #CardioSky

The New England Journal of Medicine
Efficacy and Safety of Baxdrostat in Uncontrolled and Resistant Hypertension
A Research Summary based on Flack JM et al. | DOI: 10.1056/NEJMoa2507109 | Published on August 30, 2025

Visual representations of the patients in the trial and the treatments they were assigned.

Read the full Research Summary at NEJM.org.

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NEJM.org @nejm.org · 3d

In a 21-year-old woman who presented with a 7-day history of sore throat and cough, a chest radiograph showed two hemivertebrae at the ninth thoracic vertebral body. Read the full case details: nej.md/4pZCCCR

#MedSky #Orthopedics #Radiology

Panel A: A chest radiograph showing normal lungs and two hemivertebrae at the ninth thoracic vertebral body (T9).
Panels B–D: Subsequent computed tomography of the chest showing a sagittal cleft (axial view), anterior wedging (parasagittal view), and symmetric, triangular hemivertebrae resembling the wings of a butterfly at T9 (coronal view).

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NEJM.org @nejm.org · 3d

Presented at #OTOMTG25:

Valayannopoulos and colleagues report the outcomes of treating 12 participants who had complete inherited deafness with gene therapy. Full CHORD phase 1–2 study results: nej.md/4o7ky8f  

#MedSky #Otolaryngology

AAO-HNSF 2025 Annual Meeting & OTO EXPO

Original Article | OCT 12, 2025 | NEJM.org
DB-OTO Gene Therapy for Inherited Deafness

Figure 3. Auditory Brain-Stem Response at Week 24.

NEJM identity sits at the bottom.

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NEJM.org @nejm.org · 4d

Malaria remains a major cause of childhood death in sub-Saharan Africa. Treating the cloth wraps mothers traditionally use to carry their babies may provide additional protection. Research findings are summarized in a new Quick Take video. nej.md/430nBXE

#MedSky #IDSky

A visual representation of a trial in western Uganda that assessed whether treating the cloth wraps mothers use to carry young children might provide additional protection against malaria.

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NEJM.org @nejm.org · 4d

NEJM National Correspondent Lisa Rosenbaum, MD, shares a preview of season 3 of the “Not Otherwise Specified” podcast premiering October 15.

Listen to past episodes and subscribe to the podcast: nej.md/NOS

#MedSky

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NEJM.org @nejm.org · 4d

2️⃣ Surveillance of Health Care–Associated Infections nej.md/4h0xmuG

3️⃣ The AI Frontier in Humanitarian Aid nej.md/4pYmOR3

Subscribe to NEJM for the latest medical research: nej.md/subscribe

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NEJM.org @nejm.org · 4d

Weekend Briefing for October 11, 2025:

New Images in Clinical Medicine: Pneumococcal Sepsis in Asplenia and Hypogammaglobulinemia nej.md/4oap9GL

Three New Perspectives:

1️⃣ Digital Treatment to Reduce Global Tobacco Use nej.md/4nKq29e

#MedSky

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NEJM.org @nejm.org · 5d

Physical examination was notable for abdominal distention and mild tenderness to palpation on the left side of the abdomen. Computed tomography of the abdomen and pelvis is shown. What is the most likely diagnosis? nej.md/IC10092025 2/2

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NEJM.org @nejm.org · 5d

A 23-year-old man with autism spectrum disorder and chronic constipation presented to the emergency department with a 1-week history of abdominal pain on his left side, nausea, and vomiting. 1/2

#MedSky

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NEJM.org @nejm.org · 5d

To learn more about this term, read the editorial “Defanging the Neutrophil to Treat Bronchiectasis”: nej.md/4cANv89

Explore more terms: nej.md/glossary

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NEJM.org @nejm.org · 5d

𝐑𝐞𝐚𝐜𝐭𝐢𝐯𝐞 𝐨𝐱𝐲𝐠𝐞𝐧 𝐬𝐩𝐞𝐜𝐢𝐞𝐬 are hydroxyl radicals, produced by the metabolism of oxygen, that are extremely reactive and immediately remove electrons from any molecule with which they interact. Full definition of this NEJM Illustrated Glossary term: nej.md/48UCLRX

#MedSky #ScienceSky

A visual representation of “reactive oxygen species”

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NEJM.org @nejm.org · 5d

As more patients with sickle cell disease or β-thalassemia are treated with the gene-edited cellular drug exa-cel, there are more opportunities to test for potential off-target editing. Yen and colleagues provide an update. Read now: nej.md/4ocjWy9

#MedSky #Hematology #Genetics

A diagram of the assessment of off-target editing in clinical trial participants.

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NEJM.org @nejm.org · 6d

As aedes-borne diseases surge in the Americas, new control approaches are needed against the primary mosquito vector, 𝘈𝘦𝘥𝘦𝘴 𝘢𝘦𝘨𝘺𝘱𝘵𝘪. Research findings on the efficacy of targeted indoor residual spraying are summarized in a new Quick Take video. nej.md/47e9S1V

#MedSky #IDSky

Visual representation of a study that examines the effectiveness of targeted indoor residual spraying of an insecticide to reduce the incidence of aedes-borne diseases in children.

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