Rikeish R Muralitharan MD, PhD
@rikeish.bsky.social
Research Fellow @FZMarques lab, @monashbiol Gut microbiome. Immune system. Diet. SCFAs. Hypertension. he/him
🚨Do you have high blood pressure (BP) but not on meds?
Join our clinical study exploring how fibre supplements may lower BP naturally.
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📍 @AlfredHealth VIC
🔬 Ages 18–75
📲 Apply now: [email protected]
#ClinicalTrials #BP
Join our clinical study exploring how fibre supplements may lower BP naturally.
✅ Free health checks
$ Compensation for your time
📍 @AlfredHealth VIC
🔬 Ages 18–75
📲 Apply now: [email protected]
#ClinicalTrials #BP
May 18, 2025 at 10:21 PM
🚨Do you have high blood pressure (BP) but not on meds?
Join our clinical study exploring how fibre supplements may lower BP naturally.
✅ Free health checks
$ Compensation for your time
📍 @AlfredHealth VIC
🔬 Ages 18–75
📲 Apply now: [email protected]
#ClinicalTrials #BP
Join our clinical study exploring how fibre supplements may lower BP naturally.
✅ Free health checks
$ Compensation for your time
📍 @AlfredHealth VIC
🔬 Ages 18–75
📲 Apply now: [email protected]
#ClinicalTrials #BP
May 18, 2025 at 10:20 PM
Great team effort including Malindi, Vaughan Macefield, Damian Keating, Daniela Carnevale, and @fzmarques.bsky.social.
May 18, 2025 at 10:19 PM
Great team effort including Malindi, Vaughan Macefield, Damian Keating, Daniela Carnevale, and @fzmarques.bsky.social.
Press release: www.monash.edu/news/article...
New link revealed between hypertension and the gut
Monash University researchers have revealed how the gut – and what we eat – regulates high blood pressure, opening the door to more specialised potential new drugs.
www.monash.edu
January 30, 2025 at 3:59 AM
Press release: www.monash.edu/news/article...
Grateful to my mentors @fzmarques.bsky.social Dr Joanne O'Donnell and Charles Mackay who helped guide this work and to all co-authors for the support and funding bodies NHMRC, Heart Foundation Australia, @monashbiol.bsky.social @monashuniversity.bsky.social
January 30, 2025 at 3:59 AM
Grateful to my mentors @fzmarques.bsky.social Dr Joanne O'Donnell and Charles Mackay who helped guide this work and to all co-authors for the support and funding bodies NHMRC, Heart Foundation Australia, @monashbiol.bsky.social @monashuniversity.bsky.social
In short, the answer is yes, there is a gene-environment interaction that increases risk for hypertension. My colleague Dr Leticia Tavares has done more work in this area doi.org/10.1101/2024...
Rare pathogenic variants in G-protein coupled receptor genes involved in gut-to-host communication are associated with cardiovascular disease risk
Background: Gut microbial metabolites called short-chain fatty acids (SCFA) confer protective effects against cardiovascular disease and high blood pressure. Proposed mechanisms include anti-inflammat...
doi.org
January 30, 2025 at 3:59 AM
In short, the answer is yes, there is a gene-environment interaction that increases risk for hypertension. My colleague Dr Leticia Tavares has done more work in this area doi.org/10.1101/2024...
Mechanistic studies were performed in an animal model, so we asked ourselves whether these receptors are relevant to human hypertension
January 30, 2025 at 3:59 AM
Mechanistic studies were performed in an animal model, so we asked ourselves whether these receptors are relevant to human hypertension
Immune cells and the inflammation are linked to hypertension but direct targeting of immune cells has not been particularly effective. Perhaps we could target these receptors to reduce immune activation instead?
January 30, 2025 at 3:59 AM
Immune cells and the inflammation are linked to hypertension but direct targeting of immune cells has not been particularly effective. Perhaps we could target these receptors to reduce immune activation instead?
We show that absence of these receptors leads to higher gut permeability (aka leaky gut) associated with higher inflammation in target organ such as the kidney. We also show that the absence of these receptors in immune cells was sufficient to worsen hypertension.
January 30, 2025 at 3:59 AM
We show that absence of these receptors leads to higher gut permeability (aka leaky gut) associated with higher inflammation in target organ such as the kidney. We also show that the absence of these receptors in immune cells was sufficient to worsen hypertension.
We and others have previously shown that SCFA supplementation can reduce BP but underlying mechanisms were unclear. Here we show that SCFA-receptors are protective in hypertension in the Ang II model.
January 30, 2025 at 3:59 AM
We and others have previously shown that SCFA supplementation can reduce BP but underlying mechanisms were unclear. Here we show that SCFA-receptors are protective in hypertension in the Ang II model.