Author | Lightnews

Augusto Cesar S Santos Jr @acssjr.bsky.social · 11d

Check at @transplantation.bsky.social

The bioinformatic tool HLA-EP-RESOLVER accurately predicts antibody reactivity to rare HLA alleles using eplet analysis.

tinyurl.com/2m9nm6ek

#Transplantation #High #Resolution #HLA

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Reposted by Augusto Cesar S Santos Jr

transplantation.bsky.social @transplantation.bsky.social · 14d

The bioinformatic tool HLA-EP-RESOLVER accurately predicts antibody reactivity to rare HLA alleles using eplet analysis. Validated in sensitized patients, it helps identify acceptable/unacceptable antigens in the era of high-resolution donor typing. #HLA tinyurl.com/2m9nm6ek

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Augusto Cesar S Santos Jr @acssjr.bsky.social · Sep 16

World Kidney Day 2026 starts now!
Participate!

Caring for people, protecting the planet!
#KidneyHealthMatters
#CheckYourCreatinine

ISNkidneycare @theisn.org · Sep 15

📣 We’re thrilled for the launch of the World Kidney Day 2026 campaign! We’re loving the new campaign image!

Discover the 2026 theme here 👉 www.worldkidneyday.o...
#WorldKidneyDay #OurKidneysOurPlanet #KidneyHealthForAll

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Augusto Cesar S Santos Jr @acssjr.bsky.social · Aug 15

Just 1 month to go until the 2026 #WKD campaign officially kicks off!

Stay tuned for updates. Get ready to join us in this movement for kidney health!

Follow the @worldkidneyday site and social media pages!
www.worldkidneyday.org

@theisn.org IFKF #KidneyHealthMatters

Homepage - World Kidney Day 2025

World Kidney DayRaising awareness of theimportance of our kidneysWho we areWKD 2025 Scientific EditorialAre Your Kidneys Ok?Detect early to protect kidney healthRead the 2025 Scientific EditorialKidne...

www.worldkidneyday.org

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Augusto Cesar S Santos Jr @acssjr.bsky.social · Aug 2

I’m thrilled to see the Graphical Abstract Video Presentations now featured on the KIR website!

www.kireports.org/video-do

I’m deeply grateful to everyone who contributed to making this #vision a reality!
@theisn.org @kidneyint.bsky.social @kireports.bsky.social

#ThisIsISN #KidneyHealthMatters

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Reposted by Augusto Cesar S Santos Jr

Brammah R Thangarajah @kidneying.bsky.social · Jul 31

#ECNeph @brammahin.@myadla. @Dilushiwijay
@dra_miliflore @acssjr

Similar presentation in Post Tx Pt

But ..why is it so rare ?
Why dont we see it often despite high use ?

Thoughts ?

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Augusto Cesar S Santos Jr @acssjr.bsky.social · Jul 31

Thanks @kidneying.bsky.social ! Exceptional case #ECNeph!

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Reposted by Augusto Cesar S Santos Jr

Brammah R Thangarajah @kidneying.bsky.social · Jul 31

Proposed mechanism of hyperinflammation due to MMF
#ECNeph @brammahin @myadla @Dilushiwijay @dra_miliflores
@acssjr.bsky.social

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Reposted by Augusto Cesar S Santos Jr

Brammah R Thangarajah @kidneying.bsky.social · Jul 31

#ECNeph @brammahin @Dilushiwijay @myadla @acssjr @dra_miliflores

⚠️ Few warnings exist already

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Reposted by Augusto Cesar S Santos Jr

Brammah R Thangarajah @kidneying.bsky.social · Jul 31

When you suspect MMF-hyperinflammation
dont forget to exclude these
#ECNeph @brammahin @myadla @Dilushiwijay
@dra_miliflores
@acssjr.bsky.social

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Reposted by Augusto Cesar S Santos Jr

Brammah R Thangarajah @kidneying.bsky.social · Jul 31

#ECNeph @brammahin @Dilushiwijay @myadla @acssjr @dra_miliflores

pubmed.ncbi.nlm.nih....
pubmed.ncbi.nlm.nih....

☄️ More than few reported cases exist

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Reposted by Augusto Cesar S Santos Jr

Brammah R Thangarajah @kidneying.bsky.social · Jul 31

Differentiating fever from flare in lupus
#ECNeph @brammahin @myadla @Dilushiwijay
@dra_miliflores @acssjr

NLR
CRP/ESR ratio <2/2-15/>15 : <2 s/o infection

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Reposted by Augusto Cesar S Santos Jr

Brammah R Thangarajah @kidneying.bsky.social · Jul 31

💥 Could this be MAS in SLE? We are seeing it more often,

🗝️ - Clues in clinical practice
Fever
Pancytopenia
Organomegaly
⬇️ ESR with disease activity

#ECNeph @brammahin @Dilushiwijay @myadla @acssjr @dra_miliflores

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Reposted by Augusto Cesar S Santos Jr

Brammah R Thangarajah @kidneying.bsky.social · Jul 31

ℹ️Turns out patient has hypogammaglobulinemia
❓MMF related/disease related
Ig A - 134 mg/dl ( 70-400)
⬇️Ig G - 669 mg/dL (700-1600)
⬇️⬇️Ig M - 38 mg/dL (40-230)

😏Does it explain all?

#ECNeph @brammahin @Dilushiwijay @myadla @acssjr @dra_miliflores

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Reposted by Augusto Cesar S Santos Jr

Brammah R Thangarajah @kidneying.bsky.social · Jul 31

#ECNeph @brammahin @myadla @Dilushiwijay
@acssjr @dra_miliflores
#ECNeph

Do you agree ?

Post your final diagnosis ....

Is it to do with IST ?

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Augusto Cesar S Santos Jr @acssjr.bsky.social · Jul 31

Maybe this could be our way to go!
#ECNeph

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Reposted by Augusto Cesar S Santos Jr

Brammah R Thangarajah @kidneying.bsky.social · Jul 31

🦠 When do you think fever is of infection in origin?

⁉️ Can we rule out all infections all the times? Say some hidden TB or a very timid virus. We need more markers.

#ECNeph @brammahin @Dilushiwijay @myadla @acssjr
@dra_miliflores

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Reposted by Augusto Cesar S Santos Jr

Brammah R Thangarajah @kidneying.bsky.social · Jul 31

#ECNeph @brammahin @myadla @Dilushiwijay
@acssjr @dra_miliflores
#ECNeph
yet another admission ..in a weeks time
premature discharge vs recurrence of infection /appearance of flare

High inflammatory markers favour infection
or is it non infectious inflammation

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Reposted by Augusto Cesar S Santos Jr

Brammah R Thangarajah @kidneying.bsky.social · Jul 31

#ECNeph @brammahin @myadla @Dilushiwijay
@acssjr @dra_miliflores
#ECNeph

see the time line of admissions for febrile episodes
Class switch
High inflammatory markers
Infection clues negative
3 episodes in 2-3 months

Where should this lead to ?

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Reposted by Augusto Cesar S Santos Jr

Brammah R Thangarajah @kidneying.bsky.social · Jul 31

🔂 3 admissions with acute febrile illnesses within
2-month span
🩺 No focal signs/symptoms
☢️ Routine imaging -negative -No organ-specific
illness
#ECNeph @brammahin @Dilushiwijay @myadla @acssjr @dra_miliflores

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Reposted by Augusto Cesar S Santos Jr

Brammah R Thangarajah @kidneying.bsky.social · Jul 31

#ECNeph @brammahin @myadla @Dilushiwijay
@acssjr @dra_miliflores
#ECNeph
Rx with antibiotics
Restarted on IST after fever subsidence

What next ?
Evaluation being negative for all infections : Bacteria /virus ..
How to go further ?

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Reposted by Augusto Cesar S Santos Jr

Brammah R Thangarajah @kidneying.bsky.social · Jul 31

⚓️ What features would suggest SLE activity for you?

⚖️ Do you weigh on global assessment?

#ECNeph @brammahin @Dilushiwijay @myadla @acssjr @dra_miliflores

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Reposted by Augusto Cesar S Santos Jr

Brammah R Thangarajah @kidneying.bsky.social · Jul 31

#ECNeph @brammahin @myadla @ISNkidneycare
@Dilushiwijay @acssjr @dra_miliflores

ESR:CRP <2
S/O infection than flare
Lupus. 2018 Jun;27(7):1123-1129

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Reposted by Augusto Cesar S Santos Jr

Brammah R Thangarajah @kidneying.bsky.social · Jul 31

#ECNeph @brammahin @myadla @ISNkidneycare @Dilushiwijay @acssjr @dra_miliflores

Does the evaluation suggest flare ?
All atypical infections ruled out
Malignancy ??????
What else ?
PET-CT ?

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Reposted by Augusto Cesar S Santos Jr

Brammah R Thangarajah @kidneying.bsky.social · Jul 31

🗣️Fever in SLE - An enigma wrapped in mystery.

Interested in hearing your phrases of fever and also how do you define it in routine practice?

🧈 Just basics
#ECNeph @brammahin @Dilushiwijay @myadla @acssjr @dra_miliflores

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