Author | Lightnews

Adrienne Asher @asheradrienne.bsky.social · Jul 20

89% of patients with Mast Cell Activation Syndrome (MCAS) had significant reduction in symptoms from GLP-1RAs. It is thought that these drugs stabilize mast cells and reduce inflammation. The authors recommend future randomized trials of these drugs in patients with #LongCOVID.

Utility of Glucagon-Like-Peptide-1-Receptor Agonists in Mast Cell Activation Syndrome

Introduction: Mast cell (MC) activation syndrome (MCAS) is a collection of illnesses rooted in inappropriate MC activation with little to no neoplasti…

www.sciencedirect.com

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Adrienne Asher @asheradrienne.bsky.social · Jul 19

Facinating article about Dr. Michael Peluso, MD, an infectious disease clinician and researcher, as well as the director and one of the co-creators of the large Long Term Impact of Infection with Novel Coronavirus (LIINC) project at UCSF. #LongCovid

"Excited Every Day": Dr. Michael Peluso on LIINC, Long COVID and ME/CFS - Health Rising

Dr. Michael Peluso talks about the LIINC long COVID project, why he's excited every day about long COVID, and what he hopes the next 5 years will bring.

www.healthrising.org

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Adrienne Asher @asheradrienne.bsky.social · May 18

The Bateman Horne Center published a new Clinical Care Guide for managing #ME/CFS, #LongCOVID and Infection-associated chronic conditions (IACCs). The guide offers advice on common comorbidities, assessment tools, clinical pearls, and treatments for these very complex diseases.

Sympathetic Neural Overdrive, Vascular Dysfunction and Diminished Exercise Capacity in Long COVID-19 Patients: A Long-Term Study of Cardiovascular Sequelae | American Journal of Physiology-Regulatory,...

Background: We have recently showed that severe COVID patients have neurovascular dysfunction, cardiac morpho-functional alterations, and attenuated exercise capacity. However, whether these alteratio...

journals.physiology.org

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Adrienne Asher @asheradrienne.bsky.social · May 18

Two years later, 18 #LongCOVID patients still showed increased sympathetic nerve activity, vascular dysfunction, impaired exercise capacity. Elevated markers of endothelial stress + oxidative damage point to the cardiovascular effects that may underlie persistent fatigue & shortness of breath.

Sympathetic Neural Overdrive, Vascular Dysfunction and Diminished Exercise Capacity in Long COVID-19 Patients: A Long-Term Study of Cardiovascular Sequelae | American Journal of Physiology-Regulatory,...

Background: We have recently showed that severe COVID patients have neurovascular dysfunction, cardiac morpho-functional alterations, and attenuated exercise capacity. However, whether these alteratio...

journals.physiology.org

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Reposted by Adrienne Asher

Eric Topol @erictopol.bsky.social · May 16

On finding treatments for #LongCovid
“What’s so sad here is people are so desperate, and we don’t have anything [of so many solid candidates] validated."
gift link: www.washingtonpost.com/wellness/202...

Long covid patients are desperate for treatments. These trials may help.

Some trials are focusing on drugs that target the immune system, which is affected by different pathways to long covid.

www.washingtonpost.com

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Adrienne Asher @asheradrienne.bsky.social · May 18

Nicotinamide, an NAD precursor, also shows promise in helping #LongCovid symptoms.

Nicotinamide modulates gut microbial metabolic potential and accelerates recovery in mild-to-moderate COVID-19 - Nature Metabolism

In a prospective, double-blind, randomized, placebo-controlled trial, supplementation with a combination of conventional and gut-targeted nicotinamide was safe and effective in ameliorating COVID-19 s...

www.nature.com

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Adrienne Asher @asheradrienne.bsky.social · May 18

Saw my new cardiologist a few days ago for #LongCovid issues (PEM, POTS). Two techs walk in, unmasked. I politely ask them to wear masks. “What?! Me?!” Yes, please. You. Why must this always be an issue? So tired of negotiating every. single. thing.

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Adrienne Asher @asheradrienne.bsky.social · May 15

Coffee, #LongCovid, and fatigue.

Can Caffeine Help with Exercise in Fibromyalgia, ME/CFS and Long COVID? - Health Rising

A study suggests that caffeine helps fibromyalgia enjoy exercise more and exercise longer. Could the same be true for chronic fatigue syndrome (ME/CFS) and long COVID?

www.healthrising.org

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Adrienne Asher @asheradrienne.bsky.social · May 13

Perhaps most fascinating is how mindfulness recalibrates our relationship with difficult experiences; pain, anxiety, and other challenging sensations become objects of curious attention rather than threats to be avoided, creating a fundamental shift in how we embody distress.
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Adrienne Asher @asheradrienne.bsky.social · May 13

This neurological remodeling translates to measurable health outcomes: reduced inflammatory markers, improved immune function, enhanced vagal tone, and greater heart rate variability—all physiological signatures of resilience.
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Adrienne Asher @asheradrienne.bsky.social · May 13

Published research from Harvard’s Mass. General Hospital reveals that 8 weeks of regular mindfulness practice physically thickens brain regions involved in bodily awareness, while simultaneously reducing activity in the brain circuit responsible for mind-wandering and self-referential thinking.
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Adrienne Asher @asheradrienne.bsky.social · May 13

Using single-cell analysis, scientists in China uncovered widespread changes in alternative polyadenylation of mRNA in brain-related cells after COVID. These disruptions may contribute to neurological and psychiatric symptoms observed in #LongCOVID patients.

www.biorxiv.org/content/10.1...

www.biorxiv.org

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Adrienne Asher @asheradrienne.bsky.social · May 13

A preprint from Germany reports that 68 individuals with #LongCOVID had unusually active CD8+ T cells and elevated IL-3 levels. These immune signatures could help identify patients at risk and guide development of targeted therapies.

www.sciencedirect.com/science/arti...

Hyper-reactivity of CD8+ T cells and high expression of IL-3 correlates with occurrence and severity of Long-COVID

Following SARS-CoV-2 infection, some individuals develop Long-COVID-syndrome lasting for more than 3 months. We analyzed blood samples from patients w…

www.sciencedirect.com

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Adrienne Asher @asheradrienne.bsky.social · May 13

These findings suggest that Long COVID can cause hidden cardiopulmonary damage, and advanced imaging like PET/MRI and DECT may be key to detecting and managing long-term risks.
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jnm.snmjournals.org/content/earl...

Prevalence of Persistent Cardiovascular and Pulmonary Abnormalities on PET/MRI and DECT Imaging in Long COVID Patients

The objective of this study is to describe the prevalence of inflammatory cardiopulmonary findings in a prospective cohort of long coronavirus disease (LC) patients. Methods: Subjects with a history o...

jnm.snmjournals.org

Adrienne Asher @asheradrienne.bsky.social · May 13

Advanced imaging like PET/MRI and DECT revealed myocarditis, vascular inflammation, pulmonary infiltrates, and perfusion defects in a majority of patients. Blood tests also showed abnormal protein profiles linked to inflammation.
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Adrienne Asher @asheradrienne.bsky.social · May 13

A preprint study from Mount Sinai found that 57% of Respiratory Long COVID patients with ongoing shortness of breath showed signs of heart and lung inflammation nearly a year after infection, even when standard tests were normal.
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Adrienne Asher @asheradrienne.bsky.social · May 13

A systematic review/meta-analysis of nearly 140k participants found that excess weight is linked to increased risk of neurological symptoms in #LongCOVID. Fat tissue may serve as a reservoir for the virus, contributing to prolonged symptoms.

journals.plos.org/plosone/arti...

Excess weight is associated with neurological and neuropsychiatric symptoms in post-COVID-19 condition: A systematic review and meta-analysis

Background/purpose Excess weight has been identified as a potential risk factor for post-COVID-19 condition (PCC). This systematic review and meta-analysis aimed to investigate whether excess weight i...

journals.plos.org

Adrienne Asher @asheradrienne.bsky.social · May 13

The Schmidt Initiative for #LongCovid announced a clinical trial to test AstraZeneca’s monoclonal antibody Sipavibart as a treatment for Long COVID. The randomized, placebo-controlled trial builds on earlier reports of Long COVID remission after monoclonal antibody use.

silc.org/news/clinica...

Clinical trial underway for potential Long Covid treatment - Schmidt Initiative for Long Covid

A clinical trial is underway to assess the effectiveness and safety of sipavibart, AstraZeneca’s long-acting monoclonal antibody designed to provide protection against Covid-19, as a potential treatme...

silc.org

Adrienne Asher @asheradrienne.bsky.social · Apr 25

Key finding about cold exposure for #LongCovid: It’s not the temperature so much as how cold it *feels* to you.

Why Cold Exposure May Help with ME/CFS, Fibromyalgia and Long COVID - Health Rising

Cold exposure or cryotherapy may be able to help with the symptoms found in chronic fatigue syndrome, fibromyalgia and long COVID.

www.healthrising.org

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Adrienne Asher @asheradrienne.bsky.social · Apr 25

Pentadecanoic Acid (C15:0, aka Fatty15) and Its Potential Role in #LongCovid.

‎Gemini

Bard is now Gemini. Get help with writing, planning, learning, and more from Google AI.

gemini.google.com

Adrienne Asher @asheradrienne.bsky.social · Apr 23

According to the nutrition label, ASEA contains chloride (Cl) and sodium (Na). The active signaling molecules suspended in the saline solution are not listed. Do you know what they are?

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Adrienne Asher @asheradrienne.bsky.social · Apr 23

I’m sorry to read this. Take care.

Adrienne Asher @asheradrienne.bsky.social · Apr 23

Also looking forward to no longer seeing NaziBarbie at some point.

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Adrienne Asher @asheradrienne.bsky.social · Apr 23

Total agreement

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Adrienne Asher @asheradrienne.bsky.social · Apr 23

*white christo-fascist nation is what they’re trying to create, aka handmaid’s tale territory

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