CPCB
@cmupittcompbio.bsky.social
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Official account for the Joint Carnegie Mellon and University of Pittsburgh Computational Biology Program
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Steven Smeal
@stevenwsmeal.bsky.social
· Aug 15
In @natcomms.nature.com, we used robot-controlled cytokine pulses and imaging single receptor complexes and TF dynamics reveal that repeat, dose-conserving stimulation prolongs NEMO/IKK activation and shifts NF-κB dynamics via chromatin remodeling, enabling accurate single-cell models rdcu.be/ezTxF
Time-varying stimuli that prolong IKK activation promote nuclear remodeling and mechanistic switching of NF-κB dynamics
Nature Communications - Cells rely on limited numbers of transmembrane receptors to process signals from dynamic microenvironments. Using microfluidics and endogenous reporters, the authors track...
rdcu.be
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CPCB
@cmupittcompbio.bsky.social
· May 19
Congratulations to our graduates who attended the School of Medicine Class of 2025 Graduation yesterday! 🎓 💛
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CPCB
@cmupittcompbio.bsky.social
· Nov 27
We're looking forward to presenting this @workshopmlsb.bsky.social . This work was conceived and led by a group CPCB (@cmupittcompbio.bsky.social) students and learns a co-embedding of proteins and ligands to support ultra fast virtual screening. arxiv.org/pdf/2411.15418