Happy #FluorescenceFriday! This video, generated by Jose Maldonado, shows Myelin Basic Protein (MBP) in a whole-mouse brain.

MBP is a component of the myelin sheath, which insulates nerve fibers and plays an important role in nerve signal transmission. →

We are excited to highlight tissue clearing data generated by Dr. Ian Smith at @ucirvine.bsky.social. This cleared mouse brain sample, stained for amyloid (Amylo-Glo, green) and capillaries (cyan), reveals the brain’s microvascular network and amyloid pathology in intact tissue.

We appreciate the kind words from one of our kit users, Dr. Ian Smith! Dr. Smith is a Research Professor at the University of California, Irvine, and used the Translucence Universal Tissue Clearing Kit to clear a mouse brain.

Happy #FluorescenceFriday! This video, generated by Jose Maldonado, of a mouse brain stained for Tyrosine Hydroxylase (TH) reveals dopaminergic neurons using our Universal Tissue Clearing Kit!

Happy #FluorescenceFriday! iDISCO-based tissue clearing and whole-organ Light Sheet Fluorescence Microscopy (#LSFM) reveal 3D vasculature and bile duct networks in an intact mouse liver stained for Smooth Muscle Actin (cyan; vasculature) and Cytokeratin 7 (green; bile ducts).

Heidi Fresenius is a Postdoctoral Scholar at UC Irvine. Using their established antibodies and the Translucence Universal Tissue Clearing Kit, Heidi cleared ~50 µm mouse brain sections for a pilot experiment, followed by imaging on both wide field and confocal microscopes.