Yi Zhou

Reposted by Yi Zhou

Michael Totty @mictott.bsky.social · 28d

Very excited to share my second postdoc, now out in Science Advances! We used targeted snRNA-seq to profile four major subnuclei of the primate across three species (including humans). 1/13 www.science.org/doi/10.1126/...

Transcriptomic diversity of amygdalar subdivisions across humans and nonhuman primates

Specialized cell types and links to psychiatric disorders are revealed by genetic mapping of primate amygdala neurons.

www.science.org

3 16 35

Reposted by Yi Zhou

Camp Lab @graycamplab.bsky.social · Aug 22

Final version @science.org "Recent evolution of the developing human intestine affects metabolic and barrier functions". Evolutionary preparation for microbiota, diet, and pathogen exposure is fascinating! Thank you @erc.europa.eu for supporting our vision!
www.science.org/doi/10.1126/...

2 8 29

Reposted by Yi Zhou

Nature Neuroscience @natneuro.nature.com · Aug 22

Cross-species analysis of adult hippocampal neurogenesis reveals human-specific gene expression but convergent biological processes

@zhoujoeyyi.bsky.social

www.nature.com/articles/s41...

Cross-species analysis of adult hippocampal neurogenesis reveals human-specific gene expression but convergent biological processes - Nature Neuroscience

Machine-learning-augmented single-nucleus transcriptomic analysis compared molecular landscapes of immature neurons in the mammalian hippocampus across species, highlighting human-specific gene expres...

www.nature.com

2 6

by Yi Zhou

Yi "Joey" Zhou @zhoujoeyyi.bsky.social · Aug 11

Thank you for the insightful feedback during our last meeting—truly appreciated!

1 2

by Yi Zhou

Yi "Joey" Zhou @zhoujoeyyi.bsky.social · Aug 11

Full text available at rdcu.be/eAcNN

Cross-species analysis of adult hippocampal neurogenesis reveals human-specific gene expression but convergent biological processes

Nature Neuroscience - Machine-learning-augmented single-nucleus transcriptomic analysis compared molecular landscapes of immature neurons in the mammalian hippocampus across species, highlighting...

rdcu.be

1

by Yi Zhou

Yi "Joey" Zhou @zhoujoeyyi.bsky.social · Aug 11

Excited to share our study published in @natneuro.nature.com today! We conducted cross-species analyses of immature neurons arising from adult hippocampal neurogenesis, revealing distinct human-specific gene expression patterns but convergent biological processes. www.nature.com/articles/s41...

Cross-species analysis of adult hippocampal neurogenesis reveals human-specific gene expression but convergent biological processes - Nature Neuroscience

Machine-learning-augmented single-nucleus transcriptomic analysis compared molecular landscapes of immature neurons in the mammalian hippocampus across species, highlighting human-specific gene expres...

www.nature.com

2 3

by Yi Zhou

Yi "Joey" Zhou @zhoujoeyyi.bsky.social · May 20

Congratulations Xuyu!

2

by Yi Zhou

Yi "Joey" Zhou @zhoujoeyyi.bsky.social · May 15

Great work in @nature.com by @qianxuyu.bsky.social from Dr. Chris Walsh lab revealing early specification of the human cortex using spatial omics. Congratulations Xuyu!🎊🎉

Xuyu Qian @qianxuyu.bsky.social · May 14

Today in @nature.com , we report a spatial single-cell atlas of human cortical development, revealing surprisingly early specification of human cortical layers and areas.
We built an interactive browser to explore the spatial data: walshlab.org/research/cor...
Paper link below 👇

5

Reposted by Yi Zhou

Xuyu Qian @qianxuyu.bsky.social · May 14

Today in @nature.com , we report a spatial single-cell atlas of human cortical development, revealing surprisingly early specification of human cortical layers and areas.
We built an interactive browser to explore the spatial data: walshlab.org/research/cor...
Paper link below 👇

5 39 96

by Yi Zhou

Yi "Joey" Zhou @zhoujoeyyi.bsky.social · Mar 28

A new study in preprint from @amarsahay.bsky.social lab shows that prolonged maturation of adult-born hippocampal neurons affects hippocampal network by strengthening inhibitory brain circuitry. doi.org/10.21203/rs....

Neotenic expansion of adult-born dentate granule cells reconfigures GABAergic inhibition to enhance social memory consolidation

Adult-born dentate granule cells (abDGCs) contribute to hippocampal dentate gyrus (DG)-CA3/CA2 circuit functions in memory encoding, retrieval and consolidation. Heightened synaptic and structural pla...

doi.org

2

by Yi Zhou

Yi "Joey" Zhou @zhoujoeyyi.bsky.social · Mar 7

Thank you Giorgia!!

Reposted by Yi Zhou

Esther Klingler @estherkli.bsky.social · Feb 20

✨ We tend to think of species-specific differences as resulting from the presence of species-specific genes. In our latest work with @djabaudon.bsky.social, we show that building brains is not only about which genes you use, but also about when and where you do.
www.biorxiv.org/content/10.1...

6 27 73

by Yi Zhou

Yi "Joey" Zhou @zhoujoeyyi.bsky.social · Feb 19

❤️

by Yi Zhou

Yi "Joey" Zhou @zhoujoeyyi.bsky.social · Feb 19

Thank you, Dr. Boeckx, for highlighting our work ! It’s exciting to see the convergence of our findings, which suggest that lysosome function in neuronal development evolves across species in a spatiotemporal- and cell type-dependent manner, with human lysosomes playing unique roles.

Cedric Boeckx @cedricboeckx.bsky.social · Feb 18

I was struck by the importance of lysosomes in characterizing these human-specific features, @zhoujoeyyi.bsky.social;
this finding links well with our recent work on this pathway, CHD2 and 🧠 maturation (ping @naelnadifkasri-lab.bsky.social @ellylewerissa.bsky.social @olivieroleonardi.bsky.social)

www.biorxiv.org

1 1 2

by Yi Zhou

Yi "Joey" Zhou @zhoujoeyyi.bsky.social · Feb 19

Check out our latest preprint, where we cross-compared the molecular landscapes of immature neurons in the hippocampus in different mammalian species👨🐵🐷🐭, revealing specialized features in humans. www.biorxiv.org/content/10.1...

Comparative molecular landscapes of immature neurons in the mammalian dentate gyrus across species reveal special features in humans

Immature dentate granule cells (imGCs) arising from adult hippocampal neurogenesis contribute to plasticity, learning and memory, but their evolutionary changes across species and specialized features...

www.biorxiv.org

1 3 10

Reposted by Yi Zhou

Cedric Boeckx @cedricboeckx.bsky.social · Feb 18

I was struck by the importance of lysosomes in characterizing these human-specific features, @zhoujoeyyi.bsky.social;
this finding links well with our recent work on this pathway, CHD2 and 🧠 maturation (ping @naelnadifkasri-lab.bsky.social @ellylewerissa.bsky.social @olivieroleonardi.bsky.social)

www.biorxiv.org

1 2

References

Fields & subjects