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Reposted by Carla Hoge

Graham Coop @gcbias.bsky.social · 4h

We're excited to be recruiting an NIH funded postdoc to work in the Coop lab at UC Davis. We're specifically interested in candidates who are want to work at the intersection of human genetics, GWAS, and population genetics modeling. Please RT

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Reposted by Carla Hoge

Rachel Moran @rachelmoran.bsky.social · 5d

When sex chromosomes turnover, they can reset the rules of genomic conflict.
New preprint exploring how turnover reshapes barriers to gene flow through an “escape-hatch” model for mitonuclear conflict.
Any feedback would be welcome! ecoevorxiv.org/repository/v...

Resetting the rules: Sex chromosome turnover as an escape hatch for mitonuclear conflict

ecoevorxiv.org

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Jeremy BOO! Yoder 🎃💀🕷️ @jbyoder.org · 16d

New today: We're petitioning NSF to revert GRFP eligibility criteria to last year's terms, to avoid pulling the rug out from under the earliest of early-career scientists who had every reason to think they'd be able to apply this year. Sign and spread the word!

laurenkuehne.github.io/grfpChanges/

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Daniel Bolnick @danielbolnick.bsky.social · 19d

The GRFP announcement from NSF cuts out an entire cohort of 2nd year students from consideration, without warning. This is so deeply unfair that it warrants a formal protest from the scientific community. If someone wants to work with me to craft an open letter and solicit signatures, LMK.

Dan Garisto @dangaristo.bsky.social · 19d

New: After a long wait, the GRFP solicitation is live! Deadlines have been extended to early November, so applicants have a bit over a month to submit. www.nsf.gov/funding/oppo...

NSF Graduate Research Fellowship Program (GRFP)

www.nsf.gov

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Dan Garisto @dangaristo.bsky.social · 19d

As others have pointed out, the fellowship is now available only to 1st year grad students. (Left is last year, right is this year)

Be a U.S. citizen, national, or permanent resident
Intend to enroll or be enrolled full-time in a research-based Master's or doctoral degree program in an eligible Field of Study in STEM or STEM education (See Appendix and Section IV.3 for eligible Fields of Study
Never previously accepted a Graduate Research Fellowship
Declined any previously offered Graduate Research Fellowship by the acceptance deadline
Never previously applied to GRFP while enrolled in a graduate degree program
Never earned a doctoral or terminal degree in any field
Have completed no more than one academic year (according to institution's academic calendar) while enrolled in a graduate degree program (non-degree coursework must be clearly identified in the transcript and does not count toward this limit)
Individuals holding joint Bachelor's-Master's degrees who did not apply while enrolled in the joint program, may apply as second-year graduate applicants if enrolled in an eligible doctoral program the beginning of the academic year immediately following the academic award year of the joint degree
Individuals with prior graduate enrollment who have: (i) completed more than one academic year in any graduate degree-granting program, (ii) earned a previous master's degree of any kind (see guidance for joint Bachelor's-Master's degree-holders above), or (iii) earned a professional degree must meet the following requirements:
not enrolled in a graduate degree program at application deadline
two or more consecutive years past graduate degree enrollment or completion at the application deadline
Not be a current NSF employee.

Must, at the time of submission, be a U.S. citizen, national, or a permanent resident (“green-card” holder)
Must intend to enroll or be enrolled in an eligible research-based master's or doctoral degree program in an eligible field of study in STEM, including STEM education (See Appendix and Section IV.3 for eligible Fields of Study);
Never have previously accepted a Graduate Research Fellowship;
Have declined any previously offered Graduate Research Fellowship by the declination deadline (if applicable);
Have completed less than one academic year in a graduate degree program (according to the institution’s academic calendar; non-degree coursework must be clearly identified in the transcript and does not count toward this limit).
This means individuals in the following statuses at the time of application are eligible:

Undergraduate in the final (senior) year of a bachelor’s degree program
Bachelor’s degree-holder with NO enrollment in a graduate degree program (non-degree graduate coursework allowed)
Individual enrolled in a joint bachelor’s-master’s degree program with at least three undergraduate years completed
First-year graduate student in their first graduate degree program with less than one academic year completed in the degree program (according to institution’s academic calendar)
Individuals enrolled in joint bachelor’s-master’s degree programs are considered graduate students. For GRFP, joint bachelor’s-master’s degrees are defined as degrees concurrently pursued and awarded.
Not be a current NSF employee.

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Reposted by Carla Hoge

Dan Garisto @dangaristo.bsky.social · 19d

New: After a long wait, the GRFP solicitation is live! Deadlines have been extended to early November, so applicants have a bit over a month to submit. www.nsf.gov/funding/oppo...

NSF Graduate Research Fellowship Program (GRFP)

www.nsf.gov

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Lino Ferreira @linoafferreira.bsky.social · Sep 10

Delighted to see this paper with @anaignatieva.bsky.social now published in Genetics!
academic.oup.com/genetics/adv...

We tackle a thorny issue arising in statistical tests for genetic interactions (epistasis) using ancestral recombination graphs (ARGs)... 🧵

Phantom epistasis through the lens of genealogies

Abstract. Phantom epistasis arises when, in the course of testing for gene-by-gene interactions, the omission of a causal variant with a purely additive ef

academic.oup.com

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Rachel Moran @rachelmoran.bsky.social · Sep 4

First pop gen paper from our lab! We find repeated evolutionary turn over of sex chromosomes in darters contributes to reproductive isolation. Turnover may be an escape hatch to resolve mitonuclear conflict & neo sex chromosomes evolved via a rare recessive mutation. www.biorxiv.org/content/10.1...

Top left: Results of genome-wide association study (GWAS) for sex in E. caeruleum, E. radiosum, and E. spectabile showing sex chromosome turnover has occurred repeatedly. Top right: Phylogeny showing sex chromosome turnover in darters and non-darter percids. Chromosome 9 is the putative ancestral sex chromosome, shared by Perca flavescens and multiple members of the orangethroat darter complex (e.g., E. spectabile, E. pulchellum). Bottom: Schematic depicting repeated turnover of sex chromosomes as a mechanism to resolve mitonuclear conflict and promote speciation.

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Natanael Spisak @natanaels.bsky.social · Sep 3

Very happy to share our work on signature SBS5. See Molly's thread for a short summary

Molly Przeworski @mollyprz.bsky.social · Sep 2

In these dark times, it comes as a rare pleasure to highlight @natanaels.bsky.social ‬ & @marcdemanuel.bsky.social's work on germline and somatic mutations in humans. 1/n
www.biorxiv.org/cgi/content/...

Collateral mutagenesis funnels multiple sources of DNA damage into a ubiquitous mutational signature

Mutations reflect the net effects of myriad types of damage, replication errors, and repair mechanisms, and thus are expected to differ across cell types with distinct exposures to mutagens, division ...

www.biorxiv.org

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Molly Przeworski @mollyprz.bsky.social · Sep 2

In these dark times, it comes as a rare pleasure to highlight @natanaels.bsky.social ‬ & @marcdemanuel.bsky.social's work on germline and somatic mutations in humans. 1/n
www.biorxiv.org/cgi/content/...

Collateral mutagenesis funnels multiple sources of DNA damage into a ubiquitous mutational signature

Mutations reflect the net effects of myriad types of damage, replication errors, and repair mechanisms, and thus are expected to differ across cell types with distinct exposures to mutagens, division ...

www.biorxiv.org

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Catherine Rampell @crampell.bsky.social · Aug 29

Trump admin planning to change student visas from lasting for duration of academic program to fixed 4-yr term, and then much harder to renew
Could destroy US ability to attract global talent, particularly those seeking advanced degrees in STEM. The median time to complete a PhD is 5.7 yrs per NSF.

Trump Deals A New Immigration Blow To International Students

Trump officials have proposed a new rule limiting international students to fixed periods of entry, making a U.S. education more precarious.

www.forbes.com

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Carla Hoge @choge.bsky.social · Aug 24

From personal experience, an expensive private college school was, in practice, much cheaper than many of my state school options because of need-based financial aid.

Carla Hoge @choge.bsky.social · Aug 24

This seems like a wildly useful resource for students applying to college and trying to compare costs - collegetables.info

The cost after need-based financial aid varies widely, and often not in ways one might expect

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Laura K Hayward @lkhayward.bsky.social · Aug 23

Why do males and females often differ in traits?
The expected answer: selection.
But our new paper in GENETICS shows that genetic drift alone can generate sexual dimorphism — even when male & female optima are the same

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Laura K Hayward @lkhayward.bsky.social · Aug 23

Full paper now out in GENETICS:
The relationship between sexual dimorphism and intersex correlation: do models support intuition?
🔗 academic.oup.com/genetics/art...
#Evolution #QuantGenetics @GeneticsGSA

The relationship between sexual dimorphism and intersex correlation: do models support intuition?

Abstract. The evolution of sexual dimorphism (the difference in average trait values between females and males, SD), is often thought to be constrained by

academic.oup.com

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Will Ratcliff @wcratcliff.bsky.social · Aug 12

Not sure how many scientists here have tried Claude Code or similar command line coding assistants. I had a complicated family property tax problem that was best solved by a brute force Monte Carlo simulation approach, so I spent a few days coding up and analyzing a model with Claude Code.

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Hakhamanesh Mostafavi @hakha.bsky.social · Jul 25

I'm thrilled that my lab at NYU is now supported by an NIH MIRA grant! I'm looking to hire 1-2 senior lab members (outstanding postdoc candidates or experienced staff scientists) with expertise in computational or statistical methods in human genetics or genomics. Please share!

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Julia Kreiner @jmkreiner.bsky.social · Jun 19

hey folks! so looking forward to seeing everyone at @sse-evolution.bsky.social! if you have space on your schedule, come check out the Kreiner lab contigent on Sunday morning in the Adaptation VI symposium.

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Governor JB Pritzker @govpritzker.illinois.gov · Jun 15

Let me remind you: we don't have kings in America — and I won't bend the knee to one.

Never stop speaking out and showing up, Illinois.

This is what democracy in action looks like.

'No Kings' protests in Chicago, suburbs, nationwide fill streets, plazas to oppose Trump policies

Thousands gathered in Daley Plaza and in suburban events in protests timed to coincide with a military parade in Washington celebrating the Army's 250th anniversary and President Donald Trump's 79th b...

chicago.suntimes.com

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Mark Jacob @markjacob.bsky.social · Jun 14

Here’s a New York Times photo of the Chicago “No Kings” rally. NYT said the march that followed spanned at least 10 blocks.

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Carla Hoge @choge.bsky.social · Jun 14

The #NoKings march in Chicago stretched for blocks and blocks and blocks - No monarchs here! (except for butterflies and drag kings + queens)

A woman (me) at the no kings march in Chicago, holding a large rainbow flag. Many people and a few tall buildings in the background, and the sky is a beautiful partly cloudy blue.

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John Novembre @jnovembre.bsky.social · Jun 5

Excited for our publication on how the geographic scale of a sample affects the discovery of rare, deleterious variants to be out this week. With a mix of theory, simulation, and data analysis, we show when samples are narrow vs broad, the number of variants discovered and their frequencies change

PNAS

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

www.pnas.org

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Jeff Spence @jeffspence.github.io · Jun 2

I'm excited to announce that I'll be starting a lab at UCSF in the @ihgatucsf.bsky.social and @ucsf-epibiostat.bsky.social in July.

We'll work at the intersection of statistical genetics, population genetics, and machine learning.

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Jonathan Pritchard @jkpritch.bsky.social · Jun 1

I have an opportunity to hire a staff scientist for my lab. Looking for someone with outstanding skillset in ML/statistics, genomics applications; interest in mentoring, strong publication record, PD experience required.

Email CV to me+cc my assistant (see 'contact' on my website). Ad to follow.

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Maggie Steiner @maggiesteiner.bsky.social · Jun 3

Out today in @pnas.org! www.pnas.org/doi/10.1073/...

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