xiuqichen.bsky.social
@xiuqichen.bsky.social
Postdoctoral researcher at TU Delft.
Trying to sequence proteins with #nanopore
😆😆
August 14, 2025 at 9:30 AM
Thanks for the kind words! It's challenging to acquire sufficient signals for cotranslational folding. I was lucky to find a strong reporter with high expression levels and nice FACS experts to help me. It's quite a journey for sure.
July 29, 2025 at 4:33 PM
🧠 I learned a lot with this project. Glad this is finally published. Check it out below:
#OpenAccess Paper link: doi.org/10.1038/s414...
Arrest Peptide Profiling resolves co-translational folding pathways and chaperone interactions in vivo - Nature Communications
Protein folding is facilitated by cellular machinery, but studying folding in the cellular context is challenging. Here, the authors developed Arrest Peptide Profiling to map co-translational folding ...
doi.org
July 24, 2025 at 8:34 PM
🤣 I found this fun picture from a few years back. To ensure high coverage of the protein truncation library, each plate can have 50K - 100K colonies 🦠. 🧵5/6
July 24, 2025 at 8:34 PM