Zane Lybrand
@zane-of-science.bsky.social
Assistant prof @TWU
Building neural systems to understand brain trauma
LybrandLab.org
Building neural systems to understand brain trauma
LybrandLab.org
Myles gave his Biology Seminar talk on stem cell derived cortical graft for brain repair.
April 11, 2025 at 9:49 PM
Myles gave his Biology Seminar talk on stem cell derived cortical graft for brain repair.
I will stop whatever I'm doing anytime a student excitedly knocks on my door to show me new data.
April 10, 2025 at 9:35 PM
I will stop whatever I'm doing anytime a student excitedly knocks on my door to show me new data.
Reposted by Zane Lybrand
NIH Funds remain frozen using a loophole to try to circumvent judge's orders. Call your elected representatives including Governor and state AG (or DC AG). Express your concern that this will hurt the economy, livelihood, &long-term health of constituents
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Revealed: NIH research grants still frozen despite lawsuits challenging Trump order
The Trump administration is exploiting a loophole to keep a funding freeze in place, leaving researchers in limbo.
www.nature.com
February 21, 2025 at 12:01 AM
NIH Funds remain frozen using a loophole to try to circumvent judge's orders. Call your elected representatives including Governor and state AG (or DC AG). Express your concern that this will hurt the economy, livelihood, &long-term health of constituents
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Reposted by Zane Lybrand
Helpful table to determine how much your University or health system is set to lose if the NIH indirect cap is suddenly lowered to 15%. For SJSU it is $374k which is on the smaller end but devastating considering our other budget issues. datawrapper.dwcdn.net/l0ZqA/8/
Estimated Single Year Loss of NIH Funding if 15% Indirect Cost Rate is Imposed
Based on analysis of 2024 NIH funding data. Sums are totals of losses in funding to programs if indirect costs had been capped at 15%
datawrapper.dwcdn.net
February 9, 2025 at 4:24 PM
Helpful table to determine how much your University or health system is set to lose if the NIH indirect cap is suddenly lowered to 15%. For SJSU it is $374k which is on the smaller end but devastating considering our other budget issues. datawrapper.dwcdn.net/l0ZqA/8/
The economic impact on North Texas due to the 15% F&A cap is thousands of jobs lost, over $500M in annual economic activity gone, and delays to life-saving research on diseases like cancer and Alzheimer’s.
Read my letter to Congress and report here:
Read my letter to Congress and report here:
February 9, 2025 at 1:09 PM
The economic impact on North Texas due to the 15% F&A cap is thousands of jobs lost, over $500M in annual economic activity gone, and delays to life-saving research on diseases like cancer and Alzheimer’s.
Read my letter to Congress and report here:
Read my letter to Congress and report here:
Reposted by Zane Lybrand
1. Today the NIH director issued a new directive slashing overhead rates to 15%.
I want to provide some context on what that means and why it matters.
grants.nih.gov/grants/guide...
I want to provide some context on what that means and why it matters.
grants.nih.gov/grants/guide...
NOT-OD-25-068: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates NOT-OD-25-068. OD
grants.nih.gov
February 8, 2025 at 12:18 AM
1. Today the NIH director issued a new directive slashing overhead rates to 15%.
I want to provide some context on what that means and why it matters.
grants.nih.gov/grants/guide...
I want to provide some context on what that means and why it matters.
grants.nih.gov/grants/guide...
Fascinated by how the brain networks balance flexibility and stability. Stochastic ensembles in the dlPFC show that transient, dynamic neuron networks can produce reliable population-level representations. A key to understanding cognitive flexibility and resilience!
www.cell.com/current-biol...
www.cell.com/current-biol...
Recurrent activity propagates through labile ensembles in macaque dorsolateral prefrontal microcircuits
Using ex vivo Ca2+ imaging in macaque dorsolateral prefrontal cortex, Nolan et al. reveal that recurrent activity propagates through unstable, stochastically assembled ensembles to produce stable population-level events. Network excitability covaried with set-shifting performance, suggesting that these features may underlie dlPFC’s role in cognition.
www.cell.com
January 9, 2025 at 5:22 PM
Fascinated by how the brain networks balance flexibility and stability. Stochastic ensembles in the dlPFC show that transient, dynamic neuron networks can produce reliable population-level representations. A key to understanding cognitive flexibility and resilience!
www.cell.com/current-biol...
www.cell.com/current-biol...
Opening work email after an extended (and amazing) break can feel overwhelming. My strategy: flag and categorize each email by importance and urgency, then delete the unimportant/non-urgent ones. Today, I cleared about 80%. The Eisenhower Matrix is a game changer:
www.forbes.com/sites/hillen...
www.forbes.com/sites/hillen...
How To Get Stuff Done: The Eisenhower Matrix (a.k.a. The Urgent Vs The Important)
I have found that one of the best frameworks for helping get things done is the classic “urgent vs. important” two-by-two matrix.
www.forbes.com
January 6, 2025 at 4:01 PM
Opening work email after an extended (and amazing) break can feel overwhelming. My strategy: flag and categorize each email by importance and urgency, then delete the unimportant/non-urgent ones. Today, I cleared about 80%. The Eisenhower Matrix is a game changer:
www.forbes.com/sites/hillen...
www.forbes.com/sites/hillen...
Got to catch up with @gopu.bsky.social
December 23, 2024 at 1:09 PM
Got to catch up with @gopu.bsky.social
Reposted by Zane Lybrand
And the same for Python is here:
python-graph-gallery.com/color-palett...
python-graph-gallery.com/color-palett...
December 21, 2024 at 9:04 AM
And the same for Python is here:
python-graph-gallery.com/color-palett...
python-graph-gallery.com/color-palett...
Lots of great reviews out now on networks. Metastability is a new concept for me but digging it. Something we've observed in the lab but haven't linked to attractor dynamics or used that terminology.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Metastability demystified — the foundational past, the pragmatic present and the promising future - Nature Reviews Neuroscience
Metastability is a concept from dynamical systems. In the brain, it is thought to reflect the balance between the cooperative and independent functioning of brain areas or neuronal populations. In thi...
www.nature.com
December 14, 2024 at 1:07 PM
Lots of great reviews out now on networks. Metastability is a new concept for me but digging it. Something we've observed in the lab but haven't linked to attractor dynamics or used that terminology.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A nice review of neural oscillations across multiple timescales enable multisensory integration by aligning, segregating, and prioritizing sensory inputs.
Fig. 1 is nice. I may print and hang in my office.
www.nature.com/articles/s41...
Fig. 1 is nice. I may print and hang in my office.
www.nature.com/articles/s41...
Multi-timescale neural dynamics for multisensory integration - Nature Reviews Neuroscience
How the brain routinely processes information from different sensory modalities during everyday tasks is not well understood. In this Perspective, Engel and Senkowski propose how oscillatory neural me...
www.nature.com
December 13, 2024 at 12:52 PM
A nice review of neural oscillations across multiple timescales enable multisensory integration by aligning, segregating, and prioritizing sensory inputs.
Fig. 1 is nice. I may print and hang in my office.
www.nature.com/articles/s41...
Fig. 1 is nice. I may print and hang in my office.
www.nature.com/articles/s41...
I change my email sign-off from 'Regards' to 'Sincerely' just so you know I'm serious.
December 11, 2024 at 7:17 PM
I change my email sign-off from 'Regards' to 'Sincerely' just so you know I'm serious.
What a fascinating study on how amygdala networks shift to repetitive 'stay or switch' patterns during stress, disrupting focus on rewards! Stress rewires decision-making circuits, shedding light on how neural dynamics drive overthinking.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Understanding the neural code of stress to control anhedonia - Nature
Examination of the neural activity in the basolateral amygdala and ventral CA1 of mice during tasks or rest following exposure to social stress reveals signatures of resilience and susceptibility to s...
www.nature.com
December 5, 2024 at 5:08 AM
What a fascinating study on how amygdala networks shift to repetitive 'stay or switch' patterns during stress, disrupting focus on rewards! Stress rewires decision-making circuits, shedding light on how neural dynamics drive overthinking.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Neurons in the human brain multitask! Shared neurons fire in bursts for multiple stimuli, but their firing order shifts to create stimulus-specific sequences. A clever, dynamic way the brain encodes complex info.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Neuronal sequences in population bursts encode information in human cortex - Nature
The temporal order of neuronal firing within bursts of population spiking in the human anterior temporal lobe is dependent on the category as well as the identity of the individual stimulus, and this ...
www.nature.com
November 28, 2024 at 6:06 PM
Neurons in the human brain multitask! Shared neurons fire in bursts for multiple stimuli, but their firing order shifts to create stimulus-specific sequences. A clever, dynamic way the brain encodes complex info.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Zane Lybrand
#JNeurosci: Papale et al. mapped out connections between neurons in mice that form the cellular basis of coordinated movement planning across the two hemispheres of the frontal cortex. doi.org/10.1523/JNEU...
November 27, 2024 at 6:04 PM
#JNeurosci: Papale et al. mapped out connections between neurons in mice that form the cellular basis of coordinated movement planning across the two hemispheres of the frontal cortex. doi.org/10.1523/JNEU...
I'm going to need a starter pack of starter packs at this point.
November 26, 2024 at 12:41 PM
I'm going to need a starter pack of starter packs at this point.
I've been on Bluesky for a few months and I am really thrilled to see it taking off. Rediscovering old twitter networks over the past few days has been fun.
November 23, 2024 at 1:44 AM
I've been on Bluesky for a few months and I am really thrilled to see it taking off. Rediscovering old twitter networks over the past few days has been fun.
First time I wasn't able to make it to one of my favorite meetings but the lab still represented.
#MissionConnect
#MissionConnect
November 22, 2024 at 11:05 PM
First time I wasn't able to make it to one of my favorite meetings but the lab still represented.
#MissionConnect
#MissionConnect
Yet another report by NYT on CTE from the military. It's pervasive. We need to help them.
“Over and over and over, high-performing guys spiral down and fall apart,”
www.nytimes.com/2024/11/12/u...
“Over and over and over, high-performing guys spiral down and fall apart,”
www.nytimes.com/2024/11/12/u...
Chronic Brain Trauma Is Extensive in Navy’s Elite Speedboat Crews
The pounding that sailors’ brains take from years of high-speed wave-slamming in the Special Boat Teams can cause symptoms that wreck their careers — and their lives.
www.nytimes.com
November 13, 2024 at 12:37 PM
Yet another report by NYT on CTE from the military. It's pervasive. We need to help them.
“Over and over and over, high-performing guys spiral down and fall apart,”
www.nytimes.com/2024/11/12/u...
“Over and over and over, high-performing guys spiral down and fall apart,”
www.nytimes.com/2024/11/12/u...
Reposted by Zane Lybrand
One week from tonight. The premiere event of the Society for Neuroscience meeting. #SfN24 #SFN2024
www.reggieslive.com/show/pavlovs...
www.reggieslive.com/show/pavlovs...
October 1, 2024 at 2:25 AM
One week from tonight. The premiere event of the Society for Neuroscience meeting. #SfN24 #SFN2024
www.reggieslive.com/show/pavlovs...
www.reggieslive.com/show/pavlovs...
Reposted by Zane Lybrand
Neurophysiological signatures of default mode network dysfunction and cognitive decline in Alzheimer disease. https://www.biorxiv.org/content/10.1101/2024.09.16.613373v1
Neurophysiological signatures of default mode network dysfunction and cognitive decline in Alzheimer disease. https://www.biorxiv.org/content/10.1101/2024.09.16.613373v1
Neural hyper-excitability and network dysfunction are neurophysiological hallmarks of Alzheimer dise
www.biorxiv.org
September 18, 2024 at 9:15 AM
Neurophysiological signatures of default mode network dysfunction and cognitive decline in Alzheimer disease. https://www.biorxiv.org/content/10.1101/2024.09.16.613373v1