Author | Lightnews

Chris Lupton @luptoncj.bsky.social · Aug 6

Very well deserved! A great reward for a a lot of hard work 😊

Charles Bayly-Jones @charlesbj.bsky.social · Aug 5

Earlier this year, I was incredibly honoured to receive the Premier’s Award for Health and Medical Research in the Basic Science category.

This recognition is a huge testament to the amazing work of our entire team. 🙌💥🎉

Photography and video: @vicgovau.bsky.social

www.youtube.com/watch?v=9_Ht...

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Reposted by Chris Lupton

Mike Martynowycz @sciencemick.bsky.social · Jul 5

Seed to sub-Å!
We just solved crambin at 0.85Å with #MicroED straight from spontaneous nanocrystals, phased ab-initio from a 5-res helix. Video shows diffraction ➜ ugly start map ➜ beautiful spheres. Preprint: www.biorxiv.org/content/10.1...
#StructuralBiology #CryoEM

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Chris Lupton @luptoncj.bsky.social · Feb 11

Awesome talk from @bradleyspicer.bsky.social telling us all about his work on insecticidal proteins. Very cool stuff! #lorneproteins2025

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Reposted by Chris Lupton

Bradley Spicer @bradleyspicer.bsky.social · Jan 16

🚨 Save the Date! 🚨

I'm thrilled to announce the Prato Conference on Pore Forming Proteins, happening this June in the stunning city of Prato, Italy!

🙏 Please share or repost this to help us reach as many people as possible—especially those who would love to attend!

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Reposted by Chris Lupton

Chen Davidovich @davidovichlab.bsky.social · Jan 16

We used cryoET and biophysical approaches in vitro together with molecular biology in differentiated cells to show that chromatin compacted by PRC1-CBX8 is porous and accessible while PRC1 is dynamic in it. 🧪🧬 #cryoET #Epigenetics #Polycomb www.nature.com/articles/s41...

Dynamic PRC1–CBX8 stabilizes a porous structure of chromatin condensates - Nature Structural & Molecular Biology

Here the authors show that a gene-inactivating protein complex packs inactive genes into a dynamic and accessible structure. The study challenges the traditional views that restricted accessibility an...

www.nature.com

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Reposted by Chris Lupton

Evan Healy @evhealy.bsky.social · Jan 14

🧵 1/ We’re excited to share that our new paper with @adrianbracken.bsky.social lab is out 🎉 In this study (which began over 10 years ago!), we explore the biology of PRC2 and PRC1 in non-dividing cells. We also explore the effects of PRC2 inhibitor drugs on these cells. Here’s what we found👇

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Chris Lupton @luptoncj.bsky.social · Dec 12

Agreed. I've had presenters/audience from the poster next to me stand in front of my poster. Not ideal...

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Chris Lupton @luptoncj.bsky.social · Dec 7

Very cool! 😁

Charles Bayly-Jones @charlesbj.bsky.social · Dec 7

The PDBs for our TSC structure are now available!

To put the size of TSC in perspective, here's a ribosome... this thing is enormous. 🤩

#cryoEM #mTORC1 #TSC

rcsb.org/3d-view/9CE3
science.org/doi/10.1126/sciadv.adr5807
@luptoncj.bsky.social

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Chris Lupton @luptoncj.bsky.social · Nov 21

Great to see our work on the #cryoem structure of the human TSC:WIPI3 lysosomal recruitment complex! Awesome effort from co-authors @charlesbj.bsky.social and Laura D'Andrea with @drellisdon.bsky.social doing the heavy lifting leading the project.

www.science.org/doi/10.1126/...

Structure of the human TSC:WIPI3 lysosomal recruitment complex

The complete TSC structure reveals how lysosomal targeting proteins and phosphoinositides coordinate mTORC1 inhibition.

www.science.org

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Reposted by Chris Lupton

Andrew Ellisdon @drellisdon.bsky.social · Nov 20

Our latest study is now online at Science Advances! We report the structure of the gigantic TSC:WIPI3 complex revealing new insights into lysosomal docking and dysregulation in disease. #cryoEM #mTOR 🧪

www.science.org/doi/10.1126/...

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Reposted by Chris Lupton

Andrew Ellisdon @drellisdon.bsky.social · Oct 9

Excited to see our latest study published!

We report several structures of the intriguing LYCHOS (GPR155) protein revealing a chimeric structure of a GPCR and a PIN-like transporter domain #cryoEM #mTOR #GPCR #auxin

www.nature.com/articles/s41...

LYCHOS is a human hybrid of a plant-like PIN transporter and a GPCR - Nature

Cryo-electron microscopy structures of the human lysosomal transmembrane protein LYCHOS show that it comprises a transporter-like domain fused to a G-protein-coupled receptor, and that the transporter...

www.nature.com

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Charles Bayly-Jones @charlesbj.bsky.social · Nov 20

🚨 Our story on the TSC:WIPI3 lysosomal-recruitment complex is now live in Science Advances.

Equal-first co-authors @luptoncj.bsky.social & Laura D'Andrea. Work lead by @drellisdon.bsky.social. Funding from @deptofdefense.bsky.social & Australian Research Council.

www.science.org/doi/10.1126/...

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Reposted by Chris Lupton

Charles Bayly-Jones @charlesbj.bsky.social · Nov 14

Another really nice highlight of our recent work. Arun et al raise interesting points about membrane cross talk and next-steps for LYCHOS. www.cell.com/cell/abstrac...

Bound by the love for cholesterol: A transporter meets a GPCR

In a recent issue of Nature, Bayly-Jones et al. report the cryo-EM structures of a lysosomal cholesterol sensor, LYCHOS, also known as GPR155, which reveals a unique fusion of a plant auxin-transporte...

www.cell.com

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Chris Lupton @luptoncj.bsky.social · Nov 14

Thanks! It really was very cool and there's still so much more to discover!

Chris Lupton @luptoncj.bsky.social · Nov 14

Very cool to see our work on the #cryoEM structure of LYCHOS as the Editor's Choice in Science Signalling! Thanks @jffoley.bsky.social !!

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