Samuel A. Myers' lab
@samyers-lab.bsky.social
Laboratory for Immunochemical Circuits at the La Jolla Institute for Immunology. Dept. of Pharmacology and Moore's Cancer Center, UCSD. Global Autoimmune Institute Assistant Professor. samyerslab.org
cool
Tattoo ink can accumulate in the lymph nodes, where it can induce a prominent and long-term inflammatory response, according to a study in mice. Tattoo ink at injection sites can also modulate immune responses to vaccines in mice. In PNAS: https://ow.ly/meuU50XCZjN
December 6, 2025 at 2:33 AM
cool
Imagine training for years or even decades to critically analyze and interpret data and graphs and then just having some program summarize a paper based on whatever the authors have written. Crazy.
October 24, 2025 at 3:15 PM
Imagine training for years or even decades to critically analyze and interpret data and graphs and then just having some program summarize a paper based on whatever the authors have written. Crazy.
@seth-shipman.bsky.social does it again.
Reverse transcribed ssDNA derepresses translation of a retron antiviral protein https://www.biorxiv.org/content/10.1101/2025.10.22.683967v1
October 23, 2025 at 4:12 AM
@seth-shipman.bsky.social does it again.
Reposted by Samuel A. Myers' lab
LJI is recruiting!
The La Jolla Institute for Immunology (LJI, San Diego, California) invites applications for a tenure-track faculty position.
The La Jolla Institute for Immunology (LJI, San Diego, California) invites applications for a tenure-track faculty position.
October 20, 2025 at 3:14 PM
LJI is recruiting!
The La Jolla Institute for Immunology (LJI, San Diego, California) invites applications for a tenure-track faculty position.
The La Jolla Institute for Immunology (LJI, San Diego, California) invites applications for a tenure-track faculty position.
Reposted by Samuel A. Myers' lab
We’re hiring! KUMC's Dept. of Microbiol., Mol. Genet. & Immunol. seeks a new Asst. Professor in Immunology. Be part of a vibrant department and benefit from association with the NCI-designated KU Cancer Center. Come join us in Kansas City! Apply here: kumc.wd5.myworkdayjobs.com/en-US/kumc-j...
October 20, 2025 at 8:57 PM
We’re hiring! KUMC's Dept. of Microbiol., Mol. Genet. & Immunol. seeks a new Asst. Professor in Immunology. Be part of a vibrant department and benefit from association with the NCI-designated KU Cancer Center. Come join us in Kansas City! Apply here: kumc.wd5.myworkdayjobs.com/en-US/kumc-j...
Reposted by Samuel A. Myers' lab
In our latest vaccine immunology study we tested whether it is possible to simultaneously prime multiple classes of broadly neutralizing antibodies (bnAbs) against HIV using a combination of germline-targeting (GT) immunogens. www.science.org/doi/10.1126/...
@scienceimmuno.bsky.social @lji.org
@scienceimmuno.bsky.social @lji.org
Simultaneous induction of multiple classes of broadly neutralizing antibody precursors by combination germline-targeting immunization in nonhuman primates
Simultaneous immunization with three germline-targeting immunogens primes multiple bnAb lineages in NHPs, advancing multiepitope HIV vaccine strategies.
www.science.org
October 20, 2025 at 2:42 PM
In our latest vaccine immunology study we tested whether it is possible to simultaneously prime multiple classes of broadly neutralizing antibodies (bnAbs) against HIV using a combination of germline-targeting (GT) immunogens. www.science.org/doi/10.1126/...
@scienceimmuno.bsky.social @lji.org
@scienceimmuno.bsky.social @lji.org
Reposted by Samuel A. Myers' lab
Our new review paper about Pathway-Centric PTM Data Analysis is out this week in #Proteomics!
We cover databases, enrichment tools, software for pathway reconstruction, and full-fledged platforms that help to interpret high-throughput PTM datasets.
Check it out here: doi.org/10.1002/pmic...
We cover databases, enrichment tools, software for pathway reconstruction, and full-fledged platforms that help to interpret high-throughput PTM datasets.
Check it out here: doi.org/10.1002/pmic...
Computational Approaches for Pathway‐Centric Analysis of Protein Post‐Translational Modifications
Protein function is dynamically modulated by post-translational modifications (PTMs). Many different types of PTMs can nowadays be identified and quantified at a large scale using mass spectrometry. ...
doi.org
October 20, 2025 at 7:07 AM
Our new review paper about Pathway-Centric PTM Data Analysis is out this week in #Proteomics!
We cover databases, enrichment tools, software for pathway reconstruction, and full-fledged platforms that help to interpret high-throughput PTM datasets.
Check it out here: doi.org/10.1002/pmic...
We cover databases, enrichment tools, software for pathway reconstruction, and full-fledged platforms that help to interpret high-throughput PTM datasets.
Check it out here: doi.org/10.1002/pmic...
Reposted by Samuel A. Myers' lab
Job alert! Looking for a mass spectrometry expert to come join our team. Please share and let me know if you have any personal recommendations. #teammassspec www.linkedin.com/jobs/view/43...
Vertex Pharmaceuticals hiring Mass Spectrometry Sr. Research Scientist in Boston, MA | LinkedIn
Posted 12:01:53 AM. Job DescriptionGeneral Summary:We are seeking a Mass Spectrometrist to join the Chemical Biology…See this and similar jobs on LinkedIn.
www.linkedin.com
October 7, 2025 at 1:33 PM
Job alert! Looking for a mass spectrometry expert to come join our team. Please share and let me know if you have any personal recommendations. #teammassspec www.linkedin.com/jobs/view/43...
Reposted by Samuel A. Myers' lab
My lab @stanfordmedicine.bsky.social is recruiting! We are looking for a postdoc at the interface of quantitative proteomics and G protein-coupled receptor (GPCR) biology:
postdocs.stanford.edu/prospective/...
#TeamMassSpec #Proteomics #GPCR #Postdoc
postdocs.stanford.edu/prospective/...
#TeamMassSpec #Proteomics #GPCR #Postdoc
Open Postdoctoral position, faculty mentor Ruth Huttenhain | Office of Postdoctoral Affairs
postdocs.stanford.edu
October 2, 2025 at 6:27 PM
My lab @stanfordmedicine.bsky.social is recruiting! We are looking for a postdoc at the interface of quantitative proteomics and G protein-coupled receptor (GPCR) biology:
postdocs.stanford.edu/prospective/...
#TeamMassSpec #Proteomics #GPCR #Postdoc
postdocs.stanford.edu/prospective/...
#TeamMassSpec #Proteomics #GPCR #Postdoc
Reposted by Samuel A. Myers' lab
Excited to finally present the lab's latest work in defining candidate causal genetic variants that drive autoimmune diseases and their effects on primary human T cell expression and function! www.nature.com/articles/s41...
Genetic and epigenetic screens in primary human T cells link candidate causal autoimmune variants to T cell networks - Nature Genetics
Massively parallel reporter assay in primary human CD4+ T cells and bulk and single-cell CRISPR-interference screens identify candidate causal variants linked to autoimmune disease risk that modulate ...
www.nature.com
September 18, 2025 at 8:50 PM
Excited to finally present the lab's latest work in defining candidate causal genetic variants that drive autoimmune diseases and their effects on primary human T cell expression and function! www.nature.com/articles/s41...
Reposted by Samuel A. Myers' lab
Researchers in a recent #ScienceReview examine the influence that biological sex exerts on the immune system and immune-related diseases.
Learn more: https://scim.ag/4ln58Le
Learn more: https://scim.ag/4ln58Le
Sex differences in tissue-specific immunity and immunology
Biological sex exerts a substantial influence on the immune system and immune-related diseases. Males are more susceptible to the acute effects of viral disease and certain cancers, whereas females ex...
scim.ag
September 14, 2025 at 8:18 PM
Researchers in a recent #ScienceReview examine the influence that biological sex exerts on the immune system and immune-related diseases.
Learn more: https://scim.ag/4ln58Le
Learn more: https://scim.ag/4ln58Le
So cool.
Scientists modified a glue gun to #3Dprint bone grafts directly onto breaks during surgery. The device has so far been tested in rabbits, but has potential for future use in humans. spkl.io/63327AuO5W
@cp-device.bsky.social
#SKKU Jung Seung Lee & colleagues
@cp-device.bsky.social
#SKKU Jung Seung Lee & colleagues
September 9, 2025 at 9:35 PM
So cool.
Reposted by Samuel A. Myers' lab
In @elife.bsky.social: IL-27 limits HSPC differentiation during infection and protects from stem cell exhaustion doi.org/10.7554/eLif...
IL-27 limits HSPC differentiation during infection and protects from stem cell exhaustion
doi.org
September 1, 2025 at 10:59 PM
In @elife.bsky.social: IL-27 limits HSPC differentiation during infection and protects from stem cell exhaustion doi.org/10.7554/eLif...
Reposted by Samuel A. Myers' lab
🧪 And House appropriators say: no cuts to NIH budget!
House subcommittee version just came out (link below). Holds NIH flat at $48 billion.
To be clear: this is far from over. But a good sign that science still matters across both sides of aisle.
YOUR VOICE MATTERS!!
House subcommittee version just came out (link below). Holds NIH flat at $48 billion.
To be clear: this is far from over. But a good sign that science still matters across both sides of aisle.
YOUR VOICE MATTERS!!
September 1, 2025 at 10:37 PM
🧪 And House appropriators say: no cuts to NIH budget!
House subcommittee version just came out (link below). Holds NIH flat at $48 billion.
To be clear: this is far from over. But a good sign that science still matters across both sides of aisle.
YOUR VOICE MATTERS!!
House subcommittee version just came out (link below). Holds NIH flat at $48 billion.
To be clear: this is far from over. But a good sign that science still matters across both sides of aisle.
YOUR VOICE MATTERS!!
We make cell engineering look easy....
August 28, 2025 at 7:17 PM
We make cell engineering look easy....
Morgan gave such a fascinating talk at a @cshlaboratory.bsky.social meeting last year we had to invite him for an encore. Please join us @lji.org! via @mskcancercenter.bsky.social
August 27, 2025 at 10:59 PM
Morgan gave such a fascinating talk at a @cshlaboratory.bsky.social meeting last year we had to invite him for an encore. Please join us @lji.org! via @mskcancercenter.bsky.social
Reposted by Samuel A. Myers' lab
A generation of scholarship, put on hold or lost. share.google/5Pw7Akh79qec...
August 23, 2025 at 5:08 PM
A generation of scholarship, put on hold or lost. share.google/5Pw7Akh79qec...
Reposted by Samuel A. Myers' lab
A new paper reports direct ubiquitination of a small molecule BRD1732 in cells. BR31732 ubiquitination is E3 ligase-dependent and leads to inhibition of proteasomal degradation.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Highly specific intracellular ubiquitination of a small molecule - Nature Chemical Biology
Li et al. discovered that the cytotoxic synthetic small molecule BRD1732 is directly ubiquitinated in cells. Ubiquitination of BRD1732 is E3 ligase dependent and leads to inhibition of proteasomal deg...
www.nature.com
August 21, 2025 at 4:25 PM
A new paper reports direct ubiquitination of a small molecule BRD1732 in cells. BR31732 ubiquitination is E3 ligase-dependent and leads to inhibition of proteasomal degradation.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Celebrating Al Burlingame's 41 years of the @asbmb.bsky.social Molecular and Cellular Proteomics meeting which he started before "proteomics" was a term. Congrats Al!
August 20, 2025 at 9:29 PM
Celebrating Al Burlingame's 41 years of the @asbmb.bsky.social Molecular and Cellular Proteomics meeting which he started before "proteomics" was a term. Congrats Al!
Reposted by Samuel A. Myers' lab
Evidence for Functional Regulation of the KLHL3/WNK Pathway by O-GlcNAcylation
#glycotime #Glycobiology
#glycotime #Glycobiology
Evidence for Functional Regulation of the KLHL3/WNK Pathway by O-GlcNAcylation
Abstract. The 42-member Kelch-like (KLHL) protein family are adaptors for ubiquitin E3 ligase complexes, governing the stability of a wide range of substra
academic.oup.com
August 17, 2025 at 2:39 PM
Evidence for Functional Regulation of the KLHL3/WNK Pathway by O-GlcNAcylation
#glycotime #Glycobiology
#glycotime #Glycobiology
Reposted by Samuel A. Myers' lab
🍹Zhang, Ma et al. report that ROS-activated O-GlcNAc transferase promotes FOXK2 O-GlcNAcylation and nuclear translocation to upregulate SLC7A11 expression, thereby modulating #ferroptosis sensitivity, #tumor development and chemoradiotherapy efficacy.
👉https://rdcu.be/eAN1I
bit.ly/3JasCWN
👉https://rdcu.be/eAN1I
bit.ly/3JasCWN
A ROS-mediated oxidation-O-GlcNAcylation cascade governs ferroptosis - Nature Cell Biology
Zhang, Ma et al. report that ROS-activated O-GlcNAc transferase promotes FOXK2 O-GlcNAcylation and nuclear translocation to upregulate SLC7A11 expression, thereby modulating ferroptosis sensitivity, t...
bit.ly
August 14, 2025 at 7:55 PM
🍹Zhang, Ma et al. report that ROS-activated O-GlcNAc transferase promotes FOXK2 O-GlcNAcylation and nuclear translocation to upregulate SLC7A11 expression, thereby modulating #ferroptosis sensitivity, #tumor development and chemoradiotherapy efficacy.
👉https://rdcu.be/eAN1I
bit.ly/3JasCWN
👉https://rdcu.be/eAN1I
bit.ly/3JasCWN
Reposted by Samuel A. Myers' lab
Excited to share our latest work developing molecular glue degraders of ZBTB11, now out in @natchembio.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
ZBTB11 depletion targets metabolic vulnerabilities in KRAS inhibitor-resistant PDAC - Nature Chemical Biology
Depletion of a transcriptional factor ZBTB11 using molecular glue degraders can overcome oxidative-phosphorylation-mediated KRAS inhibitor resistance in pancreatic ductal adenocarcinoma with low acute...
www.nature.com
August 11, 2025 at 1:51 PM
Excited to share our latest work developing molecular glue degraders of ZBTB11, now out in @natchembio.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Samuel A. Myers' lab
Our lab at Yale @yalemedicine.bsky.social seeks #postdocs with in vivo expertise to pioneer research at the intersection of tissue remodeling & aging. Work with us to uncover immunological & vascular drivers of ovarian aging, applying single-cell, spatial omics, and ML! jobrxiv.org/job/yale-uni...
Postdoctoral Fellow, Hattie Chung Lab (Yale School of Medicine)
Post a job in 3min, or find thousands of job offers like this one at jobRxiv!
jobrxiv.org
August 8, 2025 at 6:06 PM
Our lab at Yale @yalemedicine.bsky.social seeks #postdocs with in vivo expertise to pioneer research at the intersection of tissue remodeling & aging. Work with us to uncover immunological & vascular drivers of ovarian aging, applying single-cell, spatial omics, and ML! jobrxiv.org/job/yale-uni...
What... on earth...am I looking at?!?
Marine biodiversity: Gone with the wind? Our dispatch out now in @currentbiology.bsky.social
New research shows that wind and currents act as invisible barriers, reshaping our view of ocean connectivity. 🌊🪼
authors.elsevier.com/a/1lYLj3QW8S...
@iramaegele.bsky.social @msarscentre.bsky.social
New research shows that wind and currents act as invisible barriers, reshaping our view of ocean connectivity. 🌊🪼
authors.elsevier.com/a/1lYLj3QW8S...
@iramaegele.bsky.social @msarscentre.bsky.social
August 5, 2025 at 7:26 AM
What... on earth...am I looking at?!?
you can unclench a little bit....
Senate committee endorses NIH budget increase, rebuking Trump administration’s proposed 40% cut www.statnews.com/2025/07/31/n...
Senate committee endorses NIH budget increase, rebuking Trump administration’s proposed 40% cut
Senators from both parties endorsed a $400 million increase to the budget of the National Institutes of Health on Thursday
www.statnews.com
July 31, 2025 at 10:45 PM
you can unclench a little bit....