Author | Lightnews

Kyle Perry

Kyle Perry

@kyledperrymd.bsky.social

47 followers 53 following 23 posts

Bone and soft tissue, surgical and cytopathologist at University of Michigan | @UMichPath@UMichMedicine | T/RT not medical advice

Posts Media Videos Starter Packs

Kyle Perry @kyledperrymd.bsky.social · Jul 27

Stomp Out Sarcoma Fun Run/Walk is tomorrow at 9 AM in Hudson Mills MetroPark, Dexter, Michigan, for anyone interested in a running event! Walk-up registration begins at 8 AM.

michiganmedicine.donordrive.com/events/729

Support Stomp Out Sarcoma 2025!

I registered for the Stomp Out Sarcoma Fun Run/Walk in support of the @UMRogelCancerCenter! You can help make my run a success by making a donation. Your contribution will support Sarcoma Clinical Res...

michiganmedicine.donordrive.com

Kyle Perry @kyledperrymd.bsky.social · May 6

Nice review article by Szczepanski, Westerhoff and Schechter on this rare entity (pubmed.ncbi.nlm.nih.gov/39743931/)

Kyle Perry @kyledperrymd.bsky.social · May 6

The spindled morphology and plexiform architecture can sometimes cause these tumors to be mistaken for (SDH-deficient) GIST. Unlike GIST, these tumors are negative for CD117 and DOG1.

Kyle Perry @kyledperrymd.bsky.social · May 6

It’s gastric and spindled, but it’s not a GIST… Plexiform fibromyxoma is a benign tumor that presents as a multinodular intramural mass in the stomach. The nodules can be fibrous or myxoid and have a delicate capillary pattern. #BSTPath, #UmichPath, #BSTpathGoBlue

Kyle Perry @kyledperrymd.bsky.social · Apr 13

Special thanks to my U of Michigan colleagues for allowing me to share this case!

Kyle Perry @kyledperrymd.bsky.social · Apr 13

Some nice papers (Fritchie and colleagues/ Chung and colleagues) further elaborating on this entity(ies)….
pubmed.ncbi.nlm.nih.gov/33097826/
pubmed.ncbi.nlm.nih.gov/33300192/

Kyle Perry @kyledperrymd.bsky.social · Apr 13

Fibromyxoid soft tissue tumors/fibroblastic lipoblastomas with a PLAG1 gene fusion often contain foci of myxoid stroma in the background of a more fibrous appearance. In addition to PLAG1 staining, these tumors usually show expression of desmin and CD34.

Kyle Perry @kyledperrymd.bsky.social · Apr 13

Dealing with an unusual fibromyxoid spindle cell neoplasm (that is MUC4 negative)? Consider PLAG1! #BSTPath, #UmichPath, #BSTpathGoBlue

Kyle Perry @kyledperrymd.bsky.social · Mar 31

I would highly recommend this course for anyone (regardless of level of expertise) looking for a comprehensive/case-based experience with bone and soft tissue. Dr. Fritchie and colleagues at Cleveland Clinic are excellent teachers.
www.clevelandclinicmeded.com/live/courses...

Kyle Perry @kyledperrymd.bsky.social · Mar 31

Nice article on ALK-positive histiocytosis of the breast: pubmed.ncbi.nlm.nih.gov/32826530/

Kyle Perry @kyledperrymd.bsky.social · Mar 31

The liberal use of ALK and histiocytic markers, with follow-up and molecular testing, can help ensure proper identification. These tumors, including the case presented here, often exhibit a KIF5B::ALK gene fusion.

Kyle Perry @kyledperrymd.bsky.social · Mar 31

Interestingly, the cells in this case also showed staining for OCT2, which has historically been associated with other histiocytic-type proliferations, such as Rosai-Dorfman disease, some Langerhans cell histiocytosis, and juvenile xanthogranulomas.

Kyle Perry @kyledperrymd.bsky.social · Mar 31

Unlike IMT, the tumor cells of interest are negative for SMA and positive for PU.1. The cells exhibit more wrinkled and irregular nuclei, which can help suggest histiocytic differentiation.

Kyle Perry @kyledperrymd.bsky.social · Mar 31

ALK-positive histiocytosis of the breast is a rare tumor that can mimic other inflammatory neoplasms or processes, such as inflammatory myofibroblastic tumor, cellular spindled histiocytic pseudotumor (among others). #BSTPath, #UmichPath, #BSTpathGoBlue

Kyle Perry @kyledperrymd.bsky.social · Mar 16

Nice article by Dermawan and colleagues on CD34-negative solitary fibrous tumors:
pubmed.ncbi.nlm.nih.gov/34152108/

Kyle Perry @kyledperrymd.bsky.social · Mar 16

Nice article by Dermawan and colleagues on CD34-negative solitary fibrous tumors:
pubmed.ncbi.nlm.nih.gov/34152108/

Kyle Perry @kyledperrymd.bsky.social · Mar 16

Although not typically associated with a “round cell sarcoma” differential, solitary fibrous tumor can sometimes mimic small round cell type sarcomas such as Ewing sarcoma. #BSTPath, #UmichPath, #BSTpathGoBlue

Kyle Perry @kyledperrymd.bsky.social · Mar 16

Nice article by Sciallis, Chen and Folpe describing this entity. pubmed.ncbi.nlm.nih.gov/22982900/

Kyle Perry @kyledperrymd.bsky.social · Mar 16

Cellular spindled histiocytic pseudotumor can sometimes be confused for inflammatory myofibroblastic tumor (or other spindled cell neoplasms). The spindled cells exhibit irregular grooved nuclei which suggest the tumor’s histiocytic nature. #BSTPath, #UmichPath, #BSTpathGoBlue

Kyle Perry @kyledperrymd.bsky.social · Feb 8

Nice article on variable morphologies in desmoid fibromatosis.
pubmed.ncbi.nlm.nih.gov/27124915/

Kyle Perry @kyledperrymd.bsky.social · Feb 8

Of note, familiarity with your lab’s beta catenin stain is important as this stain can have variable sensitivity/specificity for desmoid fibromatosis (this case was negative for nuclear staining). Sequencing for CTNNB1 can be helpful when the staining pattern is suspect.

Kyle Perry @kyledperrymd.bsky.social · Feb 8

While desmoid tumors are often deep seated, these can rarely present as more superficial/subcutaneous lesions. Areas of a more fascicular spindle cell arrangement or “perivascular edema” can help alert the pathologist to pursue additional studies.

Kyle Perry @kyledperrymd.bsky.social · Feb 8

Desmoid fibromatosis can sometimes exhibit histologic features which overlap with nodular fasciitis, including focal areas of a more haphazard spindle cell arrangement. #BSTpath, #UMichPath, #BSTpathGoBlue

Desmoid tumor with haphazard spindle cell arrangement.

Desmoid tumor with haphazard spindle cell arrangement.

Focal areas of more fascicular like architecture in desmoid tumor.

Focal vessel with perivascular edema.