Author | Lightnews

Reposted by Gregor Bond

Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 13h

Natural history of RRT from the ERA registry

The visual abstract in this case tells a lot

academic.oup.com/ndt/advance-...

@ndt-era.bsky.social #NephSky

Visual abstract
Sad story reflecting that most people start with HD and most of them die

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Gregor Bond @gregorbond.bsky.social · 7h

>50% hd to death 😥

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Reposted by Gregor Bond

Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 10d

Should we be screening every young child’s urine (as is done in some countries!)

@rheaultm.bsky.social and Oliver Gross make the case in @kireports.bsky.social

www.kireports.org/article/S246...

Main issue: we have therapeutic options!

#NephSky

Urine screening to early diagnose young individuals with CKD: a call for action

Alport syndrome is an inherited disorder of basement membranes leading to progressive chronic kidney disease, hearing loss, and ocular abnormalities in many affected patients. When the authors started...

www.kireports.org

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Gregor Bond @gregorbond.bsky.social · 11d

can viruses 🦠 be superheroes 🦸‍♂️ ?

PhD student Felix Herkner just published the statistical analysis plan
of the TTVguideIT trial 💪👏

Torque Teno virus guided immunosuppression #TTVguide

data cleaning until Q1/26
analysis Q2/26

trialsjournal.biomedcentral.com/articles/10....

Statistical analysis plan for TTVguideIT—a multicentre, patient- and assessor-blinded, non-inferiority, randomised and controlled phase II trial to compare standard and Torque Teno virus-guided immuno...

Background Non-interventional studies indicate an association between Torque Teno Virus (TTV) load in peripheral blood and immunosuppression related outcomes in kidney transplant recipients. This make...

trialsjournal.biomedcentral.com

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Reposted by Gregor Bond

Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 19d

As expected, Iptacopan phase 3 in IgA nephropathy slows GFR decline

APPLAUSE-IgA

Adding another new medication we won’t be able to access or afford to our IgA armamentarium

#NephSky

www.novartis.com/news/media-r...

Novartis Fabhalta® (iptacopan) meets Phase III primary endpoint, slows kidney function decline in patients with IgA nephropathy (IgAN)

www.novartis.com

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Reposted by Gregor Bond

Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 19d

Big win for telitacicept in SLE (not lupus nephritis, yet)

www.nejm.org/doi/full/10....

BAFF + APRIL FTW

#nephSky #Lupus

A Phase 3 Trial of Telitacicept for Systemic Lupus Erythematosus | NEJM

Telitacicept, a new dual inhibitor of the cytokines B-lymphocyte stimulator (BLyS) and APRIL (a proliferation-inducing ligand), showed efficacy in adults with active systemic lupus erythematosus (S...

www.nejm.org

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Gregor Bond @gregorbond.bsky.social · 18d

congrats to the poster price 🥳

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Gregor Bond @gregorbond.bsky.social · 18d

viruses 🦠 can be superheroes 🦸‍♀️

Felix Herkner present
the statistical analysis plan
of the TTVguideIT trial
at the Austrian Transplant Congress

Torque Teni Virus guided immunosuppression #TTVguide

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Gregor Bond @gregorbond.bsky.social · 24d

ah grad auf pubmed gefunden… und sie plant eine randomisiert kontrollierte studie zum thema apherese… find ich super… genau so eine studie fehlt

Gregor Bond @gregorbond.bsky.social · 24d

und wieso reicht sie nicht einfach einen antrag ein zur finanzierung ihrer wissenschaft bei drittmittelgebern, so wie alle anderen das machen, die auch forschung in der medizin machen und 0 oeffentlich gelder bekommen?

Gregor Bond @gregorbond.bsky.social · 24d

wo ist die studie zur „autoantikoerper entfernung“ publiziert?

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Gregor Bond @gregorbond.bsky.social · Sep 21

happy to speak about TT virus 🦠 @Italien 🇮🇹 micro biology congress

TTV based immune monotoring
#TTVguide

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Gregor Bond @gregorbond.bsky.social · Sep 2

mhm that makes me curiouse to have a look at the calculations of the DSMB that led to the termination of the trial; must have been a tought decision

Nephrology Journal Club @nephjc.bsky.social · Sep 1

Check out the ACHIEVE visual abstract by @nephromommy-akshu.bsky.social

www.nephjc.com/news/2025/8/...

The ACHIEVE visual abstract — NephJC

the use of spironolactone in patients on dialysis did not alter mortality or hospitalizations for heart failure. Similar results were seen in the simultaneously released ALCHEMY trial.

www.nephjc.com

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Gregor Bond @gregorbond.bsky.social · Sep 2

mhm that makes me curiouse to have a look at the calculations of the DSMB that led to the termination of the trial

Gregor Bond @gregorbond.bsky.social · Aug 31

well written; as a kidney doc I would just not agree that protein is bad for your kidneys

Eric Topol @erictopol.bsky.social · Aug 31

How much protein should you consume?
erictopol.substack.com/p/our-preocc...

Our Preoccupation With Protein Intake

The data on high protein diets, bars, supplements, and powders will surprise you

erictopol.substack.com

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Gregor Bond @gregorbond.bsky.social · Aug 25

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Gregor Bond @gregorbond.bsky.social · Aug 25

>7.000 kidney transplant recipients
on SGLT2 inhibitors & GLP-1RAs

▶️ better survival, cardiovascular & kidney outcomes, weight loss, lower HbA1c

no safety risks
tinyurl.com/4p6fdybn

SGLT2 Inhibitors and GLP-1 Receptor Agonists in Kidney... : Transplantation

ovascular and kidney benefits in non-KT recipients, but evidence in KT recipients remains limited. This systematic review and meta-analysis provide updated evidence on the efficacy and safety of SGLT2...

tinyurl.com

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Gregor Bond @gregorbond.bsky.social · Aug 9

I thought its india ink thats stains cryptococcus?

Reposted by Gregor Bond

Joel Topf @kidneyboy.bsky.social · Jul 25

I use a cool programmable calculator called Soulver that works on and syncs across my iPhone, iPad, and Mac.

I just created a formula to calculate the sodium after any combination of IV fluids and urine output based on Edelman.

sNa = 105 = 105
tbw = 50 = 50
=
D5W_In = 0 = 0
NS_In = 1000 = 1,000
LR_In = 0 = 0
Hypertonic_In = 200 = 200
tK_In = 40 = 40
Kwater_In = 400 = 400
urine_Na = 10 = 10
urine_K = 10 = 10
urine_Vol = 6000 = 6,000
=
final_Na = (eK_x_eNa + tNaIn + tK_In - urine_lytes)/(tbw + tWaterIn - urine_L) = 119.00438596
=
eK_x_eNa =sNa × tbw = 5,250
tNaIn = (NS_In × .154) + ( Hypertonic_In × 0.513) + (LR_In × 0.13) = 256.6
tWaterIn = (D5W_In + NS_In + Hypertonic_In + Kwater_In)/1000 = 1.6
urine_lytes = (urine_Na + urine_K) × urine_L = 120
urine_L = urine_Vol/1000 = 6
=
=
=
=
Total: 13568.2043859649

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Reposted by Gregor Bond

TTVguideTX @ttvguidetx.bsky.social · Jul 22

Last week, our team around @gregorbond.bsky.social from @meduniwien.ac.at took part in the "Kinderuni Wien" - Vienna’s Children’s University - to bring science to life for curious kids aged 7 to 12, where the kids learnt that some viruses like TTV can also be superheroes. #TTVguide

Gregor Bond @gregorbond.bsky.social · Jul 17

I had great fun at kids university @meduniwien.ac.at today 😁

viruses 🦠 can be superheroes 🦸‍♀️

🙏 @sebastiankaps.bsky.social
and @fredhaupenthal.bsky.social for your support

#ttvguide

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Gregor Bond @gregorbond.bsky.social · Jul 17

I had great fun at kids university @meduniwien.ac.at today 😁

viruses 🦠 can be superheroes 🦸‍♀️

🙏 @sebastiankaps.bsky.social
and @fredhaupenthal.bsky.social for your support

#ttvguide

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Reposted by Gregor Bond

TTVguideTX @ttvguidetx.bsky.social · Jul 2

Our team around @gregorbond.bsky.social recently participated at #ESOT2025 - here's our most important learnings: 🔸 More & more groups worldwide pick up the idea of TTV-guided immunosuppression. 🔸 First data on the association between TTV load & the development of malignomes is available. #ttvguide

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Gregor Bond @gregorbond.bsky.social · Jul 1

the highly prevalent and apathogenic TorqueTeno virus 🦠
is associated with immunosuppression 💊

Carsten Herz presents first data on the predicive value of malignancy post kidney transplant
#TTVguide

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Gregor Bond @gregorbond.bsky.social · Jun 30

#ESOTCongress London 🇬🇧
Action at the eposters

a multicenter observational study
to validate the value of proteinuria
for assessment of kidney graft quality

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