4) What's the cause of all of this? The team thinks there's a breakdown of purinergic signaling that prevents ME/CFS cells from shutting down and resolving inflammation properly – similar to Bob Naviaux’s theory.
October 21, 2025 at 8:24 AM
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P2RY2 is a purinergic immune checkpoint linking extracellular ATP to immune evasion and adaptive resistance to immunotherapy @biorxivpreprint.bsky.social
www.biorxiv.org/content/10.1... @uniheidelberg.bsky.social
www.biorxiv.org/content/10.1... @uniheidelberg.bsky.social
October 12, 2025 at 2:30 AM
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#genetexinc extends its collection of #recombinant monoclonal #antibodies against G-Protein Coupled Receptors #GPCR with the Purinergic P2Y receptors P2Y1,-2,-4,-6,-11,-12,-13,-14R
🔗https://www.stratech.co.uk/catalogue/?query=P2Y1&manufacturer=242
#neurotransmission #neurodegeneration #autoimmune
🔗https://www.stratech.co.uk/catalogue/?query=P2Y1&manufacturer=242
#neurotransmission #neurodegeneration #autoimmune
April 16, 2025 at 12:01 PM
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Altered Purinergic Signaling and CD8+ T Cell Dysregulation in STAT3 GOF Syndrome #SingleCell 🧪🧬🖥️
http://biorxiv.org/cgi/content/short/2024.12.12.626682v1
http://biorxiv.org/cgi/content/short/2024.12.12.626682v1
December 14, 2024 at 1:08 PM
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There is a new PhD in town. 👏
Congratulations Dr. Mata-Salgado, zorionak Paloma!!
P2X4 purinergic receptor-based therapeutic strategies for experimental Multiple Sclerosis. #MS
Congratulations Dr. Mata-Salgado, zorionak Paloma!!
P2X4 purinergic receptor-based therapeutic strategies for experimental Multiple Sclerosis. #MS
July 22, 2025 at 8:21 AM
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Enhanced purinergic signaling in the paraventricular hypothalamus induces hyperphagic obesity and insulin resistance https://www.biorxiv.org/content/10.1101/2024.07.02.601503v1
Enhanced purinergic signaling in the paraventricular hypothalamus induces hyperphagic obesity and insulin resistance https://www.biorxiv.org/content/10.1101/2024.07.02.601503v1
Body energy homeostasis is tightly regulated by hypothalamic neural circuits. However, their remodel
www.biorxiv.org
July 3, 2024 at 10:16 AM
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We thank the organizers of the PRESTO COST action meeting (Dublin, Ireland, 22-24/05), on the topic "Purinergic signalling: from bench-to-bedside, where are we now?"
Congratulations to our unit members W. ECHCHIH, M. PICHONNIERE, M. ElMALLAH, A. HERAUD-MELEY and O. BENOUNA for their presentations.
Congratulations to our unit members W. ECHCHIH, M. PICHONNIERE, M. ElMALLAH, A. HERAUD-MELEY and O. BENOUNA for their presentations.
May 26, 2025 at 2:17 PM
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Join us TODAY at 3pm for a Radiotherapy and Radiobiology focussed seminar:
Dr Erik Wennerberg: Harnessing purinergic signalling to counteract cancer immune resistance
Prof Kenneth Long: The Laser-hybrid Accelerator for Radiobiological Applications
📅 TODAY, 3rd April, 3-4pm
🖱️ bit.ly/4ljsrHa
Dr Erik Wennerberg: Harnessing purinergic signalling to counteract cancer immune resistance
Prof Kenneth Long: The Laser-hybrid Accelerator for Radiobiological Applications
📅 TODAY, 3rd April, 3-4pm
🖱️ bit.ly/4ljsrHa
April 3, 2025 at 10:05 AM
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📢 Scientific Program Now Live | #FPC2025
From purinergic checkpoints in cancer to ATP signaling in neurodegeneration, the 3rd Scientific Days of the French Purine Club bring cutting-edge talks across immunology, oncology & neuroscience.
📍June 30–July 1 | ESPCI Paris
From purinergic checkpoints in cancer to ATP signaling in neurodegeneration, the 3rd Scientific Days of the French Purine Club bring cutting-edge talks across immunology, oncology & neuroscience.
📍June 30–July 1 | ESPCI Paris
June 29, 2025 at 7:36 PM
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Supracellular contractility in Xenopus laevis embryonic epithelia regulated by extracellular nucleotides and the purinergic G-protein coupled receptor P2Y2. https://www.biorxiv.org/content/10.1101/2025.01.21.634176v1
January 23, 2025 at 10:34 AM
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#medsky🧪 #immunosky #neurosky #publichealth An emerging body of research implicating #SleepLoss as a #metabolicdisorder and discuss its impact on the metabolism of neurons and parallels to #neurodegenerativedisorders.
www.science.org/doi/10.1126/... @science.org
www.science.org/doi/10.1126/... @science.org
April 16, 2025 at 6:31 AM
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Fluid shear stress promotes glial-mediated neurotoxicity in vitro via purinergic signaling https://www.biorxiv.org/content/10.1101/2025.04.29.651240v1
May 4, 2025 at 2:46 AM
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Thomas Grutter (Université de Strasbourg)
"New labeling method for revealing endogenous P2X7 at single-molecule level in BV2 microglia"
🔍 Cutting-edge imaging meets purinergic biology.
#FPC2025 #Neuroimaging #P2X7 #SingleMolecule
"New labeling method for revealing endogenous P2X7 at single-molecule level in BV2 microglia"
🔍 Cutting-edge imaging meets purinergic biology.
#FPC2025 #Neuroimaging #P2X7 #SingleMolecule
June 30, 2025 at 1:30 PM
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P2RY2 is a purinergic immune checkpoint linking extracellular ATP to immune evasion and adaptive resistance to immunotherapy https://www.biorxiv.org/content/10.1101/2025.10.09.681049v1
October 10, 2025 at 8:16 PM
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RRID:IMSR_JAX:000664 was used by the authors of the ACS Chemical Neuroscience paper "Purinergic Receptor P2Y1 Modulates Catecholamine Signaling in Murine Mesenteric Lymph Nodes". Thank you for making your methods matter! #reproducibility #RRID
doi.org
March 28, 2025 at 7:00 AM
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📃Scientific paper: Hindbrain Adenosine 5-Triphosphate (ATP)-Purinergic Signaling Triggers LH Surge and Ovulation via Ac...
➡️ Continued on ES/IODE
➡️ Continued on ES/IODE
July 3, 2024 at 1:16 PM
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Purinergic signalling and calcium dynamics: potential drivers in the onset of coordinated intestinal motility in human fetal development https://www.biorxiv.org/content/10.1101/2025.04.17.649306v1
April 20, 2025 at 3:30 AM
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Interesting and accessible essay for anyone interested in cough & pulmonary science
Describes how airway neuroendocrine cells monitor aspiration and trigger pulmonary reflexes via purinergic signals
www.science.org/doi/10.1126/...
Describes how airway neuroendocrine cells monitor aspiration and trigger pulmonary reflexes via purinergic signals
www.science.org/doi/10.1126/...
(Don’t) take my breath away: Rare epithelial cells in our airways initiate reflexes to guard against harmful stimuli
Rare epithelial cells in our airways initiate reflexes to guard against harmful stimuli
www.science.org
September 29, 2024 at 7:57 AM
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Altered Purinergic Signaling and CD8+ T Cell Dysregulation in STAT3 GOF Syndrome https://www.biorxiv.org/content/10.1101/2024.12.12.626682v1
December 14, 2024 at 10:16 AM
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Selective regulation of IFN-γ and IL-4 co-producing unconventional T cells by purinergic signalling https://www.biorxiv.org/content/10.1101/2024.08.11.607476v1
Selective regulation of IFN-γ and IL-4 co-producing unconventional T cells by purinergic signalling https://www.biorxiv.org/content/10.1101/2024.08.11.607476v1
Unconventional T cells, including mucosal-associated invariant T (MAIT), natural killer T (NKT), and
www.biorxiv.org
August 12, 2024 at 2:15 AM
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Norepinephrine changes behavioral state via astroglial purinergic signaling https://www.biorxiv.org/content/10.1101/2024.05.23.595576v1
Norepinephrine changes behavioral state via astroglial purinergic signaling https://www.biorxiv.org/content/10.1101/2024.05.23.595576v1
Both neurons and glia communicate via diffusible neuromodulatory substances, but the substrates of c
www.biorxiv.org
May 24, 2024 at 1:17 AM
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Find out about the next PRESTO meeting hosted in Ireland, from the organiser Dr Tobias Engel (Royal College of Surgeons Ireland) link here: ➡️ m.youtube.com/watch?v=tQxp... #Presto #p2x #purinergic #benchtobedside
PRESTO Dr Tobias Engel (Royal College of Surgeons, Ireland) interview
YouTube video by PrestoCost Comms
m.youtube.com
March 19, 2025 at 3:01 PM
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Purinergic receptor activation rectifies autism-associated endothelial dysfunction https://www.biorxiv.org/content/10.1101/2025.06.02.657522v1
June 3, 2025 at 8:30 AM
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Purinergic receptor P2X7 regulates interleukin-1α mediated inflammation in chronic kidney disease in a reactive oxygen species-dependent manner🔓
www.kidney-international.org/article/S008...
www.kidney-international.org/article/S008...
Purinergic receptor P2X7 regulates interleukin-1α mediated inflammation in chronic kidney disease in a reactive oxygen species-dependent manner
Onset, progression and cardiovascular outcome of chronic kidney disease (CKD) are
influenced by the concomitant sterile inflammation. The pro-inflammatory cytokine
family interleukin (IL)-1 is crucial...
www.kidney-international.org
March 31, 2025 at 5:10 PM
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Norepinephrine changes behavioral state through astroglial purinergic signaling
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Norepinephrine changes behavioral state through astroglial purinergic signaling
Both neurons and glia communicate through diffusible neuromodulators; however, how neuron-glial interactions in such neuromodulatory networks influence circuit computation and behavior is unclear. Dur...
www.science.org
May 15, 2025 at 8:27 PM
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