Eric Topol
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erictopol.bsky.social
Eric Topol
@erictopol.bsky.social

Eric Jeffrey Topol is an American cardiologist, scientist, and author. He is the founder and director of the Scripps Research Translational Institute, a professor of Molecular Medicine and Executive Vice-President at Scripps Research Institute, and a senior consultant at the Division of Cardiovascular Diseases at Scripps Clinic in La Jolla, California. .. more

Medicine 88%
Public Health 4%
Pinned
A new cover for SUPER AGERS after making the NYT bestseller list. Thanks to you for making it the #1 ranked new non-fiction book on Amazon.
amazon.com/gp/new-relea...

Not good to see the rise in p-tau181, a marker of brain inflammation tied to increased risk of Alzheimer's disease, in a prospective cohort (mean age 56 years) with #LongCovid and neurological symptoms

www.thelancet.com/journals/ebi...

Reposted by Joseph Thornton

A 5★ new review of the GLP-1 drugs, what they have achieved, and where the field is headed with so many new molecules and combinations
@thelancet.com

thelancet.com/journals/lan...

An excellent @nejm.org review of sudden cardiac death in athletes with what constitutes the appropriate workup, potential for returning to sports, and very good trend for survival over the years
nejm.org/doi/full/10....

Adds to a growing list and the movement to cures!
erictopol.substack.com/p/the-exhili...
The Exhilirating Movement From Treatment to Cures for Autoimmune Diseases
Exploiting Lessons from Cancer's Mirror Biology
erictopol.substack.com

Reposted by John De Vos

Another major triumph for a refractory autoimmune disease—hemolytic anemia—through engineered T cells
@nejm.org
nejm.org/doi/full/10....
CD19 CAR T-Cell Therapy for Autoimmune Hemolytic Anemia | NEJM
In patients with autoimmune hemolytic anemia (AIHA), the risk of relapse is high owing to persistent autoreactive B-cell activity. Multirefractory AIHA is a more advanced stage of disease that is d...
nejm.org

Exactly!

You can read the list of ingredients.
Recognize any of these in your kitchen?

Why do so many apparently healthy people die or get severely ill from infections that would be considered low risk?
For one, we don't have any way of assessing a person's immune system function in the clinic
nature.com/articles/d41...

Continuous glucose monitoring sensor data, with a foundation model, predicts risk of Type 2 diabetes and cardiovascular outcomes better than HbA1c
New @nature.com
www.nature.com/articles/s41...

Reposted by Karen O’Leary

Superior cf what? Full of ultraprocessed constituents.
The relentless and inappropriate marketing of David protein bars

Here's a roundup of facts about protein intake and unnecessary preoccupation erictopol.substack.com/p/our-preocc...

the way they scored it may be the reason for minimal dose response

The dose-response for each component, multivariable adjusted, and life expectancy
MVPA stands for moderate-to-vigorous physical activity
Diet quality score (0-100) defined by intake of 10 items