Reposted by haysamrady
New study alert! In kidney transplant patients with chronic active AMR, monthly tocilizumab infusions slowed the decline in kidney function and even cleared donor-specific antibodies in 22% of patients after one year #TXPforALL #OpenAccess tinyurl.com/ycy2cw89
November 28, 2025 at 1:00 PM
New study alert! In kidney transplant patients with chronic active AMR, monthly tocilizumab infusions slowed the decline in kidney function and even cleared donor-specific antibodies in 22% of patients after one year #TXPforALL #OpenAccess tinyurl.com/ycy2cw89
Reposted by haysamrady
Here is today’s #eyeSCANdy! Acellular scanning EM showing RBCs (including an acanthocyte) entrapped in a crescent.
Photo courtesy of Dr. Stephen Bonsib. #renal #pathology #kidneypath
Photo courtesy of Dr. Stephen Bonsib. #renal #pathology #kidneypath
November 28, 2025 at 7:31 PM
Here is today’s #eyeSCANdy! Acellular scanning EM showing RBCs (including an acanthocyte) entrapped in a crescent.
Photo courtesy of Dr. Stephen Bonsib. #renal #pathology #kidneypath
Photo courtesy of Dr. Stephen Bonsib. #renal #pathology #kidneypath
Reposted by haysamrady
An aldosterone synthase (CYP11B2 enzyme)–specific 18F-labeled radioligand to help lateralize in PA
www.nejm.org/doi/full/10....
very cool science and technology
Any comments from the Aldo experts? @anandvaidya17.bsky.social
#NephSky #EndoSky
www.nejm.org/doi/full/10....
very cool science and technology
Any comments from the Aldo experts? @anandvaidya17.bsky.social
#NephSky #EndoSky
November 28, 2025 at 3:56 PM
An aldosterone synthase (CYP11B2 enzyme)–specific 18F-labeled radioligand to help lateralize in PA
www.nejm.org/doi/full/10....
very cool science and technology
Any comments from the Aldo experts? @anandvaidya17.bsky.social
#NephSky #EndoSky
www.nejm.org/doi/full/10....
very cool science and technology
Any comments from the Aldo experts? @anandvaidya17.bsky.social
#NephSky #EndoSky
Reposted by haysamrady
Join the Filtrate and Jon Barratt as he takes an IgAN inspired victory lap
FF 86 Atacicept for IgAN
www.nephjc.com/freelyfilter...
FF 86 Atacicept for IgAN
www.nephjc.com/freelyfilter...
FF 86 Atacicept for IgAN with Jon Barratt — NephJC
FF 86 Atacicept for IgAN with Jon Barratt
www.nephjc.com
November 28, 2025 at 3:01 PM
Join the Filtrate and Jon Barratt as he takes an IgAN inspired victory lap
FF 86 Atacicept for IgAN
www.nephjc.com/freelyfilter...
FF 86 Atacicept for IgAN
www.nephjc.com/freelyfilter...
A Consensus Statement on the management of Vertebral Fractures in CKD stages G4-G5D
#nephsky #nephrology
academic.oup.com/ndt/advance-...
#nephsky #nephrology
academic.oup.com/ndt/advance-...
A Consensus Statement on the management of Vertebral Fractures in CKD stages G4-G5D
Abstract. Skeletal fragility has long been overlooked by the nephrology community, despite patients with chronic kidney disease (CKD) facing double the ris
academic.oup.com
November 29, 2025 at 4:25 AM
A Consensus Statement on the management of Vertebral Fractures in CKD stages G4-G5D
#nephsky #nephrology
academic.oup.com/ndt/advance-...
#nephsky #nephrology
academic.oup.com/ndt/advance-...
Targeting of HIF2-driven cachexia in kidney cancer
#nephsky #nephrology
www.nature.com/articles/s41...
#nephsky #nephrology
www.nature.com/articles/s41...
Targeting of HIF2-driven cachexia in kidney cancer - Nature Medicine
In vivo experiments and clinical cohort analyses show that hypoxia-inducible factor 2 (HIF2)-induced parathyroid hormone-related protein (PTHrP) expression contributes to cachexia in the context of re...
www.nature.com
November 28, 2025 at 12:41 PM
Targeting of HIF2-driven cachexia in kidney cancer
#nephsky #nephrology
www.nature.com/articles/s41...
#nephsky #nephrology
www.nature.com/articles/s41...
Reposted by haysamrady
Betaine has previously been linked to improved health, but it hasn't been connected to exercise before.
In this study, a team led by researchers from the Xuanwu Hospital Capital Medical University in China found that long-term exercise boosts levels of betaine in the body, via the kidneys.
In this study, a team led by researchers from the Xuanwu Hospital Capital Medical University in China found that long-term exercise boosts levels of betaine in the body, via the kidneys.
Scientists Pinpoint One Key Molecule Behind Exercise's Anti-Aging Power — ScienceAlert
apple.news
November 27, 2025 at 7:59 PM
Betaine has previously been linked to improved health, but it hasn't been connected to exercise before.
In this study, a team led by researchers from the Xuanwu Hospital Capital Medical University in China found that long-term exercise boosts levels of betaine in the body, via the kidneys.
In this study, a team led by researchers from the Xuanwu Hospital Capital Medical University in China found that long-term exercise boosts levels of betaine in the body, via the kidneys.
Reposted by haysamrady
November 27, 2025 at 11:32 AM
Reposted by haysamrady
OMG! A nationally televised commercial for urine albumin to creatinine ratio!
November 27, 2025 at 4:37 PM
OMG! A nationally televised commercial for urine albumin to creatinine ratio!
Cryoglobulinemia: An update on classification, pathophysiology, clinical presentation, and management
#nephsky #nephrology
onlinelibrary.wiley.com/doi/10.1111/...
#nephsky #nephrology
onlinelibrary.wiley.com/doi/10.1111/...
<em>Journal of Internal Medicine</em> | Wiley Online Library
Cryoglobulinemia (CG) is defined by the presence of serum immunoglobulins that precipitate below 37°C and redissolve upon rewarming. It is classified into three types based on immunoglobulin composit...
onlinelibrary.wiley.com
November 27, 2025 at 9:04 AM
Cryoglobulinemia: An update on classification, pathophysiology, clinical presentation, and management
#nephsky #nephrology
onlinelibrary.wiley.com/doi/10.1111/...
#nephsky #nephrology
onlinelibrary.wiley.com/doi/10.1111/...
Reposted by haysamrady
Low rates of testing could mean that up to two thirds of people at risk for chronic kidney disease may have unrecognised albuminuria.
What should doctors know about interpretation, treatment, & follow-up?
Includes a visual summary - click the link to view in full #MedEd
www.bmj.com/content/391/...
What should doctors know about interpretation, treatment, & follow-up?
Includes a visual summary - click the link to view in full #MedEd
www.bmj.com/content/391/...
November 26, 2025 at 1:28 PM
Low rates of testing could mean that up to two thirds of people at risk for chronic kidney disease may have unrecognised albuminuria.
What should doctors know about interpretation, treatment, & follow-up?
Includes a visual summary - click the link to view in full #MedEd
www.bmj.com/content/391/...
What should doctors know about interpretation, treatment, & follow-up?
Includes a visual summary - click the link to view in full #MedEd
www.bmj.com/content/391/...
Reposted by haysamrady
Case report: Belimumab combined with mycophenolate mofetil in a child with frequently relapsing, steroid-dependent nephrotic syndrome
#nephsky
#nephsky
Belimumab combined with mycophenolate mofetil in a child with frequently relapsing, steroid-dependent nephrotic syndrome - Pediatric Nephrology
Frequently relapsing, steroid-dependent nephrotic syndrome (FRNS/SDNS) remains a therapeutic challenge. Rituximab, a B-cell-depleting agent, is effective and widely used for FRNS/SDNS, but its use…
buff.ly
November 26, 2025 at 2:01 PM
Case report: Belimumab combined with mycophenolate mofetil in a child with frequently relapsing, steroid-dependent nephrotic syndrome
#nephsky
#nephsky
Reposted by haysamrady
November 26, 2025 at 2:08 PM
Reposted by haysamrady
So many eosinophils in this case of tubulointerstitial nephritis secondary to recent antibiotic administration. Few tiny granulomas as well. Eos seen in EM as well. #renalpath #pathsky #nephsky
November 26, 2025 at 11:51 PM
So many eosinophils in this case of tubulointerstitial nephritis secondary to recent antibiotic administration. Few tiny granulomas as well. Eos seen in EM as well. #renalpath #pathsky #nephsky
Reposted by haysamrady
Cholemic Nephropathy aka Cholemic Nephrosis aka Bile Acid/ Bile Cast Nephropathy ca. 2024
#Nephpearls #NephSky
👉🏼 pubmed.ncbi.nlm.nih.gov/38649215/
#Nephpearls #NephSky
👉🏼 pubmed.ncbi.nlm.nih.gov/38649215/
November 26, 2025 at 10:43 PM
Cholemic Nephropathy aka Cholemic Nephrosis aka Bile Acid/ Bile Cast Nephropathy ca. 2024
#Nephpearls #NephSky
👉🏼 pubmed.ncbi.nlm.nih.gov/38649215/
#Nephpearls #NephSky
👉🏼 pubmed.ncbi.nlm.nih.gov/38649215/
Reposted by haysamrady
Apixaban and warfarin being similar is also a red flag
And with LAOO is such a huge selection bias
The SAFE-D trial (pilot; pubmed.ncbi.nlm.nih.gov/39495569/) is now funded to examine apixaban properly
#NephSky
And with LAOO is such a huge selection bias
The SAFE-D trial (pilot; pubmed.ncbi.nlm.nih.gov/39495569/) is now funded to examine apixaban properly
#NephSky
Anticoagulation for Patients with Atrial Fibrillation Receiving Dialysis: A Pilot Randomized Controlled Trial - PubMed
This article contains a podcast at https://dts.podtrac.com/redirect.mp3/www.asn-online.org/media/podcast/JASN/2025_04_09_ASN0000000000000495.mp3 …
pubmed.ncbi.nlm.nih.gov
November 26, 2025 at 11:10 PM
Apixaban and warfarin being similar is also a red flag
And with LAOO is such a huge selection bias
The SAFE-D trial (pilot; pubmed.ncbi.nlm.nih.gov/39495569/) is now funded to examine apixaban properly
#NephSky
And with LAOO is such a huge selection bias
The SAFE-D trial (pilot; pubmed.ncbi.nlm.nih.gov/39495569/) is now funded to examine apixaban properly
#NephSky
Reposted by haysamrady
Sibeprenlimab: First @fda.gov approved therapy targeting B cells which produce the abnormal antibodies responsible for #IgAN, addressing the fundamental cause
#Nephpearls #NephSky
#VisualAbstract by @nephroseeker.medsky.social
👉🏼 www.fda.gov/drugs/news-e...
👉🏼 pubmed.ncbi.nlm.nih.gov/41211929/
#Nephpearls #NephSky
#VisualAbstract by @nephroseeker.medsky.social
👉🏼 www.fda.gov/drugs/news-e...
👉🏼 pubmed.ncbi.nlm.nih.gov/41211929/
November 27, 2025 at 2:40 AM
Sibeprenlimab: First @fda.gov approved therapy targeting B cells which produce the abnormal antibodies responsible for #IgAN, addressing the fundamental cause
#Nephpearls #NephSky
#VisualAbstract by @nephroseeker.medsky.social
👉🏼 www.fda.gov/drugs/news-e...
👉🏼 pubmed.ncbi.nlm.nih.gov/41211929/
#Nephpearls #NephSky
#VisualAbstract by @nephroseeker.medsky.social
👉🏼 www.fda.gov/drugs/news-e...
👉🏼 pubmed.ncbi.nlm.nih.gov/41211929/
Antimeningococcal protection in patients receiving terminal complement inhibitors
#nephsky #nephrology
www.kireports.org/article/S246...
#nephsky #nephrology
www.kireports.org/article/S246...
Antimeningococcal protection in patients receiving terminal complement inhibitors
C5 inhibitor (C5i) therapy markedly increases susceptibility to invasive meningococcal
disease (IMD) by blocking the terminal complement pathway essential for defense against
Neisseria meningitidis. V...
www.kireports.org
November 26, 2025 at 6:46 AM
Antimeningococcal protection in patients receiving terminal complement inhibitors
#nephsky #nephrology
www.kireports.org/article/S246...
#nephsky #nephrology
www.kireports.org/article/S246...
Reposted by haysamrady
Interesting read on the protective p.N264k (M1) #APOL1 variant and #kidneydisease and #FSGS.
More to come soon on M1…. Stay tuned :)
@bhallaresearch.bsky.social
@gbadegesinlab.bsky.social @kidneyomicsamps.bsky.social
More to come soon on M1…. Stay tuned :)
@bhallaresearch.bsky.social
@gbadegesinlab.bsky.social @kidneyomicsamps.bsky.social
Prevalence of the M1 Modifier p.N264K in APOL1 Among Individuals With Kidney Disease Undergoing Commercial Genetic Testing in the United States
bit.ly/48PB2xk (FREE)
bit.ly/48PB2xk (FREE)
November 25, 2025 at 2:02 PM
Interesting read on the protective p.N264k (M1) #APOL1 variant and #kidneydisease and #FSGS.
More to come soon on M1…. Stay tuned :)
@bhallaresearch.bsky.social
@gbadegesinlab.bsky.social @kidneyomicsamps.bsky.social
More to come soon on M1…. Stay tuned :)
@bhallaresearch.bsky.social
@gbadegesinlab.bsky.social @kidneyomicsamps.bsky.social
Reposted by haysamrady
Just received my complimentary copy of Tropical Nephrology (2nd Ed.) 📘🌿
Recently discussed my chapter on kidney disease from herbal medicine with our fellows—2 days later we saw an AKI case linked to these products.
We must ask about herbal meds/supplements routinely. #AKI #CKD
Recently discussed my chapter on kidney disease from herbal medicine with our fellows—2 days later we saw an AKI case linked to these products.
We must ask about herbal meds/supplements routinely. #AKI #CKD
November 25, 2025 at 4:57 PM
Reposted by haysamrady
(1/2) The picture shows tissue submitted for routine immunofluorescence (fibrinogen stain is shown). Careful inspection confirms that this is an artery cross section which contains abnormal intraluminal tissue elements with numerous cleft-like spaces (see arrow).
#TeachingPoints #kidneypath #renal
#TeachingPoints #kidneypath #renal
November 25, 2025 at 5:21 PM
(1/2) The picture shows tissue submitted for routine immunofluorescence (fibrinogen stain is shown). Careful inspection confirms that this is an artery cross section which contains abnormal intraluminal tissue elements with numerous cleft-like spaces (see arrow).
#TeachingPoints #kidneypath #renal
#TeachingPoints #kidneypath #renal
Reposted by haysamrady
That was quick!
The US FDA approves Sibeprenlimab aka Voyxact for reducing proteinuria in IgA
www.fda.gov/drugs/novel-...
#NephSky
#TopNephrology
The US FDA approves Sibeprenlimab aka Voyxact for reducing proteinuria in IgA
www.fda.gov/drugs/novel-...
#NephSky
#TopNephrology
November 26, 2025 at 12:21 AM
That was quick!
The US FDA approves Sibeprenlimab aka Voyxact for reducing proteinuria in IgA
www.fda.gov/drugs/novel-...
#NephSky
#TopNephrology
The US FDA approves Sibeprenlimab aka Voyxact for reducing proteinuria in IgA
www.fda.gov/drugs/novel-...
#NephSky
#TopNephrology
Reposted by haysamrady
#NephJCshort on BICAR-ICU2 #Medsky #Nephsky
✍️ By @nephroseeker.medsky.social
🎭 Bicarbonate makes the picture look cleaner: better pH, more time. But beneath the smoother numbers, the patient hasn't changed. It's the same story, just told in softer colors
www.nephjc.com/news/2025/10...
✍️ By @nephroseeker.medsky.social
🎭 Bicarbonate makes the picture look cleaner: better pH, more time. But beneath the smoother numbers, the patient hasn't changed. It's the same story, just told in softer colors
www.nephjc.com/news/2025/10...
Dialysis deferred, logic recycled: BICAR ICU2 — NephJC
NephJC short on BICAR-ICU2
www.nephjc.com
November 25, 2025 at 12:19 AM
#NephJCshort on BICAR-ICU2 #Medsky #Nephsky
✍️ By @nephroseeker.medsky.social
🎭 Bicarbonate makes the picture look cleaner: better pH, more time. But beneath the smoother numbers, the patient hasn't changed. It's the same story, just told in softer colors
www.nephjc.com/news/2025/10...
✍️ By @nephroseeker.medsky.social
🎭 Bicarbonate makes the picture look cleaner: better pH, more time. But beneath the smoother numbers, the patient hasn't changed. It's the same story, just told in softer colors
www.nephjc.com/news/2025/10...
Reposted by haysamrady
Save the kidneys! Outpt AKI in cirrhosis
🤔Defined AKI with labs up to 1 yr apart
🤔12% developed AKI in 3 year
🤔🔼 with ascites, HCC, ETOH,
👍Need to avoid/modify precpt causes: diuretics, GI losses ie with lactulose, nephrotoxins
Review of AKi emcrit.org/ibcc/aki/#top
#gisky #medsky #imsky
🤔Defined AKI with labs up to 1 yr apart
🤔12% developed AKI in 3 year
🤔🔼 with ascites, HCC, ETOH,
👍Need to avoid/modify precpt causes: diuretics, GI losses ie with lactulose, nephrotoxins
Review of AKi emcrit.org/ibcc/aki/#top
#gisky #medsky #imsky
November 23, 2025 at 1:19 PM
Save the kidneys! Outpt AKI in cirrhosis
🤔Defined AKI with labs up to 1 yr apart
🤔12% developed AKI in 3 year
🤔🔼 with ascites, HCC, ETOH,
👍Need to avoid/modify precpt causes: diuretics, GI losses ie with lactulose, nephrotoxins
Review of AKi emcrit.org/ibcc/aki/#top
#gisky #medsky #imsky
🤔Defined AKI with labs up to 1 yr apart
🤔12% developed AKI in 3 year
🤔🔼 with ascites, HCC, ETOH,
👍Need to avoid/modify precpt causes: diuretics, GI losses ie with lactulose, nephrotoxins
Review of AKi emcrit.org/ibcc/aki/#top
#gisky #medsky #imsky
Reposted by haysamrady
Unfortunate but not rare IgAN presentation. Pt in their 30's, no PMHx, presented with HTN emergency, CKD, hematuria, proteinuria. Advanced IgAN with severe IFTA, focal active crescents (M1 E1 S1 T2 C1). Wish we could catch these cases earlier. #renalpath #pathsky #nephsky
November 23, 2025 at 3:50 PM
Unfortunate but not rare IgAN presentation. Pt in their 30's, no PMHx, presented with HTN emergency, CKD, hematuria, proteinuria. Advanced IgAN with severe IFTA, focal active crescents (M1 E1 S1 T2 C1). Wish we could catch these cases earlier. #renalpath #pathsky #nephsky