Nice. For you or your patients?

What's really interesting is the difference in comments from PCUK (deeply disappointed, come as a blow, mass screening saves lives) vs CRUK (this is a good, balanced evidence-based decision). These are not technical differences in opinion; they're strategic marketing choices.

Yes, I'd agree with that. It's certainly true that the NHS isn't ready for any kind of early AD diagnosis or treatment more than pills, so it was an opportunity to advocate for developing this capacity, so that when fantasticamab comes along, the whole thing doesn't have to start from scratch.

But yes this balance also needs to be struck with DMDs too. We should be optimistic about the near future and encourage investment in dementia, but we shouldn't ever complain about NICE when they make clear evidence-based decisions about drug cost-utility. I don't think we generally did this though.

More so around targeting dementia awareness campaigns.
It's tricky because YOD has historically been underdiagnosed and this needs fixing, but we also need to be mindful not to scare every menopausal 52-year old with brain fog that they might have dementia. It needs tough conversations sometimes.

Really tricky, but as you say a lot of it is leadership and knowing what you don't know. Having proper in-house expertise and experience - people who know their field and can provide technical advice to senior managers, some of whom may know very little about the condition they're representing.

The thing is, I get why they do this. But the mindset is that of a barrister thinking only about their client, with scant regard for anything else. If they’re too good and effective at this then we end up with wasteful policies that cause a lot of collateral damage. Just for an influencing ‘win’.

I very much relate to this.

First time I’ve seen them play with real soul for quite a while. That’s what the young lads seem to bring. Great stuff and a proper Spurs match, whatever the result.

Always described as a 'long shot' but the payoff if successful would have been huge - enough to restore the company's fortunes and more. As you say, it would've been cheap in terms of overall development costs - just the cost of a RCT!
Even a tiny signal could have been followed up, but sadly not.

Witkoff sounds like he’s a time share salesman and he’s behind on his monthly sales targets. Incredible that this is how the most powerful nation on earth conducts itself in geopolitical negotiations.

Hopefully though this will help to quell some of the noise coming from diet gurus that Alzheimer’s disease can be slowed down or even reversed by drastic dietary changes, although I doubt it. 😩

Absolutely correct. Obesity and metabolic dysfunction are mid-life risk factors. GLP-1s are logically in the same bracket as statins for long-term pharmacological risk reduction, not last minute treatments.

You could see it on the players’ faces at 30 mins well before the first goal was even scored. Frustration, despondency, they knew they had no feasible route to a win. Hard to watch. Lovely goal from Richie though, rescued just a tiny bit of pride.

It’s a great skill for students to learn but so hard to make fair and meritocratic, as well avoiding dramas, workload imbalances and infighting. Excellent preparation for academia though.