Antonio Giordano MD PhD
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antgiordanomd.bsky.social
Antonio Giordano MD PhD
@antgiordanomd.bsky.social
240 followers 120 following 13 posts
Breast Medical Oncologist Dana-Farber Cancer Institute - Harvard Medical School - Boston
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Presented today the data from the Korean CSG BR 18-2 trial of ribociclib + trastuzumab + letrozole, first line chemo free regimen for HR+Her2+ MBC #ASCO25

ORR 61%
mPFS 30.4m
DOR 11.8m
Special look at toxicity (pruritus 24%, LFTs?)

Abstract 1016
Halls D2 3:15 PM May 30
#bcsm
Dose optimization of KAT6A inhibitor PA-07248144 will be presented today #ASCO25

Based on PK, tox, and activity (ORR 37%, cBR 56%, mPFS 10.7m), the 5 mg dose in combination with fulvestrant will move forward to RPh3 study in 2L HR+HER2- MBC @DFCI_BreastOnc

Hall D2 3:51 PM
Abstract 1020
#bcsm
Hope you had a safe flight. These curves are not convincing me…we need a statistician to comment. Unplanned retrospective analyses.
Reposted by Antonio Giordano MD PhD
Dr Kaelin gave a very thought provoking talk.

He argues single agent therapies will never cure cancer due to resistance.

Our chance is cure will come with multiple non-cross resistant therapies, challenging current paradigms.

#bcsm
Reposted by Antonio Giordano MD PhD
NEJM.org @nejm.org · Dec 11
The selective estrogen-receptor degrader imlunestrant plus abemaciclib led to a median progression-free survival of 9.4 months among patients with ER-positive, HER2-negative breast cancer (vs. 5.5 months with imlunestrant alone). Full EMBER-3 trial results: nej.md/4fZ74HX

#MedSky #SABCS24
BWEL intervention with diet and weight loss is able to improve:
✅metabolic biomarkers
✅insulin resistance
✅ stress biomarkers
BWEL study presented by Dr. Jennifer Ligibel. Looking forward to future data with improved breast cancer outcomes. @dfcibreastonc.bsky.social #SABCS24
Phase I clinical trials: it is important to get the dose as right as possible prior to phase III clinical trials. @fda.gov project OPTIMUS focus on totality of data for improved dose decision making:
- minimize toxicity
- enhance efficacy
- improve outcome for patients
#SABCS24 #clinicaltrials
Reposted by Antonio Giordano MD PhD
Make sure to follow @dfcibreastonc.bsky.social for updates on the latest research efforts by DFCI BOC and for periodic research digest with recent news in breast oncology! @stolaney1.bsky.social
Can we bring 2L PFS closer to 12 months post 1L CDK4/6i? More work needed to improve biomarkers for selection of optimal 2L therapeutic option. #ESMOASIA24
The largest oncology conference in Asia with over 4,000 participants is about to start. #ESMOAsia24 Singapore
Reposted by Antonio Giordano MD PhD
Only 3 weeks to #SABCS24, a meeting that promises to significantly impact the way we treat breast cancer. It will feature phase 3 data with novel SERDs, novel ADCs, immunotherapy, ctDNA monitoring, important biomarker analyses & so much more. Here’s my top 10 abstracts list— see you in San Antonio!
There is not enough evidence for poor performance of cdk4/6i (abema in MonarchE) in patients with BRCA pathogenic mutations. These patients still
deserve adj cdk4/6i if they meet criteria. Nadia Harbeck discussing this topic in Bogota 🇨🇴
When you open #bluesky and don’t see spaceX as your first feed 💙🦋 #oncsky relieved by H&E pathology slide @viveksubbiah.bsky.social
This looks very much like twitter in 2010! 😅 goodbye X