Funny…I lamented the lack of adiabatic in a post today too!!

🙋‍♂️

yeah, got the warning in Davis but did not feel anything

Interesting! Thanks for sending...we'll check it out!

Awesome! The crixivan story is the subject of my final lecture in advanced organic synthesis every year!!

funny...that's me 3-6 times/year, albeit on much smaller scale! And with no direct links between my income and my publications! 😎

I have covered mine in bluesky graffiti for the last couple years and will probably leave it that way for a bit! 😎

did you actually delete your account? I'm holding out hope that EM sells or...ummm...otherwise becomes uninvolved...

Tried a few oxone conditions...ultimately after trying tons of experiments, including collaboraring with folks from here & TPFKAT (the platform formerly known as twitter), we've concluded it's just a recalcitrant substrate!!

possible, but has not so far been terribly productive...we replaced the ortho methoxy (i.e. the one ortho to the oxidation site) with several things before getting our best result when it was H

Interesting...we'll look into it!

...and I wanted to edit my first comment to add that we also see oxidation up to the naphthalene as another isolable product in some cases

in many cases we (and others to whom we have sent substrate) see very low mass recovery, so lots of bad things can happen!

several things...the isolable products include 3° carbon hydroxylation and quinone methide products, i.e. where the site we want to oxidize is becomes the methide carbon and the para OCH3 becomes a carbonyl.