Vignuzzi Lab
@vignuzzilab.bsky.social
Antiviral therapeutics and virology. ASTAR ID Labs in Singapore. Diversity and compassion in STEM and academia, LGBTQQIP2SAA and anyone under the rainbow. Major in virology, minor in fitness.
Who remembers sequencing their molecular cloning experiments by hand and eye?!? Running your own acrylamide gels and reading the four bases from top to bottom of gel, to only get 200 nt read from a single mini prep hoping your insert was ok!?
November 28, 2025 at 3:38 AM
Who remembers sequencing their molecular cloning experiments by hand and eye?!? Running your own acrylamide gels and reading the four bases from top to bottom of gel, to only get 200 nt read from a single mini prep hoping your insert was ok!?
Happening now! Prof Yue WANG, our pillar of Fungal biology at ASTAR ID Labs, is celebrating over 4 decades of research in his last seminar before retirement. What a great life story!
November 28, 2025 at 3:29 AM
Happening now! Prof Yue WANG, our pillar of Fungal biology at ASTAR ID Labs, is celebrating over 4 decades of research in his last seminar before retirement. What a great life story!
This was an excellent talk by a brilliant scientist, Kei Sato, from University of Tokyo, opening up a second satellite lab at Duke-NUS! Great news for Singapore virology!
November 25, 2025 at 3:47 AM
This was an excellent talk by a brilliant scientist, Kei Sato, from University of Tokyo, opening up a second satellite lab at Duke-NUS! Great news for Singapore virology!
Tomorrow at IDLabs! 10am in Matrix building, Codon room
Seminar by Kei Sato!
Seminar by Kei Sato!
November 24, 2025 at 8:24 AM
Tomorrow at IDLabs! 10am in Matrix building, Codon room
Seminar by Kei Sato!
Seminar by Kei Sato!
This week, my lab, and research institute A*IDL, and A*STAR signed an ideation agreement with Flagship Pioneering Biotech and one of their portfolio companies Apriori to develop self-amplifying RNA vaccines for pandemic Flu threats. (1/3)
November 16, 2025 at 3:19 AM
This week, my lab, and research institute A*IDL, and A*STAR signed an ideation agreement with Flagship Pioneering Biotech and one of their portfolio companies Apriori to develop self-amplifying RNA vaccines for pandemic Flu threats. (1/3)
Szarina brought in virus snowflake cutout-yourself printouts to prepare for the Singapore winter and Christmas!
November 7, 2025 at 10:15 AM
Szarina brought in virus snowflake cutout-yourself printouts to prepare for the Singapore winter and Christmas!
Today we had a computational virology workshop with Profs. Veronika Bernhauerova (Charles University Czechia) and Bartek Lisowski (Jagiellonian University Krakow, Dr. Spyros Lytras (Univ Tokyo) and Cedric Tan (UCL Crick Institute). 4 hours of chit chat and coming up with ways to collaborate.
November 6, 2025 at 9:58 AM
Today we had a computational virology workshop with Profs. Veronika Bernhauerova (Charles University Czechia) and Bartek Lisowski (Jagiellonian University Krakow, Dr. Spyros Lytras (Univ Tokyo) and Cedric Tan (UCL Crick Institute). 4 hours of chit chat and coming up with ways to collaborate.
Afternoon coffee break at Top Coffee Shop in Asia, number 6 in the world, dunno who’s list but must be an important one: Apartment Cafe. With Veronika Bernhauerova from Charles University Czechia and Bartek Lisowski of Jagiellonian University in Krakow Poland.
November 4, 2025 at 10:46 AM
Afternoon coffee break at Top Coffee Shop in Asia, number 6 in the world, dunno who’s list but must be an important one: Apartment Cafe. With Veronika Bernhauerova from Charles University Czechia and Bartek Lisowski of Jagiellonian University in Krakow Poland.
Welcome to our lab Mingcong (Albert) to our lab! Albert is from Chengdu China and will be an intern in our lab for the next seven months working with Fadi Alnaji.
October 21, 2025 at 10:46 PM
Welcome to our lab Mingcong (Albert) to our lab! Albert is from Chengdu China and will be an intern in our lab for the next seven months working with Fadi Alnaji.
Happy Diwali
Happy Deepavali
To all celebrating in Singapore and beyond!
Happy Deepavali
To all celebrating in Singapore and beyond!
October 20, 2025 at 2:36 AM
Happy Diwali
Happy Deepavali
To all celebrating in Singapore and beyond!
Happy Deepavali
To all celebrating in Singapore and beyond!
Be positive. Love thyself. Try to love others too.
October 13, 2025 at 2:24 AM
Be positive. Love thyself. Try to love others too.
Happening now. Prof. Kartik Chandran, in Singapore this week for the HCV & Flaviviruses conference, is speaking to ID Labs scientists on their coronavirus research.
October 10, 2025 at 4:15 AM
Happening now. Prof. Kartik Chandran, in Singapore this week for the HCV & Flaviviruses conference, is speaking to ID Labs scientists on their coronavirus research.
Had a reminder by my colleague Amit Singhal that two years ago to this day our faculty had a retreat in my medieval village of Noyers-sur-Serein. Missing this clunky old house! 🏰 ❤️
October 6, 2025 at 2:03 AM
Had a reminder by my colleague Amit Singhal that two years ago to this day our faculty had a retreat in my medieval village of Noyers-sur-Serein. Missing this clunky old house! 🏰 ❤️
BUT now, a million years later, my lab is revisiting all this stuff, saRNA vaccines, bacterial delivery systems, oncolytic therapies, with a modern updated touch.
READ this very cool paper by SINGER et al, one of my favourites for 2025 for sure!
READ this very cool paper by SINGER et al, one of my favourites for 2025 for sure!
September 25, 2025 at 6:16 AM
BUT now, a million years later, my lab is revisiting all this stuff, saRNA vaccines, bacterial delivery systems, oncolytic therapies, with a modern updated touch.
READ this very cool paper by SINGER et al, one of my favourites for 2025 for sure!
READ this very cool paper by SINGER et al, one of my favourites for 2025 for sure!
To restrict the spread of the oncolytic virus, they swapped one protease cleavage sites with that of Tobacco Etch virus, so only cells expressing TEVpro from the Salmonella can produce full virus. Cool safety switch!
September 25, 2025 at 6:16 AM
To restrict the spread of the oncolytic virus, they swapped one protease cleavage sites with that of Tobacco Etch virus, so only cells expressing TEVpro from the Salmonella can produce full virus. Cool safety switch!
Impressively, these oncolytic viruses launched from T7 RNA promoter in Salmonella expressing T7 polymerase, significantly reduce tumours at the injection site and at other sites, fully protecting mice against the disease.
September 25, 2025 at 6:16 AM
Impressively, these oncolytic viruses launched from T7 RNA promoter in Salmonella expressing T7 polymerase, significantly reduce tumours at the injection site and at other sites, fully protecting mice against the disease.
They use this bacteria to invade a cell and deliver an oncolytic Senecavirus RNA, which replicates, and spreads to neighbouring tumours.
September 25, 2025 at 6:16 AM
They use this bacteria to invade a cell and deliver an oncolytic Senecavirus RNA, which replicates, and spreads to neighbouring tumours.
When Salmonella infect cells, they hide themselves in a Salmonella Containing Vacuole, the sifA gene helps maintain this vacuole, both these authors and we knocked this gene out so that the Salmonella would fall into the cytoplasm for RNA delivery.
September 25, 2025 at 6:16 AM
When Salmonella infect cells, they hide themselves in a Salmonella Containing Vacuole, the sifA gene helps maintain this vacuole, both these authors and we knocked this gene out so that the Salmonella would fall into the cytoplasm for RNA delivery.
Lab 🌈 at @astar-idlabs.bsky.social annual retreat at Universal Studios Singapore! What’s your colour? Where’s your pot of gold?
September 20, 2025 at 2:37 AM
Lab 🌈 at @astar-idlabs.bsky.social annual retreat at Universal Studios Singapore! What’s your colour? Where’s your pot of gold?
My lab found me in my hiding spot when I try to avoid responsibilities.
Back to work.
Back to work.
September 12, 2025 at 4:44 AM
My lab found me in my hiding spot when I try to avoid responsibilities.
Back to work.
Back to work.
EMBO course in India in Feb 2026:
September 11, 2025 at 5:06 AM
EMBO course in India in Feb 2026:
Congratulations to Jolene Fu from the University of Malaya in Kuala Lumpur. Today she defended her PhD thesis on COVID immune escape and evolution. Excellent dissertation and oral defence.
Dr. Jolene Fu, PhD!
Dr. Jolene Fu, PhD!
September 9, 2025 at 2:41 AM
Congratulations to Jolene Fu from the University of Malaya in Kuala Lumpur. Today she defended her PhD thesis on COVID immune escape and evolution. Excellent dissertation and oral defence.
Dr. Jolene Fu, PhD!
Dr. Jolene Fu, PhD!
Immigrant to new Citizens, 1977-1980, Canada. Our Citizenship photos.
Why was my photo different? Always the odd one out!
Why was my photo different? Always the odd one out!
September 8, 2025 at 6:31 AM
Immigrant to new Citizens, 1977-1980, Canada. Our Citizenship photos.
Why was my photo different? Always the odd one out!
Why was my photo different? Always the odd one out!
Welcome to Paul Foucambert! Paul is an MD from France, seeking experience in biomedical sciences, and will be part of our Vignuzzi lab family for the next three years developing new vaccine strategies, learning about molecular virology and sharing his medical and clinical insights.
Welcome Paul!
Welcome Paul!
September 2, 2025 at 7:47 AM
Welcome to Paul Foucambert! Paul is an MD from France, seeking experience in biomedical sciences, and will be part of our Vignuzzi lab family for the next three years developing new vaccine strategies, learning about molecular virology and sharing his medical and clinical insights.
Welcome Paul!
Welcome Paul!
Welcome Dariel Tanoto to our lab!
Dariel is a Research Officer that will be working with our postdoctoral scientist Fish Poh on new RNA therapeutics.
And with that we can add 🇮🇩 to our lab flags!
Dariel is a Research Officer that will be working with our postdoctoral scientist Fish Poh on new RNA therapeutics.
And with that we can add 🇮🇩 to our lab flags!
September 1, 2025 at 5:06 AM
Welcome Dariel Tanoto to our lab!
Dariel is a Research Officer that will be working with our postdoctoral scientist Fish Poh on new RNA therapeutics.
And with that we can add 🇮🇩 to our lab flags!
Dariel is a Research Officer that will be working with our postdoctoral scientist Fish Poh on new RNA therapeutics.
And with that we can add 🇮🇩 to our lab flags!