José Aguilar-Rodríguez
@jaguilarrod.bsky.social
250 followers
640 following
57 posts
Evolutionary systems/cell biologist. EMBO and SNSF Postdoctoral Fellow with Dmitri Petrov and Dan Jarosz at Stanford. PhD with Andreas Wagner at the University of Zurich. Studying how molecular and cellular systems shape, and are shaped by, evolution.
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Reposted by José Aguilar-Rodríguez
Reposted by José Aguilar-Rodríguez
One of the most exciting works of my career, years in the making. We used high-throughput precision genome editing to test the fitness effects of thousands of natural variants. Our findings challenge the long-held assumption that common variants are inconsequential.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Massively parallel interrogation of the fitness of natural variants in ancient signaling pathways reveals pervasive local adaptation
The nature of standing genetic variation remains a central debate in population genetics, with differing perspectives on whether common variants are almost always neutral as suggested by neutral and n...
www.biorxiv.org
Reposted by José Aguilar-Rodríguez
One of the most exciting works of my career, years in the making. We used high-throughput precision genome editing to test the fitness effects of thousands of natural variants. Our findings challenge the long-held assumption that common variants are inconsequential.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Massively parallel interrogation of the fitness of natural variants in ancient signaling pathways reveals pervasive local adaptation
The nature of standing genetic variation remains a central debate in population genetics, with differing perspectives on whether common variants are almost always neutral as suggested by neutral and n...
www.biorxiv.org
Reposted by José Aguilar-Rodríguez
Reposted by José Aguilar-Rodríguez
Reposted by José Aguilar-Rodríguez
Reposted by José Aguilar-Rodríguez
Reposted by José Aguilar-Rodríguez
Shady Saad
@shadys11.bsky.social
· Apr 21
DNA binding and mitotic phosphorylation protect polyglutamine proteins from assembly formation
DNA binding and phosphorylation protect FOXP2, a transcription factor with the longest
polyQ track in the proteome, from aggregation during interphase and mitosis. Harnessing
these native solubility-p...
www.cell.com
Reposted by José Aguilar-Rodríguez
Reposted by José Aguilar-Rodríguez
Reposted by José Aguilar-Rodríguez
Reposted by José Aguilar-Rodríguez
One of the most exciting works of my career, years in the making. We used high-throughput precision genome editing to test the fitness effects of thousands of natural variants. Our findings challenge the long-held assumption that common variants are inconsequential.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Massively parallel interrogation of the fitness of natural variants in ancient signaling pathways reveals pervasive local adaptation
The nature of standing genetic variation remains a central debate in population genetics, with differing perspectives on whether common variants are almost always neutral as suggested by neutral and n...
www.biorxiv.org