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brinazarski

@brinazarski.at.app.wafrn.net

38 followers 110 following 380 posts

pfp credit: theratpy on tumblr disabled individual in xyr 30s any pronouns[...] View full profile at https://app.wafrn.net/blog/brinazarski

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brinazarski @brinazarski.at.app.wafrn.net · 16h

i need to make a poll. i have a hypothesis

Reposted by brinazarski

Chise @sailorrooscout.bsky.social · 11d

Their efficacy was confirmed against LIVE viruses including Ebola, Marburg, Nipah, Hendra, SARS-CoV, SARS-CoV-2 (COVID-19), AND Middle East Respiratory Syndrome (MERS).

The study has been published in Science Advances. YES, it is PEER-REVIEWED.
• www.science.org/doi/10.1126/...

🧪🧵⬇️

ABSTRACT
Viral pandemics continue to threaten global health and economic stability. Despite medical advances, the absence of broad-spectrum antivirals (BSAs) prevents rapid responses to emerging viral threats. This is largely due to the lack of universal drug targets across diverse viral families and high variability among viral proteins.
In this study, we evaluated 57 synthetic carbohydrate receptors (SCRs) for antiviral activity in cellulo using pseudotyped virus particles (PVPs) from six high-risk viruses across three families: Paramyxoviridae, Filoviridae, and Coronaviridae.
Four SCRs inhibited all tested PVPs, and their efficacy was confirmed against live viruses including SARS-CoV-2, MERS-COV, EBOV, MARV, NiV, and HeV.
Notably, SCR005 and SCR007, which exhibited minimal toxicity, significantly reduced SARS-CoV-2 infection in a severe animal model with a single dose.
Mechanistic studies suggested that SCRs bind viral envelope N-glycans, blocking viral attachment and/or fusion.
These results identify conserved viral N-glycans as promising BSA targets and establish SCRs as candidate prophylactic agents against enveloped viruses with pandemic potential.

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Reposted by brinazarski

Chronic Illness Humor @chronicillness.bsky.social · 23h

@alexhaagaard Chronically ill people are like "I know a spot" and then direct the phlebotomist to the good vein

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Reposted by brinazarski

Chronic Illness Humor @chronicillness.bsky.social · 23h

a glass of water with a post on top of it:

@KevinFarzad I don't get why feel bad bad all the time when I drink 8 glasses of water a year just like you're supposed to

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brinazarski @brinazarski.at.app.wafrn.net · 1d

@fangyy.at.app.wafrn.net they implemented this for you so you can spread rabies more effectively :ablobfoxhyperowo:

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Reposted by brinazarski

Spheal Posting @sphealposting.bsky.social · 1d

A meme showing a text messages notification from Dad saying "why you crying so damn loud"
Below is a game screenshot from pokemon heartgold soulsilver of a shiny spheal in the safari zone. The game text says "the wild spheal fled!"

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brinazarski @brinazarski.at.app.wafrn.net · 1d

It’s Wafsday My Pals

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brinazarski @brinazarski.at.app.wafrn.net · 2d

you know. the mcdonald’s coca cola could probably fix me

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brinazarski @brinazarski.at.app.wafrn.net · 2d

i have a migraine right now and i feel like zeus when he gave birth to athena

brinazarski @brinazarski.at.app.wafrn.net · 2d

the creature does not care that *i* took her to the vet. she had a hard day and she wants to cuddle #she-had-an-x-ray #she’s-spiderman-now

brinazarski @brinazarski.at.app.wafrn.net · 2d

wafbing wafbing bing

https://m.youtube.com/watch?v=9MWtNC_rZmI #duolingo

Reposted by brinazarski

isabel @isabelroses.com · 6d

this post hasn't aged very well at all

isabel @isabelroses.com · 21d

are you a soy webdev macbook or low-level nixos framework person ?

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Reposted by brinazarski

RAT @doctor4t.dev · 4d

(art by @astronyu.bsky.social)

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brinazarski @brinazarski.at.app.wafrn.net · 2d

THE CREATURE IS FINE!

Reposted by brinazarski

MariBean @maribean.bsky.social · 2d

A mulching mower is must. If the leaves are really thick, rake some to the edges then use the mower.

I bag the first few rounds of leaf-fall, dump the bags in piles in the gardens. Last few rounds get mulched, left on the yard. Only areas I keep clear are low areas I made for spring melt drainage.

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brinazarski @brinazarski.at.app.wafrn.net · 2d

but we did invent jesusween #i-think

brinazarski @brinazarski.at.app.wafrn.net · 2d

how does she know… #the-creature

A drowsy classic silver tabby cat laying next to her cage.

brinazarski @brinazarski.at.app.wafrn.net · 3d

i used to love halloween but i’ve had too many horrible things happen around this time of year. i also generally loathe fall and winter and those seasons make me severely depressed so there’s that also.

i’ve given myself permission to be festive but i just… don’t… want to. i just barely w[...]

See complete post at app.wafrn.net

app.wafrn.net is a Wafrn server. Wafrn is a federated social media inspired by Tumblr, join us and have fun!

app.wafrn.net

Reposted by brinazarski

deadpan @deadpan-c.at.app.wafrn.net · 3d

take your age. add 4. that's not your age.

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Reposted by brinazarski

Retro Tech Dreams @retrotechdreams.bsky.social · 3d

Adobe Photoshop 5.5 (1999) is still a powerful photo editor, usable today and runs on modern Windows in compatibility mode.

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Reposted by brinazarski

Rafael Belenos @belenos.bsky.social · 3d

The death of European Portuguese starts with Rambo III

A social media post by user "ryan-sometimes" titled "My favourite example of the domino effect." The image shows a meme format with a man in a blue shirt and khaki pants crouching down to push over the first in a line of dominoes of varying sizes, with each subsequent domino getting progressively larger. The smallest domino is labeled "Gerard Way witnesses 9/11" and the largest domino at the end is labeled "The slow and painful death of European Portuguese." This visual metaphor illustrates how a small initial event can lead to increasingly significant consequences, referencing the cultural chain reaction described in the previous post.

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Reposted by brinazarski

Chronic Illness Humor @chronicillness.bsky.social · 3d

Learn why people trust wikihow

PSYCHOLOGICAL HEALTH > STRESS MANAGEMENT

HOW to ENJOY YOUR DOCTOR'S APPOINTMENTS

[woman sleeping in bed]

1.Don't Go.

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Reposted by brinazarski

Chronic Illness Humor @chronicillness.bsky.social · 3d

Me, going outside for the first time in weeks, after a nasty health flare: dafuq is this?

[skeleton looking at a flower while kneeling]

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brinazarski @brinazarski.at.app.wafrn.net · 3d

@gabboman.at.app.wafrn.net should make a shitposting account called @gabbopentin #:3

Reposted by brinazarski

Pavel @spavel.bsky.social · 4d

"Slashdot: What's the reason OneDrive tells users this setting can only be turned off 3 times a year?

[Microsoft's publicist chose not to answer this question.]"

Microsoft's OneDrive Begins Testing Face-Recognizing AI for Photos (for Some Preview Users) - Slashdot

I uploaded a photo on my phone to Microsoft's "OneDrive" file-hosting app — and there was a surprise waiting under Privacy and Permissions. "OneDrive uses AI to recognize faces in your photos.....

slashdot.org

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