Lightnews — Scholar-powered news

Christine Rabinak, PhD, MBA @brainsbeesbikes.bsky.social · 6d

A new study from Michigan finds that doxyPEP (post-exposure doxycycline) is underused — even in populations at higher risk for bacterial STIs.

🔗 doi.org/10.1177/0956...

#PublicHealth #STIPrevention #Epidemiology

A cross-sectional analysis of doxyPEP use and outcomes in Michigan, United States - Christen J Arena, Nathan A Everson, Rachel M Kenney, Indira Brar, Smitha Gudipati, Nicholas Yared, Susan L Davis, Mi...

Background: In 2024, national guidance was issued for doxycycline post-exposure prophylaxis (doxy-PEP) to prevent bacterial sexually transmitted infections (STI...

doi.org

Christine Rabinak, PhD, MBA @brainsbeesbikes.bsky.social · 6d

New collaborative study identifies 4-substituted phenylpyrazolidinone derivatives as potent inhibitors of Ku70/80-DNA-PK, a key enzyme in the DNA repair pathway.

🔗 doi.org/10.1039/d5md...

#MedicinalChemistry #DNARepair #Oncology #Pharmacology

Christine Rabinak, PhD, MBA @brainsbeesbikes.bsky.social · 6d

A short 4–amino acid intracellular motif of the immune checkpoint protein VISTA directly inhibits growth receptor signaling (EGFR/HER2), suppressing tumor growth.

🔗 doi.org/10.1158/0008...

#Oncology #Immunotherapy #CancerBiology

A Four Amino Acid Intracellular Motif of VISTA Blocks Growth Receptor Signaling in Cancer Cells to Induce Tumor Suppression

Characterization of the molecular mechanisms of VISTA and elucidation of therapeutic vulnerabilities in a class of triple-negative breast cancer that strongly expresses VISTA in tumor cells could info...

doi.org

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Christine Rabinak, PhD, MBA @brainsbeesbikes.bsky.social · 6d

A fast, non-enzymatic thermal method (90 °C for 15 min) efficiently converts the prodrug ceftaroline fosamil (Teflaro®) into its active form.

🔗 doi.org/10.1099/jmm....

#Antibiotics #PharmacyResearch #DrugDiscovery

Rapid deprotection and purification of ceftaroline free base from its phosphoramidate prodrug

Contemporary pharmaceutical design often incorporates functional groups to improve the pharmacokinetic/pharmacodynamic profile of a desired active chemical entity. These compounds are known as prodrug...

doi.org

Christine Rabinak, PhD, MBA @brainsbeesbikes.bsky.social · 6d

A clever microbiology nudge—a simple comment added to lab reports—led to a 4.6× increase in use of narrow-spectrum antibiotics for Streptococcus pneumoniae bloodstream infections.

🔗 doi.org/10.1017/ash....

#AntibioticStewardship #BehavioralScience #Microbiology

A little nudge goes a long way: assessing the impact of a microbiology nudge comment on narrow-spectrum antibiotic use in uncomplicated Streptococcus pneumoniae bloodstream infections | Antimicrobial ...

A little nudge goes a long way: assessing the impact of a microbiology nudge comment on narrow-spectrum antibiotic use in uncomplicated Streptococcus pneumoniae bloodstream infections - Volume 5 Issue...

doi.org

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Christine Rabinak, PhD, MBA @brainsbeesbikes.bsky.social · 6d

Near-infrared light at 750 & 950 nm reduces mitochondrial hyperactivity and oxidative stress after simulated ischemia/reperfusion.

A simple, non-drug approach that speeds mitochondrial recovery and limits cell death — potential implications for stroke therapy.

🔗 doi.org/10.3390/anti...

doi.org

Christine Rabinak, PhD, MBA @brainsbeesbikes.bsky.social · Sep 15

📚 New in RSAP by Wayne State EACPHS and colleagues: Core journals in #PharmacyPractice—developed using theory + data to define the field’s scholarly boundaries.

A must-read for faculty, editors, & promotion committees.

🔗 doi.org/10.1016/j.sa...

#PharmEd #AcademicPublishing

Redirecting

doi.org

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Christine Rabinak, PhD, MBA @brainsbeesbikes.bsky.social · Sep 15

💉 New in JICM: Long-acting insulin does not increase hypoglycemia risk in ICU patients with diabetes.

A promising insight for safe glycemic control during critical illness. 🏥

journals.sagepub.com/doi/10.1177/...

#ICU #PharmacyResearch #DiabetesCare

Sage Journals: Discover world-class research

Subscription and open access journals from Sage, the world's leading independent academic publisher.

journals.sagepub.com

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Christine Rabinak, PhD, MBA @brainsbeesbikes.bsky.social · Sep 15

🚨 MDR Gram-negatives?
Aztreonam–avibactam may be the answer.

WSU EACPHS faculty and students review the current evidence in Pharmacotherapy 🧫

🔗 journals.sagepub.com/doi/10.1177/...

#PharmacyResearch #MBL #AntimicrobialStewardship #InfectiousDiseases

Sage Journals: Discover world-class research

Subscription and open access journals from Sage, the world's leading independent academic publisher.

journals.sagepub.com

Christine Rabinak, PhD, MBA @brainsbeesbikes.bsky.social · Sep 15

Burnout to balance 💥💗

Wayne State EACPHS PharmD alumni Drs. Krystle & Josh Raub reflect on their dual-pharmacist life & how they reclaimed joy, purpose, & family.

Read their story: doi.org/10.1093/ajhp...

#Pharmacy #Wellness #CareerBalance

Burnout to balance: A dual-pharmacist couple’s story of career and family resilience

We first met the summer before starting pharmacy school at the Eugene Applebaum College of Pharmacy and Health Sciences at Wayne State University. Excited

doi.org

Christine Rabinak, PhD, MBA @brainsbeesbikes.bsky.social · Sep 15

Wayne State EACPHS applauds Frappa et al.’s sustained impact + calls for next-gen analytics (e.g., DiD, PSM, Bayesian ITS).

Smart stewardship = saved antibiotics, preserved outcomes. 👏

🔗 pmc.ncbi.nlm.nih.gov/articles/PMC...

#IDPharmD #AntibioticStewardship #InfectiousDiseases #PublicHealth

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Christine Rabinak, PhD, MBA @brainsbeesbikes.bsky.social · Sep 15

An EHR-based alert improved adherence to CDC-recommended trichomoniasis therapy. Smart tech, better outcomes. Wayne State EACPHS

pmc.ncbi.nlm.nih.gov/articles/PMC...

#DigitalHealth #PharmacyPractice

Impact of an Interruptive Alert on the Number of Women Receiving CDC-Recommended Therapy for Trichomoniasis

Background: The 2021 Centers of Disease Control and Prevention (CDC) sexually transmitted infection treatment guidelines recommend a 7-day course of metronidazole or single-dose tinidazole for women w...

pmc.ncbi.nlm.nih.gov

Christine Rabinak, PhD, MBA @brainsbeesbikes.bsky.social · Sep 15

Walking forward or backward engages different brain pathways—myelin water imaging at Wayne State EACPHS reveals novel insights in MS.

link.springer.com/article/10.1...

#Neuroscience #MultipleSclerosis

Neural correlates of forward and backward walking in MS: insights from myelin water imaging - Experimental Brain Research

Mobility impairments and increased fall risk are common in multiple sclerosis (MS), resulting from myelin degradation in motor pathways. While forward walking is a common mobility assessment, backward...

link.springer.com

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Christine Rabinak, PhD, MBA @brainsbeesbikes.bsky.social · Sep 15

Re-evaluating duration: For stable cancer patients, short-course antibiotics may reduce side effects without compromising care. Wayne State EACPHS

pmc.ncbi.nlm.nih.gov/articles/PMC...

#InfectionControl #CancerCare

Is Shorter Better in Oncology Patients, Too? A Retrospective Cohort Study of Short- Versus Long-Course Antibiotic Therapy for Uncomplicated Infections in Solid Tumor Patients Receiving Care in Ambulat...

This retrospective cohort study evaluated short- versus long-course antibiotics for uncomplicated infections in ambulatory solid tumor patients. Among 303 patients, outcomes were similar between group...

pmc.ncbi.nlm.nih.gov

Christine Rabinak, PhD, MBA @brainsbeesbikes.bsky.social · Sep 15

Starting eravacycline sooner saves lives. This multicenter study led by Wayne State EACPHS shows earlier use improves clinical outcomes in vulnerable patients.

journals.asm.org/doi/10.1128/...

#PharmacyResearch #IDPharmacy

Eravacycline use in immunocompromised patients: multicenter evaluation of timely versus late initiation on clinical outcomes | Microbiology Spectrum

This multicenter, retrospective study evaluates the impact of timely versus late initiation of eravacycline (ERV) in immunocompromised patients with multidrug-resistant (MDR) bacterial infections. Imm...

journals.asm.org

Christine Rabinak, PhD, MBA @brainsbeesbikes.bsky.social · Sep 15

Assessment is more than a checkbox. This research by Wayne State EACPHS and colleagues uncovers how pharmacy faculty interpret COEPA strategies—what’s working, what’s not.

www.ajpe.org/article/S000...

#AcademicMedicine #TeachingExcellence

Across the Annual Meeting Tables: Evaluating Pharmacy Faculty Members’ Understanding of COEPA Assessment Strategies

To assess pharmacy educators' knowledge and perceptions of Curricular Outcomes and Entrustable Professional Activities (COEPA) and ACPE Standards 2025 assessment strategies.

www.ajpe.org

Christine Rabinak, PhD, MBA @brainsbeesbikes.bsky.social · Sep 15

📘 Just published in Brain Sciences by Wayne State EACPHS: MHFA training improves pharmacy students’ & pharmacists’ confidence and mental health literacy.

Training pharmacists to recognize and respond to mental health crises = stronger, safer communities. 💊🧠

pmc.ncbi.nlm.nih.gov/articles/PMC...

The Effect of Mental Health First Aid Training on Pharmacist and Pharmacy Student Confidence and Knowledge: A Systematic Review and Meta-Analysis

Background/Objectives: Pharmacists are highly accessible healthcare providers who have frequent, repeated contact with diverse patient populations. They are poised to offer expanded and comprehensive ...

pmc.ncbi.nlm.nih.gov

Christine Rabinak, PhD, MBA @brainsbeesbikes.bsky.social · Sep 13

My labs tell the story:
📆 June 25, Aug 12, Sept 5 = transfusions.
Talzenna-induced anemia isn’t iron deficiency.
It’s marrow suppression, showing up as pancytopenia on CBC.

#CancerCare #PharmacyEducation #Talzenna #OncologyPharmacy #AnemiaAwareness

Christine Rabinak, PhD, MBA @brainsbeesbikes.bsky.social · Sep 13

Two anemias, two mechanisms, two treatments:
🩸 Iron deficiency = low raw materials → give iron.
💊 Bone marrow suppression = broken factory → transfusion/supportive care.
Mechanism matters.

#PharmD #OncologyPharmacy #DrugMechanisms #ClinicalPharmacy #Pharmacology

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Christine Rabinak, PhD, MBA @brainsbeesbikes.bsky.social · Sep 13

Not all anemia needs iron.
Talzenna® suppresses bone marrow → fewer red blood cells, even when iron is normal.
Supportive care = transfusions, not iron pills.

#Oncology #PharmacyEducation #Talzenna #Pharmacology #AnemiaAwareness

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Christine Rabinak, PhD, MBA @brainsbeesbikes.bsky.social · Aug 29

🦠 Overusing vancomycin in pneumonia treatment?

A study co-authored by WSU EACPHS shows that MRSA nasal PCR testing shortens vancomycin duration more effectively than culture-based methods—supporting better antibiotic stewardship.

doi.org/10.1177/8755...

#MRSA #Vancomycin #InfectiousDiseases

Sage Journals: Discover world-class research

Subscription and open access journals from Sage, the world's leading independent academic publisher.

doi.org

Christine Rabinak, PhD, MBA @brainsbeesbikes.bsky.social · Aug 29

🧬 Curious how CRISPR/Cas9 could transform cancer therapy?

This review led by WSU EACPHS dives deep into nanotech delivery strategies—lipid NPs, exosomes, polymers—to target cancer cells with gene-editing precision.

doi.org/10.3390/cell...

#CRISPR #CancerResearch #Nanotechnology #WayneState

doi.org

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Christine Rabinak, PhD, MBA @brainsbeesbikes.bsky.social · Aug 29

🧠 A new dual-action therapeutic candidate for Parkinson’s?

D-583, developed by WSU EACPHS, is a dopamine agonist that selectively chelates Fe(II) and protects neurons from ferroptosis.

Published in Neurochemical Research
🔗 doi.org/10.1007/s110...

#Parkinsons #Ferroptosis #Neuroprotective

Biological Characterization of the Anti-ferroptotic Properties of a Novel Anti-Parkinsonian Iron (II) Selective Dopamine Agonist, D-583 - Neurochemical Research

Here, we report the in vitro and in vivo characterization of a novel hybrid D2/D3 agonist and iron (II)-specific chelator, D-583, as a multi-target-directed ligand for Parkinson’s disease (PD). In our...

doi.org

1

Christine Rabinak, PhD, MBA @brainsbeesbikes.bsky.social · Aug 29

🦠 Metallo-β-lactamase inhibitors have entered the chat.

Cefepime–taniborbactam, the first of its kind, shows promise against stubborn multi-drug-resistant infections.

🔗 doi.org/10.1002/phar...

#AntibioticResistance #MBLs #WayneState #Pharmacotherapy #EACPHS

Christine Rabinak, PhD, MBA @brainsbeesbikes.bsky.social · Aug 29

🧪 What drives β-cell failure in diabetes? A new article by WSU EACPHS points to a signaling module involving RhoGDIβ, Rac1, and CARD9 as key culprits in hyperglycemia-induced islet dysfunction.

🔗 doi.org/10.3390/cell...

#Diabetes #BetaCellDysfunction #Rac1 #MolecularSignaling

doi.org