@fewill26.bsky.social
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Looking forward to having you back!
PhD defense day is always a great time to celebrate student accomplishments (awesome job Dr Cole Scholtz) and nab a new group pic!
Annual July 4th coffee sale with Linus. Almost go time!
Call for papers for a new special issue on covalent modulators. Consider submitting to ACS Med. Chem. Lett, J. Med. Chem. or ACS Chem. Biol.! pubs.acs.org/page/si/cova...
Exploring Covalent Modulators in Drug Discovery and Chemical Biology
pubs.acs.org
Got mine. Get 'em while they last
Bioorganic GRC is set! I got tired of the lack of swag so made a couple of unofficial tees. Order one if you want to support the conference (or simply enjoy strange looks in grocery stores).

Spirit: chembio-shop.fourthwall.com/products/grc...

World Tour: chembio-shop.fourthwall.com/products/spi...
Spirit
Preliminary score: ND
chembio-shop.fourthwall.com
Dont' forget to register for the 2025 Portoghese Lectureship Webinar on June 12th!
web.cvent.com/event/668f0f...
Reposted
Everyone in the past was neurotypical, which is how we got things like this single-author, eight-volume encyclopedia of ferns
eight leatherbound books all titled "FERNS" volumes 1 through 8
ACS MEDI degrader/induced proximity webinar about to start. Don't miss out!
This was a great collaboration with our UMN chemistry team and @mayoclinic.org collaborators, including Vijay Shah ad Harmeet Malhi @umnchemistry.bsky.social
And its finally out! Check out my recent article investigating the role of BRD4 in inflammation. But what excites me the most: we explore the safety side of things, and reduce the risk of BET side effects by >50 fold through more selective molecules.

pubs.acs.org/doi/10.1021/...

#chemsky
Efficacy and Toxicity Analysis of Selective BET Bromodomain Inhibitors in Models of Inflammatory Liver Disease
BET bromodomain inhibitors demonstrate significant promise as anti-inflammatory agents. However, clinical data demonstrated that nonselective BET bromodomain inhibitors led to significant dose-limitin...
pubs.acs.org
That is the way. Was fun!
Hey #chemsky , just saw February's NIH Advisory council was finally rescheduled for May 22. I found this very heartening news.
What are work retreats good for? Registering your first start up. Excited to take the plunge with Vijay Shah and Harmeet Malhi @mayoclinic.org for our LLC, BromoThera
BromoThera startup icon
I got an email from my SRO today that we are rescheduling our study section that was canceled last week and are now coordinating schedules. The earliest date allowed for us to meet is March 25.
Glad to see Hening is well integrated.
Depressing...
"PI's on five-year grants looking to extend their funding ..“That may be what is not going forward for review or for council,.. “So if you’re that PI, you’re going to have to start seriously thinking about laying off staff, because you won’t have the funds to pay them.”
After a month of prep work, just received the news that the my NIH study section is cancelled for tomorrow. My heart goes out to all of the PIs who are waiting on the news for their proposals. This is also very unsettling for NIH funding in general
Check out the newest virtual special issue at ACS Med Chem Lett and J. Med. Chem. highlighting the many faces of medicinal chemistry! pubs.acs.org/page/si/many... Editorial from Ashley Adams, Lori Ferrins, and Anna Junker @pubs.acs.org
Many Faces of Medicinal Chemistry
Published research on topics of current scientific interest.
pubs.acs.org
A thoughtful summary of what was glaringly absent from the recent NIH notice
Maybe the IDC model could be altered but not by a Friday night notice, but through a thoughtful data-driven discussion, versus cherry picked statements which don’t seem like they would hold up to peer review. Perhaps other scientists have thoughts.
Comparison to private foundations who have their own funding streams seems to be misguided. The comparison to prior statements saying what Universities would be willing to accept is also misguided, as that is done on an ad hoc basis and not for the entire funding portfolio.
The recent NIH IDC notice seems meant to be a stick in the eye of academic institutions. IDC’s are negotiated rates to do science covering both administrative burden (which has a capped rate) as well as the cost to keep the lights on and support our personnel.
For those of us who no longer get to enjoy the romance of being at the bench doing the science, the grant proposal is a critical necessity for being forced to do the deep thinking about the direction and implementation of our scientific ideas. Without this external pressure creativity will stagnate
For my 3-4 weeks of work, + 2 full 8 hour days of zoom review, I am reimbursed $400 by the federal government. That’s quite a bargain! A small perk, is I get to hang out with the brilliant minds across the country a couple times a year, which admittedly is a high point.