Yicheng Long
@yichenglong.bsky.social
Assistant Professor of Biochemistry, Weill Cornell Medicine. www.longlab.org. Studying epigenetics, nucleic acids, stem cells and heart. Cech lab alumnus
Loss of PRC2.1 or PRC2.2 in hPSCs by separation-of-function mutants led to loss of H3K27me3 in a gene-specific manner. For example, the H3K27me3 peaks at BARHL1 and ARV1 are specifically deposited by PRC2.1 and PRC2.2, respectively. This specificity is observed genome wide.
August 12, 2025 at 3:47 PM
Loss of PRC2.1 or PRC2.2 in hPSCs by separation-of-function mutants led to loss of H3K27me3 in a gene-specific manner. For example, the H3K27me3 peaks at BARHL1 and ARV1 are specifically deposited by PRC2.1 and PRC2.2, respectively. This specificity is observed genome wide.