3️⃣ These drug effects vary between patients and may raise hepcidin, contributing to anemia risk in cancer or CKD.
Co-inhibiting BMP signaling could help balance this response.

2️⃣ Yet in liver cancer cells, diclofenac & acetaminophen amplify hepcidin via BMP-receptor stabilization — the opposite of what’s seen in primary hepatocytes.

1️⃣ Both drugs dampen IL-6–driven acute-phase proteins by boosting the feedback inhibitor SOCS3 and lowering STAT3 activation.

One aspect to highlight: Despite #signaling through the same #receptor, different #IFN subtypes induce distinct and in part contrary effects. Regulatory mechanisms seem to be deeply conserved.
Many thanks to the organizers @thebinderlab.bsky.social and Marieke Essers 3/3

It was great to see how ubiquitously interferons are involved in biology. From #stem #cell homeostasis, over cellular morphology and #antiviral defense mechanisms to anti-tumoral effects!
Big shoutout to all people presenting their in many parts unpublished work ❤️ 2/3

I am sad I miss it this year! Enjoy EuPA ❤️

Salami Tactics?

I am just sadsad