Lightnews — Scholar-powered news

Reposted

IRB Barcelona @irbbarcelona.org · Aug 21

🤝 #IRBBarcelona Group Leader Cristina Mayor-Ruiz has co-authored a Perspective in #MolecularCell proposing the creation of a #EuropeanAlliance to accelerate the development of proximity-induced therapies.

More information here 🔗 www.irbbarcelona.org/en/news/scie...

🧪 #TargetedProteinDegradation

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IRB Barcelona @irbbarcelona.org · Jul 25

📷 Photo 51 — the image that changed the course of science.

Taken by British chemist and crystallographer #RosalindFranklin (born on this day in 1920) and Raymond Gosling, this X-ray diffraction image of DNA was the key to unlocking the double helix structure.

#WomeninSTEM

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IRB Barcelona @irbbarcelona.org · Apr 23

🔬Check out this recent spotlight in #MolecularCell, co-authored by Rory Whelan
Ferran José Duran & @crismayorruiz.bsky.social— Mutations that stick: Unexpected discovery of molecular glue mimicry👇

➡️ https://f.mtr.cool/zbljytwpcx

#ChemBio #MolecularGlue #MolecularGlues

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crismayorruiz.bsky.social @crismayorruiz.bsky.social · Mar 29

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Institute of Molecular Biotechnology @imbavienna.bsky.social · Mar 28

IMBA is recruiting a Junior Group Leader! Are you interested in starting your own lab, pursuing curiosity-driven basic research in the life sciences? Apply now to our group leader position. The deadline is May 28. Link is below.

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crismayorruiz.bsky.social @crismayorruiz.bsky.social · Mar 11

Congrats Will & team!!

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IRB Barcelona @irbbarcelona.org · Mar 8

🟣 On #WomensDay, we recognize the incredible women of #IRBBarcelona! Researchers, technicians, managers, and other professionals whose talent and dedication push the boundaries of knowledge.

Your work fuels discovery and paves the way for future generations of women in science.

Thank you! 🙌

#8M

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crismayorruiz.bsky.social @crismayorruiz.bsky.social · Mar 2

🧪 #Barcelona

Marco MILAN LAB @milanlab.bsky.social · Mar 2

www.lavanguardia.com/economia/202...

Barcelona se refuerza como capital biomédica

Con la llegada de más de mil investigadores a los nuevos edificios del Antic Mercat del Peix a partir del 2027, el entorno del parque de la Ciutadella se consolidará

www.lavanguardia.com

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IRB Barcelona @irbbarcelona.org · Feb 24

📌 La Dra. Ana Domostegui desarrolla un nuevo tipo de fármacos innovadores, denominados fármacos degradadores de proteínas, para el tratamiento del #CáncerdePáncreas.

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IRB Barcelona @irbbarcelona.org · Feb 24

📌 PROTECT:

En el marco de @cancergrand.bsky.social, el proyecto liderado por la Dra. @crismayorruiz.bsky.social desarrollará fármacos degradadores de proteínas para luchar contra los tumores pediátricos.

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IRB Barcelona @irbbarcelona.org · Feb 24

🟢 Ha sido un honor asistir hoy a la presentación de las Ayudas 2024 de la Asociación Española Contra el Cáncer.

¡Gracias Asociación Española contra el Cáncer por acompañarnos en este compromiso! Cada paso juntos nos acerca a un futuro sin #cáncer.

Descubre los proyectos del @irbbarcelona.org:

🧵👇

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IRB Barcelona @irbbarcelona.org · Feb 19

Avui hem tingut l’honor de rebre la visita de la consellera de Salut, Dra. Olga Pané. Ha conegut de primera mà els plans de futur de l'Institut i la importància dels nous laboratoris TRIP, una innovadora forma d'apropar #recerca fonamental i clínica.

Gràcies, consellera!

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IRB Barcelona @irbbarcelona.org · Nov 25

Hello, Blueskyers! Here's a comprehensive Starter Pack featuring all the IRB Barcelona faculty and affiliated members currently active on Bluesky. Keep an eye on this space—we'll be regularly updating it as more of our researchers join the platform. Thanks for following us!

go.bsky.app/6QPdeJj

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crismayorruiz.bsky.social @crismayorruiz.bsky.social · Feb 11

Happy #WomenScienceDay!
@irbbarcelona.org
🧪
youtube.com/shorts/p3rRs...

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IRB Barcelona @irbbarcelona.org · Jan 28

We are creating a dedicated website to honor the memory of Dr. Joan Guinovart and celebrate his remarkable legacy✨

Contribute by sharing your message through this form: ➡️ http://shorturl.at/YQn1l

Join us in paying tribute to his extraordinary impact.

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crismayorruiz.bsky.social @crismayorruiz.bsky.social · Jan 9

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Nature Chemical Biology @natchembio.nature.com · Jan 9

We asked a collection of chemical biologists, “What do you think are the most exciting frontiers or the most needed developments in your main field of research?”

You can read that they said in our Feature “Thoughts for the future” – Free to read in January. rdcu.be/d5Ksw

Thoughts for the future

Nature Chemical Biology - As Nature Chemical Biology approaches its third decade we asked a collection of chemical biologists, “What do you think are the most exciting frontiers or the most...

rdcu.be

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crismayorruiz.bsky.social @crismayorruiz.bsky.social · Dec 26

👋👋

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crismayorruiz.bsky.social @crismayorruiz.bsky.social · Dec 24

The office had never been so busy!!😅

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crismayorruiz.bsky.social @crismayorruiz.bsky.social · Dec 24

Our lab wishes you all a Merry Christmas!

We finish the scientific year at the @irbbarcelona.org Christmas party with the best costume ever!! 🤣🤣🤣

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crismayorruiz.bsky.social @crismayorruiz.bsky.social · Dec 16

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crismayorruiz.bsky.social @crismayorruiz.bsky.social · Dec 16

Huge congrats to #Alberto & #Inés, co-first authors! Amazing team effort with many other friends: Toni, Pep, Carlos, Caro, etc. @irbbarcelona.bsky.social

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crismayorruiz.bsky.social @crismayorruiz.bsky.social · Dec 16

Specifically, this allowed us to:
(i) Study the therapeutic efficacy of KRAS(G12V)-targeted degradation in vivo
(ii) Dissect tumor regression mechanisms (cell-intrinsic/extrinsic)
(iii) Investigate resistance

Curious to learn more? Take a look! www.biorxiv.org/content/10.1...

Targeted KRAS(G12V) degradation elicits efficient and durable lung adenocarcinoma regression in vivo

Recent drug discovery breakthroughs led to the approval of KRASG12C inhibitors in lung adenocarcinoma (LUAD). Unfortunately, clinical responses remain limited due to rapid resistance onset. Proteolysi...

www.biorxiv.org

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crismayorruiz.bsky.social @crismayorruiz.bsky.social · Dec 16

Chemical, tumor-specific modulation of KRAS(G12V) protein abundance served here to probe the therapeutic potential of oncoprotein degradation and to selectively dissect the biological outcomes!

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crismayorruiz.bsky.social @crismayorruiz.bsky.social · Dec 16

We developed a preclinical mouse model of lung adenocarcinoma in which we can induce selective KRAS(G12V) degradation in vivo, leveraging the dTAG system

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crismayorruiz.bsky.social @crismayorruiz.bsky.social · Dec 16

Hi BlueSky world!
We are thrilled to share our new preprint around oncoprotein degradation in vivo —a fantastic collaboration with our friends in Salamanca #lab_santamaria #ciccancer! 😃
@irbbarcelona.bsky.social #TPD #KRAS

👇
www.biorxiv.org/content/10.1...

Targeted KRAS(G12V) degradation elicits efficient and durable lung adenocarcinoma regression in vivo

Recent drug discovery breakthroughs led to the approval of KRASG12C inhibitors in lung adenocarcinoma (LUAD). Unfortunately, clinical responses remain limited due to rapid resistance onset. Proteolysi...

www.biorxiv.org

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Thorn-Seshold Lab @thornsesholdlab.bsky.social · Nov 17

Women in chemistry starter pack here: go.bsky.app/LjumNEg
#ChemSky
please repost :D

#ChemSky #realtimechem #FluorescenceFriday

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