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Michelle Wille @duckswabber.bsky.social · 1d

Case study where partial culling was employed following detection of HPAI. Successfully eliminated and no local spread occurred = an example for the implementation of separate epidemiological units with a high level of biosecurity.
👉 www.tandfonline.com/doi/full/10....

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Michelle Wille @duckswabber.bsky.social · 1d

Wild bird species most at risk of contracting HPAI were those that are gregarious, tolerant of anthropic habitats, are non-migratory, and occupy the upper trophic level
👉 onlinelibrary.wiley.com/doi/full/10....?

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Michelle Wille @duckswabber.bsky.social · 1d

Simulated impacts of HPAI on the host population under baseline climate conditions varied from no impact to 100% mortality, depending on viral traits. Simulate 9-day advancement in spring migration timing = 🔺duration of HPAI outbreaks
👉 journals.plos.org/ploscompbiol...

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Michelle Wille @duckswabber.bsky.social · 1d

Overall mean biosecurity score across farms in Bangadesh 42/100, w 79% having poor biosecurity. Observational data revealed 99% of farms lacked foot baths and high interaction with wild birds (67%). Room for improvement
👉 www.sciencedirect.com/science/arti...

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Michelle Wille @duckswabber.bsky.social · 1d

H9N2 isolated from raw meat-based diets for dogs and cats produced in South Korea. Lineage Y280 lineage. stricter regulation of raw pet food required.
👉 www.sciencedirect.com/science/arti...

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Michelle Wille @duckswabber.bsky.social · 1d

systematic review of mathematical and machine learning models of Avian Influenza
👉 www.sciencedirect.com/science/arti...

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Michelle Wille @duckswabber.bsky.social · 1d

How to communicate zoonotic avian influenza spillover risk, PPE, and response. Co-producers generally preferred infographics to factsheets and suggested how sheets could be displayed on farms and disseminated within the poultry farming community.
👉 www.sciencedirect.com/science/arti...

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Michelle Wille @duckswabber.bsky.social · 1d

K-FluDB: A Novel K-Mer Based database for rapid subtype delination + reassortment detection.
👉 academic.oup.com/bioinformati...

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Michelle Wille @duckswabber.bsky.social · 1d

Does genetic selection for improved immune response, using Immunity+ GEBVs, can increase resilience to HPAI H5N1 in commercial dairy herds - 🔺 Immunity+ GEBVs = 24% less likely to require supportive treatment + lower milk loss.
👉 www.sciencedirect.com/science/arti...

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Michelle Wille @duckswabber.bsky.social · 1d

Bovine air-liquid interface cell cultures were infected by H7N7, AIV H9N2, swine H1N1, human H1N1(pdm09). swine H1N1 + H7N7 = highest replication titers and greatest loss of cilia. Cattle can act as a permissive host
👉 www.tandfonline.com/doi/full/10....

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Michelle Wille @duckswabber.bsky.social · 1d

Review of HPAI in cats: epidemiology, clinical and pathological presentations and management, and a current perspective on risk, testing and strategies to prevent infection
👉 journals.sagepub.com/doi/epub/10....

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Michelle Wille @duckswabber.bsky.social · 1d

pH-dependent H5N1 survival- virus persisting through cheese-making process + up to 120 days of aging in cheeses made with raw milk at pH 6.6 + 5.8. Ferrets fed raw-milk cheese or cheese suspension were not infected.
👉 link.springer.com/article/10.1...

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Michelle Wille @duckswabber.bsky.social · 1d

First report of influenza D virus in dairy cattle in Pakistan: 9/376 positive. Viruses clustered within the D/OK lineages, w 98.8–99.6% genetic identity to European and US viruses.
👉 www.mdpi.com/1999-4915/16...

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Michelle Wille @duckswabber.bsky.social · 1d

Bovine T cell responses to influenza remain poorly characterized - opportunity for future research
👉 www.mdpi.com/1999-4915/17...

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Michelle Wille @duckswabber.bsky.social · 1d

Influenza D virus among cattle in Poland w an estimated seroprevalence of 45.2%. No confirmation of IDV occurrence was obtained in any of the 274 sheep, goats, or horses.
👉 reference-global.com/article/10.2...

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Michelle Wille @duckswabber.bsky.social · 1d

Unlike past H5N1 outbreaks, majority of patients in the US outbreak have presented with conjunctivitis, either alone or alongside systemic symptoms. ocular-specific disease manifestation offers new clinical and screening implications
👉 www.mdpi.com/2076-0817/14...

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Michelle Wille @duckswabber.bsky.social · 1d

Higher polymerase activity of clade 2.3.4.4b H5N1 viruses + reassortants vs H9N2, H1N1, and H3N2 viruses = may explain zoontic. Reassortmen risk high.
👉 www.sciencedirect.com/science/arti...

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Michelle Wille @duckswabber.bsky.social · 1d

Up to 30% of commercial pasteurized milk in US is PCR +Ve. Pasteurization inactivates virus, but HA protein preserved. In mice, repeated oral exposure to inactivated virus did not alter mortality or worsen disease after H5N1 virus challenge.
👉 www.science.org/doi/10.1126/...

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Michelle Wille @duckswabber.bsky.social · 1d

mRNA-LNP chimeric HA vaccine induces strong stalk-specific antibodies in macaques, induces plasma cells in bone marrow. Vaccine-induced antibody protects mice from heterologous influenza virus challenges
👉 www.cell.com/cell-reports...

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Michelle Wille @duckswabber.bsky.social · 1d

4th case of H10N3 - female patient hospitalized in Nanning, China, in December 2024. history of exposure to live poultry. treated with a combination of baloxavir marboxil and oseltamivir.
👉 www.sciencedirect.com/science/arti...

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Michelle Wille @duckswabber.bsky.social · 1d

Sera from 10 age groups, across >80 years, in August 2024, British Columbia, Canada. H5N1 titres consistently lower but strongly associated with H1N1pdm09, peaked among young adults born 1997-2003
👉 www.medrxiv.org/content/10.1...

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Michelle Wille @duckswabber.bsky.social · 1d

HPAI sequences in store-bought milk linked to cattle outbreak - highlight potential + limitations of retail milk as a surveillance window.
👉 www.mdpi.com/1999-4915/17...

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Michelle Wille @duckswabber.bsky.social · 1d

H5N1 adaptation to bovine cells variable across 2.3.4.4b genotypes, limited in viruses predating the global expansion, determined by the viral internal gene cassette, not restricted to udder epithelial cells. PB2 M631L, key determinant of adaptation
👉 www.biorxiv.org/content/10.1...

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Michelle Wille @duckswabber.bsky.social · 1d

Cow+ and avian H5N1 = severe mastitis in goats, shed viruses in milk, transmitted to suckling kids. Viruses infected goat respiratory and mammary cells. More livestock surveillance
👉 www.sciencedirect.com/science/arti...

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Michelle Wille @duckswabber.bsky.social · 1d

Vaxxed mice + cattle w centralized consensus H5 vaccine via adeno vector = strong humoral + cellular immunity in mice and calves: vaccinated mice fully protected against lethal infection with multiple divergent H5N1 strains, incl the 2024 bovine isolate
👉 www.biorxiv.org/content/10.1...

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