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ALK Positive Lung Cancer UK @alkpositiveuk.bsky.social · 2h

ALK+ is uncommon overall - it causes ~ 4% of lung cancers. But it appears far more often in younger people.

Studies show ALK rearrangements in more than 20% of those with #lungcancer under 40, & up to around 1/3 in small young-adult cohorts.

We have ALK+ UK members in their 20s & even teens. #LCSM

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Reposted by ALK Positive Lung Cancer UK

Lung Cancer Nursing UK @lcnuk.bsky.social · 1d

The new ALKnowledge site is live – an expert-led, interactive resource on ALK+ lung cancer for patients and professionals.

Visit now 🌐 alknowledge.org

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Reposted by ALK Positive Lung Cancer UK

Patient Information Forum @pifonline.bsky.social · 2d

Want to learn how to write in plain language? This is your last chance for an early bird discount on our training on writing health information.

For full details and to sign up, go to pifonline.org.uk/training-eve...
Book by 20 October to get 10% off.

#HealthInformation
#WritingHealthInformation

A mid-green background. At the top is a large green circle with the text: PIF training Writing health information 3-5 November 2025. Below it is a bright blue star with 10% off written in it. In the bottom right is an illustration of a woman leading a virtual event. In the bottom left text reads: Book by 20 October to claim early bird discount. Terms and conditions apply.

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Reposted by ALK Positive Lung Cancer UK

Arutha K @aruthak.bsky.social · 3d

Spatial signatures for predicting immunotherapy outcomes using multi-omics in non-small cell lung cancer www.nature.com/articles/s41... #SpatialMedicine #PrecisionMedicine #LungCancer @lungfoundation.bsky.social @iaslc.bsky.social

Spatial signatures for predicting immunotherapy outcomes using multi-omics in non-small cell lung cancer - Nature Genetics

This study uses spatial proteomic and spatial compartment-based whole-transcriptome profiling to develop predictive models for immunotherapy outcomes in non-small cell lung cancer.

www.nature.com

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Reposted by ALK Positive Lung Cancer UK

The Francis Crick Institute @crick.ac.uk · 5d

Crick researchers, in collaboration with Vividion Therapeutics, have developed a potential drug that blocks a key cancer growth signal, while still allowing healthy cell processes to continue.

The drug is currently undergoing its first clinical trial in humans.

www.crick.ac.uk/news/2025-10...

www.crick.ac.uk

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ALK Positive Lung Cancer UK @alkpositiveuk.bsky.social · 1d

🆕 NHS England Blueteq criteria published for 1L lorlatinib in ALK+ #lungcancer - approved by NICE on 7 Oct.

Dr Riyaz Shah: “very permissive & great for patients” - allowing early TKI switching within 6 months if toxicity occurs.

Big progress in access & flexibility for people with ALK+.

#LCSM

Screenshot of a post by Dr Riyaz Shah. He writes that Blueteq forms for all first-line ALK+ lung cancer inhibitors have been adjusted to allow switching for toxicity within the first six months. He jokes that the form even allows switching if intolerant to brigatinib, and adds that overall the new criteria are very permissive and great for patients. Two Blueteq form screenshots are shown below the text.

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Reposted by ALK Positive Lung Cancer UK

All You Need is Lungs @allyouneedislungs.bsky.social · 1d

Polly, 64, was diagnosed with stage 4 EGFR+ #lungcancer in 2021.

Gardening, knitting, & time with family & friends help her stay positive and enjoy the simple things in life. 🌿

She’s one of over 30 voices in our 2025 All You Need Is Lungs campaign for Lung Cancer Awareness Month.

#LCSM

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Reposted by ALK Positive Lung Cancer UK

ESMO - European Society for Medical Oncology @myesmo.bsky.social · 2d

🤖 How can AI streamline and reshape the clinical trial process?
Find out in the session “Clinical trials for AI and AI for clinical trials” at #ESMOAI25 in Berlin.
👉 www.esmo.org/meeting-cale...

#DigitalOncology #AIOncology #HealthAI

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ALK Positive Lung Cancer UK @alkpositiveuk.bsky.social · 2d

A single blood test could detect 50+ cancers - including #LungCancer.

New #ESMO2025 data suggest stronger performance than earlier trials – possibly detecting more than 50% of true cases.

The NHS Galleri trial with 140K people will show what this means for cancers like ALK+.

#ALKPositive #LCSM

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ALK Positive Lung Cancer UK @alkpositiveuk.bsky.social · 3d

New Case report: SMARCA4-deficient NSCLC with ALK fusion.

Applied Immunohistochemistry & Molecular Morphology describes a rare & interesting case - a non-smoking woman with non-small cell #lungcancer that was SMARCA4-deficient, yet still harboured an ALK fusion.

#ALKPositive #LCSM

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ALK Positive Lung Cancer UK @alkpositiveuk.bsky.social · 5d

Great to see our Chair Debra Montague quoted in coverage of NICE’s decision recommending lorlatinib as a 1L trtmt for people newly diagnosed with ALK+ #lungcancer in England & Wales.

A real step forward in access to targeted treatments on the NHS & recognition of the UK ALK+ community.

#LCSM

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ALK Positive Lung Cancer UK @alkpositiveuk.bsky.social · 5d

🆕 case report describes a woman with advanced #ALK+ #lungcancer who became pregnant on lorlatinib. Trtmt was paused then restarted. Baby was born healthy at 32 wks & is thriving at 20 mnths - the 1st published case showing a successful outcome. #LCSM

jto.org/article/S1556-0864(25)00746-4/fulltext

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Reposted by ALK Positive Lung Cancer UK

BTOG @btog.bsky.social · 6d

💡 Discover the latest in mutation-driven lung cancer research.
Session 4 with @ruthstraussfdn.bsky.social rings science, debate, and progress together.
📅 13 Nov | 📍 The View, London
🔗 www.btog.org/non-smo...
#LungCancer #LCSM #NonSmokingLungCancer

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Reposted by ALK Positive Lung Cancer UK

Lung Foundation Australia @lungfoundation.bsky.social · 5d

Is your job harming your lungs? 👷🫁

Take the healthy lungs at work quiz to assess your risk: buff.ly/ofeS9u0

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Reposted by ALK Positive Lung Cancer UK

Patient Information Forum @pifonline.bsky.social · 6d

If you want information you can trust on women's health or cancer, we have a collection of resources on our PIF TICK website.
All the resources are created by Trusted Information Creators using a PIF TICK approved process.
Take a look here: piftick.org.uk/resource-col...
#BreastCancerAwarenessMonth

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Reposted by ALK Positive Lung Cancer UK

Lung Cancer Nursing UK @lcnuk.bsky.social · 7d

We’re looking for new Trustees to join LCNUK, including a Finance Trustee.

Help us strengthen lung cancer nursing and patient care nationwide.

Learn more and apply ▶️ ow.ly/M57150X3eME

Application deadline: 7th October.

#Trustee #Governance

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Reposted by ALK Positive Lung Cancer UK

Nature @nature.com · 6d

An AI tool that scans manuscript titles and abstracts has flagged more than 250,000 cancer studies that bear textual similarities to articles that are known to have been produced by paper mills

go.nature.com/48mbbgj

Low quality papers are flooding the cancer literature — can this AI tool help to catch them?

A large language model scans abstracts and titles for signs that an article was produced by a 'paper-mill' company.

go.nature.com

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Reposted by ALK Positive Lung Cancer UK

Nature @nature.com · 6d

Analyses of RNA expression reveal molecules underpinning the cancer-associated process of skeletal-muscle wasting

go.nature.com/4gZI2Kh

Clues to why the weight-loss condition cachexia arises when cancer occurs

Analyses of RNA expression reveal molecules underpinning the cancer-associated process of skeletal-muscle wasting, a condition called cachexia.

go.nature.com

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Reposted by ALK Positive Lung Cancer UK

The King's Fund @thekingsfund.bsky.social · 6d

The latest #NHS performance data shows while there have been slight improvements in patient experience surveys, wider efforts to tackle waiting lists remain shaky. Read our full response 🔽 https://bit.ly/42y9bOj

Latest NHS Performance Stats Show Green Shoots Of NHS Recover Remain Fragile | The King's Fund

Danielle Jefferies, Senior Analyst at The King's Fund, responds to the latest monthly NHS performance data.

bit.ly

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Reposted by ALK Positive Lung Cancer UK

All You Need is Lungs @allyouneedislungs.bsky.social · 7d

It’s a pinch me moment! All You Need Is Lungs is a finalist tonight at the UK Social Media Awards for Best Charity/Non-Profit Campaign 🎉

Our little team is heading there with some of the amazing voices behind this #LungCancer awareness campaign & thinking of those who are no longer with us.

#LCSM

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ALK Positive Lung Cancer UK @alkpositiveuk.bsky.social · 7d

Today’s NICE decision marks a big step forward for people newly diagnosed with ALK-positive #lungcancer.

Our full statement explains what it means in practice - and why we’ll keep pushing for earlier testing and access.

🔗 www.alkpositive.org.uk/_files/ugd/3...

💙 #LCSM

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ALK Positive Lung Cancer UK @alkpositiveuk.bsky.social · 8d

‼️ BIG NEWS for ALK+!

NICE has today recommended lorlatinib (Lorbrena) as the first treatment for people in England & Wales newly diagnosed with advanced ALK+ #lungcancer.

Access to the best option from day one matters - this is real progress for people newly diagnosed & starting treatment.

#LCSM

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ALK Positive Lung Cancer UK @alkpositiveuk.bsky.social · 9d

For ALK+ lung cancer, this helps explain why immunotherapy hasn’t yet delivered the same benefit we see in other cancers. Research like this is so key for finding what could change that.

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ALK Positive Lung Cancer UK @alkpositiveuk.bsky.social · 9d

“9 yrs since my #lungcancer diagnosis” - Debra Montague, ALK+ UK Chair & Founder.

3× longer than the life expectancy I was given. Grateful for every ‘extra year’ & everything it brings: family, friends, advocacy, travel, music & memories. Still saying yes to life & excited for what’s next. 💙 #LCSM

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ALK Positive Lung Cancer UK @alkpositiveuk.bsky.social · 10d

Prof Sanjay Popat shared an encouraging outlook on ALK+ #lungcancer treatments at our conference last weekend.

Huge thanks to him and to all our experts - we couldn’t make this conference happen every year without you. It’s so important that our community stays informed & empowered. 💙 #LCSM

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