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simulabetateam.bsky.social
SimulaBetaTeam
@simulabetateam.bsky.social
110 followers 200 following 3 posts
Current news on #insulin-#glucose #homeostasis and the physiological simulation software #SimulaBeta

Bochum, Ulm, London, Singapore

https://simulabeta.sourceforge.io
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simulabetateam.bsky.social
Recently, computer simulations with #SimulaBeta played a key role in the development of the fasting-based disposition index SPINA-DI, a substantially improved method to assess the function of the insulin-glucose feedback loop and for early diagnosis of diabetes mellitus. 🩺 doi.org/10.1111/1753...
4 Plots showing the hyperbolic relation between SPINA-GBeta (a measure for beta cell function) and SPINA-GR (reconstructed insulin receptor gain as a measure for insulin sensitivity). (A) SPINA-DI remains constant as long as changes in insulin sensitivity (as measured by SPINA-GR) are balanced by adequate variations in beta cell function (SPINA-GBeta, circles 1, 2, and 3). (B) If dynamic compensation fails, either due to insufficient adaptation to insulin resistance (circle 4) or primary beta cell failure (circle 5), the disposition index breaks down and is markedly reduced. (C) Computer simulations with systematic variations of insulin receptor gain (GR) and secretory capacity of beta cells (GBeta) and resulting blood glucose concentration. (D) SPINA-GBeta plotted against SPINA-GR in the definition dataset. Results of persons with normal glucose homeostasis are near the hyperbola of normal SPINA-DI. The ability of dynamical beta cell compensation is partly lost in prediabetes.
January 3, 2024 at 10:26 PM
simulabetateam.bsky.social
#SimulaBeta 3.1.2 is available. This service release fixes several bugs and is the first version to be based on #CyberUnits Bricks 2.0.

simulabeta.sourceforge.io
doi.org/10.5281/zeno...
doi.org/10.5281/zeno...
Screenshot of SimulaBeta 3.1.2 on macOS Ventura 13.4.1
January 3, 2024 at 7:10 PM