Sinead Stoneman
@sstoneman.bsky.social
🇮🇪 Nephrologist. GN fellow in 🇨🇦.
Reposted by Sinead Stoneman
Yes. This is a game changer. Beyond being able to replace AVS, it allows one to “see” the underlying pathological contributors to a large proportion of “idiopathic” hypertension. This is another piece of evidence that should make clinicians rethink the pathogenesis and treatment of hypertension
November 28, 2025 at 6:05 PM
Yes. This is a game changer. Beyond being able to replace AVS, it allows one to “see” the underlying pathological contributors to a large proportion of “idiopathic” hypertension. This is another piece of evidence that should make clinicians rethink the pathogenesis and treatment of hypertension
Reposted by Sinead Stoneman
Ok, we have a winner. Thanks. bsky.app/profile/matt...
Tell them while pretending to be a chatbot
November 27, 2025 at 7:42 AM
Ok, we have a winner. Thanks. bsky.app/profile/matt...
Reposted by Sinead Stoneman
2025 @thelancet.com #CKD seminar out! Read it for latest evidence on how to manage what is projected to become a top
5 leading cause of death globally by 2050 (read it so in 25years’ time that does not happen…):
www.sciencedirect.com/science/arti...
5 leading cause of death globally by 2050 (read it so in 25years’ time that does not happen…):
www.sciencedirect.com/science/arti...
November 26, 2025 at 4:02 AM
2025 @thelancet.com #CKD seminar out! Read it for latest evidence on how to manage what is projected to become a top
5 leading cause of death globally by 2050 (read it so in 25years’ time that does not happen…):
www.sciencedirect.com/science/arti...
5 leading cause of death globally by 2050 (read it so in 25years’ time that does not happen…):
www.sciencedirect.com/science/arti...
Reposted by Sinead Stoneman
I think Aliza Thompson is an unsung hero in this story for spearheading the albuminuria acceptance at FDA
journals.lww.com/cjasn/pages/...
#NephJC
journals.lww.com/cjasn/pages/...
#NephJC
journals.lww.com
November 19, 2025 at 3:00 AM
I think Aliza Thompson is an unsung hero in this story for spearheading the albuminuria acceptance at FDA
journals.lww.com/cjasn/pages/...
#NephJC
journals.lww.com/cjasn/pages/...
#NephJC
Reposted by Sinead Stoneman
Clinical Variability of ADPKD in Monozygotic Twins www.kireports.org/article/S246...
November 15, 2025 at 2:50 PM
Clinical Variability of ADPKD in Monozygotic Twins www.kireports.org/article/S246...
Reposted by Sinead Stoneman
And paper 3 from @cervantes-lily1.bsky.social
On adaptation of the Navigate Kidney intervention in @kireports.bsky.social
www.kireports.org/article/S246...
#KidneyWk
On adaptation of the Navigate Kidney intervention in @kireports.bsky.social
www.kireports.org/article/S246...
#KidneyWk
November 8, 2025 at 1:24 AM
And paper 3 from @cervantes-lily1.bsky.social
On adaptation of the Navigate Kidney intervention in @kireports.bsky.social
www.kireports.org/article/S246...
#KidneyWk
On adaptation of the Navigate Kidney intervention in @kireports.bsky.social
www.kireports.org/article/S246...
#KidneyWk
Reposted by Sinead Stoneman
And the GBD analysis on CKD
From @paddymark.bsky.social and colleagues
www.thelancet.com/journals/lan... in @thelancet.com
#KidneyWk
From @paddymark.bsky.social and colleagues
www.thelancet.com/journals/lan... in @thelancet.com
#KidneyWk
Global, regional, and national burden of chronic kidney disease in adults, 1990–2023, and its attributable risk factors: a systematic analysis for the Global Burden of Disease Study 2023
CKD is a major global health issue, with rising prevalence and increasing importance
as a cause of death and as a risk factor for cardiovascular death. A better understating
of aetiology, appropriate ...
www.thelancet.com
November 8, 2025 at 12:14 AM
And the GBD analysis on CKD
From @paddymark.bsky.social and colleagues
www.thelancet.com/journals/lan... in @thelancet.com
#KidneyWk
From @paddymark.bsky.social and colleagues
www.thelancet.com/journals/lan... in @thelancet.com
#KidneyWk
Reposted by Sinead Stoneman
Trials coming out already!
jamanetwork.com/journals/jam...
Rituximab better than placebo in FRNS/SDNS
Duh.
#KidneyWk #NephSky
jamanetwork.com/journals/jam...
Rituximab better than placebo in FRNS/SDNS
Duh.
#KidneyWk #NephSky
November 5, 2025 at 8:33 PM
Trials coming out already!
jamanetwork.com/journals/jam...
Rituximab better than placebo in FRNS/SDNS
Duh.
#KidneyWk #NephSky
jamanetwork.com/journals/jam...
Rituximab better than placebo in FRNS/SDNS
Duh.
#KidneyWk #NephSky
Reposted by Sinead Stoneman
Another simultaneous publication from the afternoon session
Albuminuria as an acceptable surrogate outcome (per our discussion earlier today)
www.nature.com/articles/s41... in @naturemedicine.bsky.social @nature.com sadly paywalled
#KidneyWk
Albuminuria as an acceptable surrogate outcome (per our discussion earlier today)
www.nature.com/articles/s41... in @naturemedicine.bsky.social @nature.com sadly paywalled
#KidneyWk
A meta-analysis of albuminuria as a surrogate endpoint for kidney failure - Nature Medicine
In a meta-analysis of 48 randomized trials of chronic kidney disease progression, reduction in the 6-month urinary albumin:creatinine ratio was associated with lower hazard ratios of established kidne...
www.nature.com
November 6, 2025 at 10:49 PM
Another simultaneous publication from the afternoon session
Albuminuria as an acceptable surrogate outcome (per our discussion earlier today)
www.nature.com/articles/s41... in @naturemedicine.bsky.social @nature.com sadly paywalled
#KidneyWk
Albuminuria as an acceptable surrogate outcome (per our discussion earlier today)
www.nature.com/articles/s41... in @naturemedicine.bsky.social @nature.com sadly paywalled
#KidneyWk
Reposted by Sinead Stoneman
ORIGIN phase 3 trial: In an interim analysis of a clinical trial, atacicept, a fusion protein that binds and inhibits two cytokines thought to be central to the pathophysiology of IgA nephropathy, significantly reduced proteinuria. nej.md/3JEq8QL
@asnkidney.bsky.social | #KidneyWk
@asnkidney.bsky.social | #KidneyWk
November 6, 2025 at 2:55 PM
ORIGIN phase 3 trial: In an interim analysis of a clinical trial, atacicept, a fusion protein that binds and inhibits two cytokines thought to be central to the pathophysiology of IgA nephropathy, significantly reduced proteinuria. nej.md/3JEq8QL
@asnkidney.bsky.social | #KidneyWk
@asnkidney.bsky.social | #KidneyWk
Reposted by Sinead Stoneman
The KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease recommends using equations that include both creatinine and cystatin C for more accurate GFR estimation and risk assessment in CKD.
ja.ma/43QS5vy
ja.ma/43QS5vy
November 5, 2025 at 4:30 PM
The KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease recommends using equations that include both creatinine and cystatin C for more accurate GFR estimation and risk assessment in CKD.
ja.ma/43QS5vy
ja.ma/43QS5vy
Reposted by Sinead Stoneman
I like to lump patients with type IV collagen variants into 4 main categories that can help predict risk of progression and recommended treatment. #KidneyWk
November 6, 2025 at 6:39 PM
I like to lump patients with type IV collagen variants into 4 main categories that can help predict risk of progression and recommended treatment. #KidneyWk
Reposted by Sinead Stoneman
Highlights from my talk yesterday on Alport syndrome spectrum of disorders. (since no one posted it, I'll have to do it myself)
Variants in type IV collagen cause a wide spectrum of disease. #KidneyWk 🧵
Variants in type IV collagen cause a wide spectrum of disease. #KidneyWk 🧵
November 6, 2025 at 6:39 PM
Highlights from my talk yesterday on Alport syndrome spectrum of disorders. (since no one posted it, I'll have to do it myself)
Variants in type IV collagen cause a wide spectrum of disease. #KidneyWk 🧵
Variants in type IV collagen cause a wide spectrum of disease. #KidneyWk 🧵
Reposted by Sinead Stoneman
Forgot to post the two at plenary on Thursday
FINEONE: finerenone in T1DM
ORIGIN: Atacicept (pronounced attack-e-sept) in IgAN (pronounced eye-gee-A-N)
Possible NEJM or Lancet simulpubs?
#KidneyWk
FINEONE: finerenone in T1DM
ORIGIN: Atacicept (pronounced attack-e-sept) in IgAN (pronounced eye-gee-A-N)
Possible NEJM or Lancet simulpubs?
#KidneyWk
November 5, 2025 at 7:17 PM
Reposted by Sinead Stoneman
Fantastic Day 1 ✅ #KidneyWk @asnkidney.bsky.social
November 5, 2025 at 11:37 PM
Fantastic Day 1 ✅ #KidneyWk @asnkidney.bsky.social
Reposted by Sinead Stoneman
Idea for a Christmas BMJ paper: submit loads of Christmas BMJ papers, then do a survival analysis of time to rejection. Then submit the survival analysis as a Christmas BMJ paper the following year
October 29, 2025 at 10:05 AM
Idea for a Christmas BMJ paper: submit loads of Christmas BMJ papers, then do a survival analysis of time to rejection. Then submit the survival analysis as a Christmas BMJ paper the following year
Reposted by Sinead Stoneman
Crescents at various stages of maturation (cellular, fibrocellular, fibrous):
November 23, 2024 at 12:36 AM
Crescents at various stages of maturation (cellular, fibrocellular, fibrous):
I’m Sinead and I “have a faulty amygdala”. As per a neurologist I worked for.
I’m Nayan and I have the “you can’t leave before the attending even if you’re done with your work” problem
I’m Josh, and I have the “too many words come out of my mouth” problem.
(This was actually great feedback in the context it was given)
(This was actually great feedback in the context it was given)
November 23, 2024 at 1:38 AM
I’m Sinead and I “have a faulty amygdala”. As per a neurologist I worked for.
Reposted by Sinead Stoneman
November 22, 2024 at 9:47 PM
Reposted by Sinead Stoneman
“Patients who are diagnosed with ACE inhibitor-induced angioedema should be tested for hereditary angioedema types 1/2“
So far, not something that I have been doing …
#whatilearnedtoday #nephsky #skyneph
onlinelibrary.wiley.com/doi/10.1111/...
So far, not something that I have been doing …
#whatilearnedtoday #nephsky #skyneph
onlinelibrary.wiley.com/doi/10.1111/...
The international WAO/EAACI guideline for the management of hereditary angioedema—The 2021 revision and update
Click on the article title to read more.
onlinelibrary.wiley.com
November 21, 2024 at 12:37 PM
“Patients who are diagnosed with ACE inhibitor-induced angioedema should be tested for hereditary angioedema types 1/2“
So far, not something that I have been doing …
#whatilearnedtoday #nephsky #skyneph
onlinelibrary.wiley.com/doi/10.1111/...
So far, not something that I have been doing …
#whatilearnedtoday #nephsky #skyneph
onlinelibrary.wiley.com/doi/10.1111/...
Reposted by Sinead Stoneman
❄️🌬" Snow White Tales in Nephrology" ❄️
💥Our latest article collects evidences from the published literature between skin whitening creams and glomerular diseases. 🌟 🩺
https://buff.ly/3CBzGIy
💥Our latest article collects evidences from the published literature between skin whitening creams and glomerular diseases. 🌟 🩺
https://buff.ly/3CBzGIy
November 21, 2024 at 8:49 AM
❄️🌬" Snow White Tales in Nephrology" ❄️
💥Our latest article collects evidences from the published literature between skin whitening creams and glomerular diseases. 🌟 🩺
https://buff.ly/3CBzGIy
💥Our latest article collects evidences from the published literature between skin whitening creams and glomerular diseases. 🌟 🩺
https://buff.ly/3CBzGIy
Reposted by Sinead Stoneman
📢
Our systematic review published in BMC Nephrology examines the potential of continuous glucose monitoring (CGM) in improving glycemic control for patients with diabetes and the challenges of managing blood glucose levels in this unique population and highlights promising results from CGM use.
Our systematic review published in BMC Nephrology examines the potential of continuous glucose monitoring (CGM) in improving glycemic control for patients with diabetes and the challenges of managing blood glucose levels in this unique population and highlights promising results from CGM use.
November 20, 2024 at 8:13 PM
📢
Our systematic review published in BMC Nephrology examines the potential of continuous glucose monitoring (CGM) in improving glycemic control for patients with diabetes and the challenges of managing blood glucose levels in this unique population and highlights promising results from CGM use.
Our systematic review published in BMC Nephrology examines the potential of continuous glucose monitoring (CGM) in improving glycemic control for patients with diabetes and the challenges of managing blood glucose levels in this unique population and highlights promising results from CGM use.
Reposted by Sinead Stoneman
Still very cool to sit in grand rounds and see a #VisualAbstract after #VisualAbstract make it into the slide deck.
Hard to underestimate how much good science AND good design helps dissemination.
#medsky
Hard to underestimate how much good science AND good design helps dissemination.
#medsky
November 21, 2024 at 12:33 PM
Still very cool to sit in grand rounds and see a #VisualAbstract after #VisualAbstract make it into the slide deck.
Hard to underestimate how much good science AND good design helps dissemination.
#medsky
Hard to underestimate how much good science AND good design helps dissemination.
#medsky
Reposted by Sinead Stoneman
Just landed here! Looks very good. Happy to meet so many known faces here.
November 20, 2024 at 7:39 PM
Just landed here! Looks very good. Happy to meet so many known faces here.