Synlett Journal
@synlettjournal.bsky.social
An international, peer-reviewed #Account and #Letter journal from Thieme reporting research results and current trends in #chemicalsynthesis.
🔗 https://www.thieme.de/de/synlett/journal-information-55964.htm
🔗 https://www.thieme.de/de/synlett/journal-information-55964.htm
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Are you an innovator in #ChemicalSynthesis? Find your audience with SYNLETT!
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Why SYNLETT:
👥 Rapid Select Crowd Review
🤝 Support for Early Career Researchers
💡 Diverse Editorial Board
...and more!
Submit today: buff.ly/2q3gEkL
Bicyclo[1.1.1]propellane reactivity unlocked🚀 Vasudevan Dhayalan reviews organolithium, Mg, Zn & B-mediated strain-release functionalization⚗️ Mild, regioselective, eco-friendly methods deliver diverse BCPs & amine scaffolds✨
#CrossCoupling
👉 buff.ly/yoME2Sa
#CrossCoupling
👉 buff.ly/yoME2Sa
December 8, 2025 at 8:01 AM
Bicyclo[1.1.1]propellane reactivity unlocked🚀 Vasudevan Dhayalan reviews organolithium, Mg, Zn & B-mediated strain-release functionalization⚗️ Mild, regioselective, eco-friendly methods deliver diverse BCPs & amine scaffolds✨
#CrossCoupling
👉 buff.ly/yoME2Sa
#CrossCoupling
👉 buff.ly/yoME2Sa
Discover the power of Small Molecules in Medicinal Chemistry🔬 at the upcoming Thieme #Cheminar
Join Profs. Arlene Gonçalves Corrêa (🇧🇷) & Kelvin Billingsley (🇺🇸) — chaired by our EiC Debabrata Maiti (🇮🇳), brought to you by @synlettjournal.bsky.social
📅December 10, 2025 ⏰5 PM (GMT+1)
👉 buff.ly/KhmBHll
Join Profs. Arlene Gonçalves Corrêa (🇧🇷) & Kelvin Billingsley (🇺🇸) — chaired by our EiC Debabrata Maiti (🇮🇳), brought to you by @synlettjournal.bsky.social
📅December 10, 2025 ⏰5 PM (GMT+1)
👉 buff.ly/KhmBHll
December 5, 2025 at 12:05 PM
Discover the power of Small Molecules in Medicinal Chemistry🔬 at the upcoming Thieme #Cheminar
Join Profs. Arlene Gonçalves Corrêa (🇧🇷) & Kelvin Billingsley (🇺🇸) — chaired by our EiC Debabrata Maiti (🇮🇳), brought to you by @synlettjournal.bsky.social
📅December 10, 2025 ⏰5 PM (GMT+1)
👉 buff.ly/KhmBHll
Join Profs. Arlene Gonçalves Corrêa (🇧🇷) & Kelvin Billingsley (🇺🇸) — chaired by our EiC Debabrata Maiti (🇮🇳), brought to you by @synlettjournal.bsky.social
📅December 10, 2025 ⏰5 PM (GMT+1)
👉 buff.ly/KhmBHll
💡 Shining new light on enantioselective protonation/ #deuteration ⚗️ In this #Synpacts article, Ban & Jiang unveil a photochemical boron-migration strategy enabling precise construction of tertiary C–H stereocenters under chiral H-bonding #catalysis 🌞
👉 buff.ly/nSlF4jg
👉 buff.ly/nSlF4jg
December 5, 2025 at 8:02 AM
💡 Shining new light on enantioselective protonation/ #deuteration ⚗️ In this #Synpacts article, Ban & Jiang unveil a photochemical boron-migration strategy enabling precise construction of tertiary C–H stereocenters under chiral H-bonding #catalysis 🌞
👉 buff.ly/nSlF4jg
👉 buff.ly/nSlF4jg
A mild, base-free route to 2- #arylquinoxalines ✨
Tung T. Nguyen & co-workers report Bu₄NI-catalyzed annulation of 1,2-phenylenediamines with (hetero)aryl sulfoxonium ylides – no electrophiles, no excess base needed 🔄
#annulation
👉 buff.ly/pdHUtbI
Tung T. Nguyen & co-workers report Bu₄NI-catalyzed annulation of 1,2-phenylenediamines with (hetero)aryl sulfoxonium ylides – no electrophiles, no excess base needed 🔄
#annulation
👉 buff.ly/pdHUtbI
December 3, 2025 at 8:01 AM
A mild, base-free route to 2- #arylquinoxalines ✨
Tung T. Nguyen & co-workers report Bu₄NI-catalyzed annulation of 1,2-phenylenediamines with (hetero)aryl sulfoxonium ylides – no electrophiles, no excess base needed 🔄
#annulation
👉 buff.ly/pdHUtbI
Tung T. Nguyen & co-workers report Bu₄NI-catalyzed annulation of 1,2-phenylenediamines with (hetero)aryl sulfoxonium ylides – no electrophiles, no excess base needed 🔄
#annulation
👉 buff.ly/pdHUtbI
New #Account just published🔥 Metal Catalysis within Tyrosine Bioconjugation 🧪 Worth checking out!
Our latest review on the use of "Metal Catalysis within Tyrosine Bioconjugation" is now published in @synlettjournal.bsky.social Many thanks for the invitation! www.thieme-connect.com/products/ejo...
December 2, 2025 at 7:58 AM
New #Account just published🔥 Metal Catalysis within Tyrosine Bioconjugation 🧪 Worth checking out!
Explore the chemistry of arene-annulated eight-membered carbocycles! Große & Wegner review #DielsAlder strategies using #cyclooctyne dienophiles, highlighting modular, flexible routes to complex polycycles⚗️ A roadmap for future functional materials & bioactive designs🌟
👉 buff.ly/EC5JhOu
👉 buff.ly/EC5JhOu
December 1, 2025 at 8:01 AM
Explore the chemistry of arene-annulated eight-membered carbocycles! Große & Wegner review #DielsAlder strategies using #cyclooctyne dienophiles, highlighting modular, flexible routes to complex polycycles⚗️ A roadmap for future functional materials & bioactive designs🌟
👉 buff.ly/EC5JhOu
👉 buff.ly/EC5JhOu
H₂-driven CuH catalysis with multifunctional NHCs⚡Guanidine- & iminopyridine NHCs expand reactivity to challenging amides & conjugated substrates🔬Unprecedented substrate scope & a step toward 3d-metal hydrogenations by Teichert et al. @teichertlab.bsky.social
#organocatalysis
👉 buff.ly/3K4tj1A
#organocatalysis
👉 buff.ly/3K4tj1A
November 29, 2025 at 5:26 AM
H₂-driven CuH catalysis with multifunctional NHCs⚡Guanidine- & iminopyridine NHCs expand reactivity to challenging amides & conjugated substrates🔬Unprecedented substrate scope & a step toward 3d-metal hydrogenations by Teichert et al. @teichertlab.bsky.social
#organocatalysis
👉 buff.ly/3K4tj1A
#organocatalysis
👉 buff.ly/3K4tj1A
Sun, Xu & Ye highlight advances in enantioselective γ- #lactam synthesis with chiral α-quaternary centers, one of the toughest challenges in #OrganicSynthesis ! Strategies include asymmetric functionalization of preformed rings & TM-catalyzed carbonylative cyclization⚠️
👉 buff.ly/3tCwIGC
👉 buff.ly/3tCwIGC
November 28, 2025 at 8:01 AM
Sun, Xu & Ye highlight advances in enantioselective γ- #lactam synthesis with chiral α-quaternary centers, one of the toughest challenges in #OrganicSynthesis ! Strategies include asymmetric functionalization of preformed rings & TM-catalyzed carbonylative cyclization⚠️
👉 buff.ly/3tCwIGC
👉 buff.ly/3tCwIGC
Ahire & Belani report a Rh(III)-catalyzed #hydroarylation of oxa- & azabenzonorbornadienes via enaminone-directed C–H activation. Mild conditions, broad substrate scope & excellent regioselectivity deliver diverse polycyclic products🔬
#rhodium #catalysis
👉 buff.ly/zytDJdF
#rhodium #catalysis
👉 buff.ly/zytDJdF
November 26, 2025 at 8:01 AM
Ahire & Belani report a Rh(III)-catalyzed #hydroarylation of oxa- & azabenzonorbornadienes via enaminone-directed C–H activation. Mild conditions, broad substrate scope & excellent regioselectivity deliver diverse polycyclic products🔬
#rhodium #catalysis
👉 buff.ly/zytDJdF
#rhodium #catalysis
👉 buff.ly/zytDJdF
Shun-Yi Wang & co-workers showcase a Ni-catalyzed strategy to build asymmetric #sulfides, #selenides & #disulfides with high efficiency and atom economy🔩Tunable via catalyst & ligand choice, it broadens #sulfur chemistry for pharma & synthesis🧪
#nickel #catalysis
👉 buff.ly/ujHOdvO
#nickel #catalysis
👉 buff.ly/ujHOdvO
November 24, 2025 at 8:01 AM
Shun-Yi Wang & co-workers showcase a Ni-catalyzed strategy to build asymmetric #sulfides, #selenides & #disulfides with high efficiency and atom economy🔩Tunable via catalyst & ligand choice, it broadens #sulfur chemistry for pharma & synthesis🧪
#nickel #catalysis
👉 buff.ly/ujHOdvO
#nickel #catalysis
👉 buff.ly/ujHOdvO
#Rhodium catalysis with a self-assembling pyridone phosphine ligand enables chemoselective #hydroformylation of protected propargylic alcohols, yielding either 4-siloxy enals or protected 4-hydroxy aldehydes depending on conditions, by Bernhard Breit & co-workers⚡
👉 buff.ly/3XSPD0C
👉 buff.ly/3XSPD0C
November 21, 2025 at 8:01 AM
#Rhodium catalysis with a self-assembling pyridone phosphine ligand enables chemoselective #hydroformylation of protected propargylic alcohols, yielding either 4-siloxy enals or protected 4-hydroxy aldehydes depending on conditions, by Bernhard Breit & co-workers⚡
👉 buff.ly/3XSPD0C
👉 buff.ly/3XSPD0C
Stannylated amino acids & peptides = versatile building blocks🧬 Easily modified via cross-couplings & metal–halogen exchange for natural product synthesis, active ingredients, or radiolabeling🔬 Overview of methods & applications by Uli Kazmaier
#OpenAcess 👉 buff.ly/pBahnhC
#OpenAcess 👉 buff.ly/pBahnhC
November 17, 2025 at 8:01 AM
Stannylated amino acids & peptides = versatile building blocks🧬 Easily modified via cross-couplings & metal–halogen exchange for natural product synthesis, active ingredients, or radiolabeling🔬 Overview of methods & applications by Uli Kazmaier
#OpenAcess 👉 buff.ly/pBahnhC
#OpenAcess 👉 buff.ly/pBahnhC
#Tetraethynylmethane: a rare, thermally unstable building block that’s fascinated chemists for decades🧪 Sebastian Beil @sebastianbeil.bsky.social report its synthesis and initial use in porous materials, though its full potential remains untapped🌟
#alkynes
👉 buff.ly/HTqx7iU
#alkynes
👉 buff.ly/HTqx7iU
November 14, 2025 at 8:01 AM
#Tetraethynylmethane: a rare, thermally unstable building block that’s fascinated chemists for decades🧪 Sebastian Beil @sebastianbeil.bsky.social report its synthesis and initial use in porous materials, though its full potential remains untapped🌟
#alkynes
👉 buff.ly/HTqx7iU
#alkynes
👉 buff.ly/HTqx7iU
Shigeki Sano & co-workers report bis(benzylthio)phosphoryl HWE-type reagents for conjugated allenyl esters, ketones, amides & phosphonodithioates. Higher reactivity vs traditional #HWE reagents & in-situ ketene preparation 🧪
#allenes
#OpenAccess 👉 buff.ly/3zpKRVt
#allenes
#OpenAccess 👉 buff.ly/3zpKRVt
November 12, 2025 at 8:01 AM
Shigeki Sano & co-workers report bis(benzylthio)phosphoryl HWE-type reagents for conjugated allenyl esters, ketones, amides & phosphonodithioates. Higher reactivity vs traditional #HWE reagents & in-situ ketene preparation 🧪
#allenes
#OpenAccess 👉 buff.ly/3zpKRVt
#allenes
#OpenAccess 👉 buff.ly/3zpKRVt
#GreenChemistry in action🌱 Satyanarayana & co-workers use #electrocatalysis as a clean reagent in electro-organic synthesis! From 3° alcohols to selenyl & sulfenyl scaffolds, their work highlights innovation in eco-friendly synthesis⚗️
👉 buff.ly/s7341tl
👉 buff.ly/s7341tl
November 10, 2025 at 8:01 AM
#GreenChemistry in action🌱 Satyanarayana & co-workers use #electrocatalysis as a clean reagent in electro-organic synthesis! From 3° alcohols to selenyl & sulfenyl scaffolds, their work highlights innovation in eco-friendly synthesis⚗️
👉 buff.ly/s7341tl
👉 buff.ly/s7341tl
💥Systematic study of nitrogen heterocycles by Samuel Oger & Gwilherm Evano! Cu-photoredox catalysis + blue light drives exo-dig radical cyclizations of sulfonamides → azetidines, pyrrolidines, piperidines & azepanes💡
#copper #photoredox #alkynes
👉 buff.ly/eFcpFwQ
#copper #photoredox #alkynes
👉 buff.ly/eFcpFwQ
November 7, 2025 at 8:01 AM
💥Systematic study of nitrogen heterocycles by Samuel Oger & Gwilherm Evano! Cu-photoredox catalysis + blue light drives exo-dig radical cyclizations of sulfonamides → azetidines, pyrrolidines, piperidines & azepanes💡
#copper #photoredox #alkynes
👉 buff.ly/eFcpFwQ
#copper #photoredox #alkynes
👉 buff.ly/eFcpFwQ
Reposted by Synlett Journal
🚀 Countdown to SCNOW Virtual Summit, 6–7 Nov! 🌱♻️
Join top experts in sustainable & circular chemistry from #academia, #industry & #policy. Connect, exchange ideas & drive impact.
💻 Register NOW: cassyni.com/s/scnow-virt...
#SCNOWVirtualSummit #SCNOWPosterSession #Sustainability
Join top experts in sustainable & circular chemistry from #academia, #industry & #policy. Connect, exchange ideas & drive impact.
💻 Register NOW: cassyni.com/s/scnow-virt...
#SCNOWVirtualSummit #SCNOWPosterSession #Sustainability
October 28, 2025 at 11:21 AM
🚀 Countdown to SCNOW Virtual Summit, 6–7 Nov! 🌱♻️
Join top experts in sustainable & circular chemistry from #academia, #industry & #policy. Connect, exchange ideas & drive impact.
💻 Register NOW: cassyni.com/s/scnow-virt...
#SCNOWVirtualSummit #SCNOWPosterSession #Sustainability
Join top experts in sustainable & circular chemistry from #academia, #industry & #policy. Connect, exchange ideas & drive impact.
💻 Register NOW: cassyni.com/s/scnow-virt...
#SCNOWVirtualSummit #SCNOWPosterSession #Sustainability
Advancing #phosphole chemistry! ✨ Our Account by Shibo Xu & Koji Hirano highlights regioselective C–H functionalization of benzophospholes via Pd-catalysis, photoredox, & photo-promoted #annulation 💡
#palladium
👉 buff.ly/lHhUqGs
#palladium
👉 buff.ly/lHhUqGs
November 5, 2025 at 8:01 AM
Advancing #phosphole chemistry! ✨ Our Account by Shibo Xu & Koji Hirano highlights regioselective C–H functionalization of benzophospholes via Pd-catalysis, photoredox, & photo-promoted #annulation 💡
#palladium
👉 buff.ly/lHhUqGs
#palladium
👉 buff.ly/lHhUqGs
Tackling the challenge of γ-lactams with chiral α-quaternary carbons! This #Synpacts article by Mengchun Ye & co-workers highlights asymmetric ring decoration & TM-catalyzed carbonylative cyclization, plus future directions🚀
#lactams #catalysis
👉 buff.ly/PGx50Dq
#lactams #catalysis
👉 buff.ly/PGx50Dq
November 3, 2025 at 8:01 AM
Tackling the challenge of γ-lactams with chiral α-quaternary carbons! This #Synpacts article by Mengchun Ye & co-workers highlights asymmetric ring decoration & TM-catalyzed carbonylative cyclization, plus future directions🚀
#lactams #catalysis
👉 buff.ly/PGx50Dq
#lactams #catalysis
👉 buff.ly/PGx50Dq
Reposted by Synlett Journal
📢📜In this #Synpacts (@synlettjournal.bsky.social), we showcase how electrosynthesis enabled the design of innovative diastereo- and enantioselective alkene 1,2-difunctionalization reactions. These contributions have inspired a complementary “Sew & Cut” strategy
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www.thieme-connect.com/products/ejo...
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October 31, 2025 at 10:22 AM
📢📜In this #Synpacts (@synlettjournal.bsky.social), we showcase how electrosynthesis enabled the design of innovative diastereo- and enantioselective alkene 1,2-difunctionalization reactions. These contributions have inspired a complementary “Sew & Cut” strategy
www.thieme-connect.com/products/ejo...
www.thieme-connect.com/products/ejo...
First nickel-catalyzed reductive #CrossCoupling of aldehydes & alkenyl halides🚀 Takuya Kurahashi report a stereoconvergent route to allyl alcohols🌟 Enabled by silyl activation & polarity inversion, this strategy tackles a long-standing challenge in synthesis🧪
#nickel
👉 buff.ly/86v9fyB
#nickel
👉 buff.ly/86v9fyB
October 31, 2025 at 8:01 AM
First nickel-catalyzed reductive #CrossCoupling of aldehydes & alkenyl halides🚀 Takuya Kurahashi report a stereoconvergent route to allyl alcohols🌟 Enabled by silyl activation & polarity inversion, this strategy tackles a long-standing challenge in synthesis🧪
#nickel
👉 buff.ly/86v9fyB
#nickel
👉 buff.ly/86v9fyB
Protecting-group-free #glycosylations are reshaping #glycoscience 🧪 From Ca²⁺-mediated regioselective reactions to #Mitsunobu + photoredox strategies, new methods enable direct, selective glycoside synthesis with high efficiency in our Account by Dey & Jayaraman⚡
👉 buff.ly/lGbhN9i
👉 buff.ly/lGbhN9i
October 29, 2025 at 8:02 AM
Protecting-group-free #glycosylations are reshaping #glycoscience 🧪 From Ca²⁺-mediated regioselective reactions to #Mitsunobu + photoredox strategies, new methods enable direct, selective glycoside synthesis with high efficiency in our Account by Dey & Jayaraman⚡
👉 buff.ly/lGbhN9i
👉 buff.ly/lGbhN9i
#Alkene radical anions in the spotlight🧪 In this #Synpacts article, Polyzos & co-workers highlight advances in C(sp³)–C(sp³) bond formation via #photoredox & #electrosynthesis 🔋 Featuring electroreductive alkene–aldehyde coupling enabled by rapid alternating polarity⚡
👉 buff.ly/uarxdeA
👉 buff.ly/uarxdeA
October 27, 2025 at 8:02 AM
#Alkene radical anions in the spotlight🧪 In this #Synpacts article, Polyzos & co-workers highlight advances in C(sp³)–C(sp³) bond formation via #photoredox & #electrosynthesis 🔋 Featuring electroreductive alkene–aldehyde coupling enabled by rapid alternating polarity⚡
👉 buff.ly/uarxdeA
👉 buff.ly/uarxdeA
First MnO₂/I₂-catalyzed one-pot synthesis of benzo[d]imidazo[2,1-b]thiazoles!🚀 G. Anilkumar & co-workers achieve this via an #OrtolevaKing type reaction⚡This work showcases broad substrate scope, delivers good yields, and paves the way to fused #heterocycles 🧪
#manganese #iodine
👉 buff.ly/fh0Goya
#manganese #iodine
👉 buff.ly/fh0Goya
October 24, 2025 at 7:02 AM
First MnO₂/I₂-catalyzed one-pot synthesis of benzo[d]imidazo[2,1-b]thiazoles!🚀 G. Anilkumar & co-workers achieve this via an #OrtolevaKing type reaction⚡This work showcases broad substrate scope, delivers good yields, and paves the way to fused #heterocycles 🧪
#manganese #iodine
👉 buff.ly/fh0Goya
#manganese #iodine
👉 buff.ly/fh0Goya
Creative ligand design meets #GoldCatalysis 🌟 Antonio Echavarren & co-workers @iciq.org unveil novel chiral scaffolds 🧬to tackle #alkyne activation with a focus on 1,6-enyne cycloisomerization & #cycloaddition✨
#OpenAccess 👉 buff.ly/GMT9qrL
#OpenAccess 👉 buff.ly/GMT9qrL
October 22, 2025 at 7:01 AM
Creative ligand design meets #GoldCatalysis 🌟 Antonio Echavarren & co-workers @iciq.org unveil novel chiral scaffolds 🧬to tackle #alkyne activation with a focus on 1,6-enyne cycloisomerization & #cycloaddition✨
#OpenAccess 👉 buff.ly/GMT9qrL
#OpenAccess 👉 buff.ly/GMT9qrL