Sri Devan Appasamy
@sri-appasamy.bsky.social
Bioinformatician at @pdbeurope.bsky.social | Working with macromolecular complexes and RNA. Exploring AI, tech, and the intersection of biology and computing.
ORCID profile: https://orcid.org/0000-0001-6609-3535
ORCID profile: https://orcid.org/0000-0001-6609-3535
💊 What if we could design drugs for RNA, not just proteins?
lncRNAs like MALAT1, NEAT1, HOTAIR, and GAS5 have structured domains containing loops and bulges that drive function — and can be targeted to treat disease.
Link to paper: tinyurl.com/2vfafxnn
#RNA #lncRNA #DrugDiscovery
lncRNAs like MALAT1, NEAT1, HOTAIR, and GAS5 have structured domains containing loops and bulges that drive function — and can be targeted to treat disease.
Link to paper: tinyurl.com/2vfafxnn
#RNA #lncRNA #DrugDiscovery
August 12, 2025 at 3:58 AM
💊 What if we could design drugs for RNA, not just proteins?
lncRNAs like MALAT1, NEAT1, HOTAIR, and GAS5 have structured domains containing loops and bulges that drive function — and can be targeted to treat disease.
Link to paper: tinyurl.com/2vfafxnn
#RNA #lncRNA #DrugDiscovery
lncRNAs like MALAT1, NEAT1, HOTAIR, and GAS5 have structured domains containing loops and bulges that drive function — and can be targeted to treat disease.
Link to paper: tinyurl.com/2vfafxnn
#RNA #lncRNA #DrugDiscovery
Cryo-EM can resolve high-resolution structures of small (~200 nt) protein-free ncRNAs using a scaffold-based approach. This breakthrough opens new possibilities for studying RNA structures and advancing RNA-targeted drug discovery
Link: lnkd.in/deQ_s4Tg
Link: lnkd.in/deQ_s4Tg
January 21, 2025 at 6:26 PM
Cryo-EM can resolve high-resolution structures of small (~200 nt) protein-free ncRNAs using a scaffold-based approach. This breakthrough opens new possibilities for studying RNA structures and advancing RNA-targeted drug discovery
Link: lnkd.in/deQ_s4Tg
Link: lnkd.in/deQ_s4Tg