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Graham Wiley

@gbw42.bsky.social

300 followers 130 following 79 posts

A tall, sturdy creature fond of industry and DNA sequencing.

Posts Media Videos Starter Packs

Graham Wiley @gbw42.bsky.social · 16d

Claret Bio SRSLY

Graham Wiley @gbw42.bsky.social · 23d

I vibe coded today. I kinda liked it.

Graham Wiley @gbw42.bsky.social · Sep 1

Goodbye Summer 2025, it's been emotional.

youtu.be/lpIBsWM42PU?...

September Everywhere (Extended Mix)

YouTube video by Sultan Shepard - Topic

Graham Wiley @gbw42.bsky.social · Aug 7

10X Genomics acquiring Scale Biosciences.

Graham Wiley @gbw42.bsky.social · Jul 28

Vaya con dios, 3730.

Reposted by Graham Wiley

Manlio De Domenico @manlius.bsky.social · Jul 19

"our results indicate that academia pays a price by focusing attention and resources on superstars"

Nice to see this supported by data analysis, now.

H/T: @cxdig.bsky.social

www.nature.com/articles/s41...

The innovation trade-off: how following superstars shapes academic novelty - Humanities and Social Sciences Communications

Humanities and Social Sciences Communications - The innovation trade-off: how following superstars shapes academic novelty

Graham Wiley @gbw42.bsky.social · Jul 18

Found out the free drinks fountain at work can also output straight club soda. Couple that with some lemon wedges and I AM HYDRATED AF RIGHT NOW.

Graham Wiley @gbw42.bsky.social · Jul 4

Graham Wiley @gbw42.bsky.social · Jun 23

Illumina to acquire Somalogic.
www.illumina.com/company/news...

Illumina to acquire SomaLogic, accelerating its proteomics business and advancing the company's multiomics strategy

www.illumina.com

Graham Wiley @gbw42.bsky.social · Jun 3

Timeline: All updates coming Q3/Q4 this year, probably alongside the long-awaited 600-cycle 1.5B flowcells that Steve Barnard teased over a year ago. Hardware improvements finally catching up to promises.

Graham Wiley @gbw42.bsky.social · Jun 3

DRAGEN v4.4: Onboard analysis getting updated but unclear if it's full version like standalone servers or stripped-down instrument version. Details TBD - hoping someone in the know can clarify.

Graham Wiley @gbw42.bsky.social · Jun 3

Quality Improvements: Better Q-scores with less PhiX needed (1% new = 5% old). Likely algorithm tweaks reducing signal crosstalk. Means more robust sequencing for tricky low-complexity libraries plus overall quality gains.

Graham Wiley @gbw42.bsky.social · Jun 3

Index-First Sequencing: New feature lets you check pooling quality before full sequencing starts. Sounds useful but creates a dilemma - what if it looks bad? Can't reuse reagents once you've started, so may only help well-funded cores.

Graham Wiley @gbw42.bsky.social · Jun 3

Staggered Runs: NovaSeq X finally gets dual flowcell capability - no more 48hr waits while one side monopolizes the instrument. Game changer for high-throughput labs dealing with batching headaches when mixing different run types.

Graham Wiley @gbw42.bsky.social · Jun 3

As hardware stabilizes, it's time to start performance tweaking on the Illumina NovaSeq X. Here are some of the highlights from the latest batch of rumors regarding the next control software iteration:

Graham Wiley @gbw42.bsky.social · Jun 2

One of the best things in the world is a slice of ricotta cheesecake with a dollop of lemon curd. Or marmalade. Or both... Or just a dusting of powdered sugar. Some sliced strawberries. Maybe raspberries?

Anyway, the point is ricotta cheesecake is awesome. That's all.

Happy Monday!

Graham Wiley @gbw42.bsky.social · May 6

Tariffs hit the $ILMN supply chain.

Graham Wiley @gbw42.bsky.social · Apr 28

Right after having you round to the mothership?

Graham Wiley @gbw42.bsky.social · Apr 14

For all their faults they've got tech support down cold.

Graham Wiley @gbw42.bsky.social · Apr 4

Happy Friday, everyone.

Reposted by Graham Wiley

Eric Topol @erictopol.bsky.social · Apr 2

The vaccine against Shingles helps protect against dementia, results of a natural experiment, adding to prior evidence
"implications are profound"
New @nature.com
www.nature.com/articles/d41...
nature.com/articles/s41...

A natural experiment on the effect of herpes zoster vaccination on dementia - Nature

Using a natural experiment that avoids common bias concerns, this study finds that the live-attenuated shingles vaccine reduced the probability of a new dementia diagnosis within a follow-up period of...

Graham Wiley @gbw42.bsky.social · Apr 1

Wake up y'all, it's the 1st of tha month.

www.youtube.com/watch?v=4j_c...

Bone Thugs N Harmony - 1st of tha Month

YouTube video by Bone Thugs-N-Harmony

www.youtube.com

Reposted by Graham Wiley

Steven Hoffman @hoffmansteven.bsky.social · Apr 1

I am thrilled to be a part of this initiative to help keep science moving forward. If you have samples you can get them sequenced for free with Ultima Genomics: www.genengnews.com/topics/omics...

Ultima Genomics Gives Away Sequencing for Free. Literally.

Ultima Genomics announces that it will provide three trillion DNA sequencing reads free of charge to researchers across the United States and Canada.

www.genengnews.com

Graham Wiley @gbw42.bsky.social · Mar 20

a cartoon character from south park is sitting at a desk and says wow neato

ALT: a cartoon character from south park is sitting at a desk and says wow neato

media.tenor.com

Graham Wiley @gbw42.bsky.social · Mar 20

Right on, same here.